Induction of apoptosis by apocarotenoids in B16 melanoma cells through ROS-mediated mitochondrial-dependent pathway

Induction of apoptosis by apocarotenoids in B16 melanoma cells through ROS-mediated mitochondrial-dependent pathway

Bixin and norbixin are natural food colourants synthesised from Bixa orellana L seeds. This study explores the mechanism of apocarotenoids (bixin and norbixin) on the aggressive B16 murine melanoma as an anti-cancer agent. The apocarotenoids inhibited the cell viability of B16 melanoma in a time- an...

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Bibliographic Details
Main Authors: Amrita Anantharaman, Hridya Hemachandran, Sankari Mohan, Dhanoop Manikoth Ayyathan, Thirumal Kumar D, George Priya Doss C, Ramamoorthy Siva
Format: Article
Language:English
Published: Elsevier 2016-01-01
Series:Journal of Functional Foods
Subjects:
Food colourant
Bixin
Norbixin
Apoptosis
Cell cycle
B16 melanoma
Online Access:http://www.sciencedirect.com/science/article/pii/S1756464615005605

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