Threat of Dengue to Blood Safety in Dengue-Endemic Countries
Dengue, the most common arbovirus infection globally, is transmitted by mosquito vectors. Healthcare-related transmission, including transmission by blood products, has been documented, although the frequency of these occurrences is unknown. Dengue is endemic to Singapore, a city-state in Asia. Usin...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Centers for Disease Control and Prevention
2009-01-01
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| Series: | Emerging Infectious Diseases |
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| Online Access: | https://wwwnc.cdc.gov/eid/article/15/1/07-1097_article |
| _version_ | 1828965097101328384 |
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| author | Annelies Wilder-Smith Lin H. Chen Eduardo Massad Mary E. Wilson |
| author_facet | Annelies Wilder-Smith Lin H. Chen Eduardo Massad Mary E. Wilson |
| author_sort | Annelies Wilder-Smith |
| collection | DOAJ |
| description | Dengue, the most common arbovirus infection globally, is transmitted by mosquito vectors. Healthcare-related transmission, including transmission by blood products, has been documented, although the frequency of these occurrences is unknown. Dengue is endemic to Singapore, a city-state in Asia. Using mathematical modeling, we estimated the risk for dengue-infected blood transfusions in Singapore in 2005 to be 1.625–6/10,000 blood transfusions, assuming a ratio of asymptomatic to symptomatic infections of 2:1 to 10:1. However, the level of viremia required to cause clinical dengue cases is person-dependent and unknown. Further studies are needed to establish the magnitude of the threat that dengue poses to blood safety in countries where it is endemic. It will then be possible after this information is obtained to assess whether screening is feasible and to identify approaches that are most cost-effective on the basis of characteristics of local populations and seasonality of dengue. |
| first_indexed | 2024-12-14T11:03:56Z |
| format | Article |
| id | doaj.art-027c4417fd72449abf15918586178a31 |
| institution | Directory Open Access Journal |
| issn | 1080-6040 1080-6059 |
| language | English |
| last_indexed | 2024-12-14T11:03:56Z |
| publishDate | 2009-01-01 |
| publisher | Centers for Disease Control and Prevention |
| record_format | Article |
| series | Emerging Infectious Diseases |
| spelling | doaj.art-027c4417fd72449abf15918586178a312022-12-21T23:04:37ZengCenters for Disease Control and PreventionEmerging Infectious Diseases1080-60401080-60592009-01-0115181110.3201/eid1501.071097Threat of Dengue to Blood Safety in Dengue-Endemic CountriesAnnelies Wilder-SmithLin H. ChenEduardo MassadMary E. WilsonDengue, the most common arbovirus infection globally, is transmitted by mosquito vectors. Healthcare-related transmission, including transmission by blood products, has been documented, although the frequency of these occurrences is unknown. Dengue is endemic to Singapore, a city-state in Asia. Using mathematical modeling, we estimated the risk for dengue-infected blood transfusions in Singapore in 2005 to be 1.625–6/10,000 blood transfusions, assuming a ratio of asymptomatic to symptomatic infections of 2:1 to 10:1. However, the level of viremia required to cause clinical dengue cases is person-dependent and unknown. Further studies are needed to establish the magnitude of the threat that dengue poses to blood safety in countries where it is endemic. It will then be possible after this information is obtained to assess whether screening is feasible and to identify approaches that are most cost-effective on the basis of characteristics of local populations and seasonality of dengue.https://wwwnc.cdc.gov/eid/article/15/1/07-1097_articleDengueblood safetyblood transfusionsnon-vector transmissionnosocomial transmissionparenteral transmission |
| spellingShingle | Annelies Wilder-Smith Lin H. Chen Eduardo Massad Mary E. Wilson Threat of Dengue to Blood Safety in Dengue-Endemic Countries Emerging Infectious Diseases Dengue blood safety blood transfusions non-vector transmission nosocomial transmission parenteral transmission |
| title | Threat of Dengue to Blood Safety in Dengue-Endemic Countries |
| title_full | Threat of Dengue to Blood Safety in Dengue-Endemic Countries |
| title_fullStr | Threat of Dengue to Blood Safety in Dengue-Endemic Countries |
| title_full_unstemmed | Threat of Dengue to Blood Safety in Dengue-Endemic Countries |
| title_short | Threat of Dengue to Blood Safety in Dengue-Endemic Countries |
| title_sort | threat of dengue to blood safety in dengue endemic countries |
| topic | Dengue blood safety blood transfusions non-vector transmission nosocomial transmission parenteral transmission |
| url | https://wwwnc.cdc.gov/eid/article/15/1/07-1097_article |
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