Virulence Factors and Pathogenicity Mechanisms of <i>Acinetobacter baumannii</i> in Respiratory Infectious Diseases
<i>Acinetobacter baumannii</i> (<i>A. baumannii</i>) has become a notorious pathogen causing nosocomial and community-acquired infections, especially ventilator-associated pneumonia. This opportunistic pathogen is found to possess powerful genomic plasticity and numerous viru...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-12-01
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| Series: | Antibiotics |
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| Online Access: | https://www.mdpi.com/2079-6382/12/12/1749 |
| _version_ | 1827575805170941952 |
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| author | Yake Yao Qi Chen Hua Zhou |
| author_facet | Yake Yao Qi Chen Hua Zhou |
| author_sort | Yake Yao |
| collection | DOAJ |
| description | <i>Acinetobacter baumannii</i> (<i>A. baumannii</i>) has become a notorious pathogen causing nosocomial and community-acquired infections, especially ventilator-associated pneumonia. This opportunistic pathogen is found to possess powerful genomic plasticity and numerous virulence factors that facilitate its success in the infectious process. Although the interactions between <i>A. baumannii</i> and the pulmonary epitheliums have been extensively studied, a complete and specific description of its overall pathogenic process is lacking. In this review, we summarize the current knowledge of the antibiotic resistance and virulence factors of <i>A. baumannii</i>, specifically focusing on the pathogenic mechanisms of this detrimental pathogen in respiratory infectious diseases. An expansion of the knowledge regarding <i>A. baumannii</i> pathogenesis will contribute to the development of effective therapies based on immunopathology or intracellular signaling pathways to eliminate this harmful pathogen during infections. |
| first_indexed | 2024-03-08T21:02:11Z |
| format | Article |
| id | doaj.art-0279fb38d00d4b45bf560345c65e5be2 |
| institution | Directory Open Access Journal |
| issn | 2079-6382 |
| language | English |
| last_indexed | 2024-03-08T21:02:11Z |
| publishDate | 2023-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Antibiotics |
| spelling | doaj.art-0279fb38d00d4b45bf560345c65e5be22023-12-22T13:48:08ZengMDPI AGAntibiotics2079-63822023-12-011212174910.3390/antibiotics12121749Virulence Factors and Pathogenicity Mechanisms of <i>Acinetobacter baumannii</i> in Respiratory Infectious DiseasesYake Yao0Qi Chen1Hua Zhou2Department of Respiratory and Critical Care Medicine, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, ChinaDepartment of Respiratory and Critical Care Medicine, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, ChinaDepartment of Respiratory and Critical Care Medicine, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, China<i>Acinetobacter baumannii</i> (<i>A. baumannii</i>) has become a notorious pathogen causing nosocomial and community-acquired infections, especially ventilator-associated pneumonia. This opportunistic pathogen is found to possess powerful genomic plasticity and numerous virulence factors that facilitate its success in the infectious process. Although the interactions between <i>A. baumannii</i> and the pulmonary epitheliums have been extensively studied, a complete and specific description of its overall pathogenic process is lacking. In this review, we summarize the current knowledge of the antibiotic resistance and virulence factors of <i>A. baumannii</i>, specifically focusing on the pathogenic mechanisms of this detrimental pathogen in respiratory infectious diseases. An expansion of the knowledge regarding <i>A. baumannii</i> pathogenesis will contribute to the development of effective therapies based on immunopathology or intracellular signaling pathways to eliminate this harmful pathogen during infections.https://www.mdpi.com/2079-6382/12/12/1749<i>Acinetobacter baumannii</i>virulence factorsbacterial pathogenesisrespiratory infectious diseaseslung injuryhost–pathogen interaction |
| spellingShingle | Yake Yao Qi Chen Hua Zhou Virulence Factors and Pathogenicity Mechanisms of <i>Acinetobacter baumannii</i> in Respiratory Infectious Diseases Antibiotics <i>Acinetobacter baumannii</i> virulence factors bacterial pathogenesis respiratory infectious diseases lung injury host–pathogen interaction |
| title | Virulence Factors and Pathogenicity Mechanisms of <i>Acinetobacter baumannii</i> in Respiratory Infectious Diseases |
| title_full | Virulence Factors and Pathogenicity Mechanisms of <i>Acinetobacter baumannii</i> in Respiratory Infectious Diseases |
| title_fullStr | Virulence Factors and Pathogenicity Mechanisms of <i>Acinetobacter baumannii</i> in Respiratory Infectious Diseases |
| title_full_unstemmed | Virulence Factors and Pathogenicity Mechanisms of <i>Acinetobacter baumannii</i> in Respiratory Infectious Diseases |
| title_short | Virulence Factors and Pathogenicity Mechanisms of <i>Acinetobacter baumannii</i> in Respiratory Infectious Diseases |
| title_sort | virulence factors and pathogenicity mechanisms of i acinetobacter baumannii i in respiratory infectious diseases |
| topic | <i>Acinetobacter baumannii</i> virulence factors bacterial pathogenesis respiratory infectious diseases lung injury host–pathogen interaction |
| url | https://www.mdpi.com/2079-6382/12/12/1749 |
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