Efficacy & safety of Desmopressin in the treatment of pediatric nocturnal enuresis
Back ground: primary nocturnal enuresis (PNE) is a socially distressing condition that can be troubling for children & their families. It affects 15-26% of five years olds. Several approaches are used to treat PNE including behavioral modification, alarms & drug therapy. Aim of the study: t...
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| Format: | Article |
| Language: | English |
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University of Baghdad/ Al-Kindy College of Medicine
2014-01-01
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| Series: | مجله كليه طب الكندي |
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| Online Access: | https://jkmc.uobaghdad.edu.iq/index.php/MEDICAL/article/view/503 |
| _version_ | 1798002127894740992 |
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| author | Ala’a Al-Deen |
| author_facet | Ala’a Al-Deen |
| author_sort | Ala’a Al-Deen |
| collection | DOAJ |
| description |
Back ground: primary nocturnal enuresis (PNE) is a socially distressing condition that can be troubling for children & their families. It affects 15-26% of five years olds. Several approaches are used to treat PNE including behavioral modification, alarms & drug therapy. Aim of the study: to determine the efficacy and safety of nasal desmopressin treatment in children with PNEPatients : fifty-four children with primary nocturnal enuresis with a mean age of ( 8.2) years ( range 6-15), underwent a 2 week observation period followed by entrance into a randomized controlled study, comparing desmopressin & placebo, lasting 4 weeks. The efficacy of the drug was measured in reduction of the number of wet nights per week. The enuretic status of the children was documented for 4 weeks after the treatment was stopped.Results: a significant reduction was found in the mean wet nights per week in the desmopressin group (p=0.001) as compared to placebo group (p = 0.83), from 4.3 wet nights during pretreatment to 0.6 & from 4.6 to 4.4 respectively, however this effect was not sustained after treatment was finished as only five children (18.5%) in the drug-treated group remained dry compared with one child (3.7%) in the placebo group. Side effects associated with the nasal adminstration of desmopressin were mild & infrequent.Conclusion: desmopressin has a clinically significant & safe effect on children with primary nocturnal enuresis
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| first_indexed | 2024-04-11T11:47:13Z |
| format | Article |
| id | doaj.art-027c5d5b51224ea88a5b1af9d370ae75 |
| institution | Directory Open Access Journal |
| issn | 1810-9543 2521-4365 |
| language | English |
| last_indexed | 2024-04-11T11:47:13Z |
| publishDate | 2014-01-01 |
| publisher | University of Baghdad/ Al-Kindy College of Medicine |
| record_format | Article |
| series | مجله كليه طب الكندي |
| spelling | doaj.art-027c5d5b51224ea88a5b1af9d370ae752022-12-22T04:25:30ZengUniversity of Baghdad/ Al-Kindy College of Medicineمجله كليه طب الكندي1810-95432521-43652014-01-01101Efficacy & safety of Desmopressin in the treatment of pediatric nocturnal enuresisAla’a Al-Deen0AL-mustansiriya university college of medicine Back ground: primary nocturnal enuresis (PNE) is a socially distressing condition that can be troubling for children & their families. It affects 15-26% of five years olds. Several approaches are used to treat PNE including behavioral modification, alarms & drug therapy. Aim of the study: to determine the efficacy and safety of nasal desmopressin treatment in children with PNEPatients : fifty-four children with primary nocturnal enuresis with a mean age of ( 8.2) years ( range 6-15), underwent a 2 week observation period followed by entrance into a randomized controlled study, comparing desmopressin & placebo, lasting 4 weeks. The efficacy of the drug was measured in reduction of the number of wet nights per week. The enuretic status of the children was documented for 4 weeks after the treatment was stopped.Results: a significant reduction was found in the mean wet nights per week in the desmopressin group (p=0.001) as compared to placebo group (p = 0.83), from 4.3 wet nights during pretreatment to 0.6 & from 4.6 to 4.4 respectively, however this effect was not sustained after treatment was finished as only five children (18.5%) in the drug-treated group remained dry compared with one child (3.7%) in the placebo group. Side effects associated with the nasal adminstration of desmopressin were mild & infrequent.Conclusion: desmopressin has a clinically significant & safe effect on children with primary nocturnal enuresis https://jkmc.uobaghdad.edu.iq/index.php/MEDICAL/article/view/503nocturnal enuresisDesmopressin |
| spellingShingle | Ala’a Al-Deen Efficacy & safety of Desmopressin in the treatment of pediatric nocturnal enuresis مجله كليه طب الكندي nocturnal enuresis Desmopressin |
| title | Efficacy & safety of Desmopressin in the treatment of pediatric nocturnal enuresis |
| title_full | Efficacy & safety of Desmopressin in the treatment of pediatric nocturnal enuresis |
| title_fullStr | Efficacy & safety of Desmopressin in the treatment of pediatric nocturnal enuresis |
| title_full_unstemmed | Efficacy & safety of Desmopressin in the treatment of pediatric nocturnal enuresis |
| title_short | Efficacy & safety of Desmopressin in the treatment of pediatric nocturnal enuresis |
| title_sort | efficacy safety of desmopressin in the treatment of pediatric nocturnal enuresis |
| topic | nocturnal enuresis Desmopressin |
| url | https://jkmc.uobaghdad.edu.iq/index.php/MEDICAL/article/view/503 |
| work_keys_str_mv | AT alaaaldeen efficacysafetyofdesmopressininthetreatmentofpediatricnocturnalenuresis |