Association of esophageal motility disorder symptoms with Chicago classification versions 3.0 and 4.0 using high-resolution esophageal manometry: A single-center experience from Saudi Arabia
Background: Esophageal motility disorders (EMDs) can significantly impact patients' quality of life. The Chicago Classification (CC) was developed as a robust framework to enable clinicians to better understand and classify the nature of motility disorders. Previous studies have primarily focus...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wolters Kluwer Medknow Publications
2024-01-01
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| Series: | The Saudi Journal of Gastroenterology |
| Subjects: | |
| Online Access: | http://www.saudijgastro.com/article.asp?issn=1319-3767;year=2024;volume=30;issue=2;spage=96;epage=102;aulast=Alzahrani |
| _version_ | 1797221600608649216 |
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| author | Mohammed A Alzahrani Mohammed A Alfahadi Meshref A Alshehri Abdulaziz H Alamri Eman A Almahjani Aishah M Alahmari Abdullah A Al-Shahrani Abdulaziz S Alshahrani Ibrahim M Almanjahi Abdullah M Alqarni |
| author_facet | Mohammed A Alzahrani Mohammed A Alfahadi Meshref A Alshehri Abdulaziz H Alamri Eman A Almahjani Aishah M Alahmari Abdullah A Al-Shahrani Abdulaziz S Alshahrani Ibrahim M Almanjahi Abdullah M Alqarni |
| author_sort | Mohammed A Alzahrani |
| collection | DOAJ |
| description | Background: Esophageal motility disorders (EMDs) can significantly impact patients' quality of life. The Chicago Classification (CC) was developed as a robust framework to enable clinicians to better understand and classify the nature of motility disorders. Previous studies have primarily focused on the CC version 3.0 (CCv3.0), and data regarding the correlation between symptoms and CC version 4.0 (CCv4.0) in the Saudi Arabian population are lacking. This study aimed to assess the correlation between symptoms and CCv3.0 and CCv4.0 using high-resolution esophageal manometry (HRM) in Saudi Arabia, to evaluate the diagnostic performance of both classifications.
Methods: A total of 182 patients presenting with esophageal symptoms were included in this study. HRM was performed to assess esophageal motility, and patients' reported symptoms were recorded. The association between HRM findings and symptomatic variables was analyzed using sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV).
Results: Variability was observed in the diagnostic performance of symptomatic variables for major EMDs. CCv4.0 demonstrated a higher sensitivity for dysphagia than CCv3.0; however, it exhibited lower sensitivity to atypical gastroesophageal reflux disease (GERD) symptoms. Noncardiac chest pain (NCCP) exhibited the highest specificity and PPV, whereas typical GERD symptoms showed lower specificity.
Conclusion: CCv4.0 demonstrated potential improvements in sensitivity for dysphagia, but lower sensitivity for atypical GERD symptoms, compared with CCv3.0. These insights provide guidance for clinicians in Saudi Arabia and contribute to understanding the diagnostic performance of CCv3.0 and CCv4.0. |
| first_indexed | 2024-04-24T13:08:01Z |
| format | Article |
| id | doaj.art-027c91945573422daf775ab2e629a13c |
| institution | Directory Open Access Journal |
| issn | 1319-3767 1998-4049 |
| language | English |
| last_indexed | 2024-04-24T13:08:01Z |
| publishDate | 2024-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | The Saudi Journal of Gastroenterology |
| spelling | doaj.art-027c91945573422daf775ab2e629a13c2024-04-05T05:29:04ZengWolters Kluwer Medknow PublicationsThe Saudi Journal of Gastroenterology1319-37671998-40492024-01-013029610210.4103/sjg.sjg_243_23Association of esophageal motility disorder symptoms with Chicago classification versions 3.0 and 4.0 using high-resolution esophageal manometry: A single-center experience from Saudi ArabiaMohammed A AlzahraniMohammed A AlfahadiMeshref A AlshehriAbdulaziz H AlamriEman A AlmahjaniAishah M AlahmariAbdullah A Al-ShahraniAbdulaziz S AlshahraniIbrahim M AlmanjahiAbdullah M AlqarniBackground: Esophageal motility disorders (EMDs) can significantly impact patients' quality of life. The Chicago Classification (CC) was developed as a robust framework to enable clinicians to better understand and classify the nature of motility disorders. Previous studies have primarily focused on the CC version 3.0 (CCv3.0), and data regarding the correlation between symptoms and CC version 4.0 (CCv4.0) in the Saudi Arabian population are lacking. This study aimed to assess the correlation between symptoms and CCv3.0 and CCv4.0 using high-resolution esophageal manometry (HRM) in Saudi Arabia, to evaluate the diagnostic performance of both classifications. Methods: A total of 182 patients presenting with esophageal symptoms were included in this study. HRM was performed to assess esophageal motility, and patients' reported symptoms were recorded. The association between HRM findings and symptomatic variables was analyzed using sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV). Results: Variability was observed in the diagnostic performance of symptomatic variables for major EMDs. CCv4.0 demonstrated a higher sensitivity for dysphagia than CCv3.0; however, it exhibited lower sensitivity to atypical gastroesophageal reflux disease (GERD) symptoms. Noncardiac chest pain (NCCP) exhibited the highest specificity and PPV, whereas typical GERD symptoms showed lower specificity. Conclusion: CCv4.0 demonstrated potential improvements in sensitivity for dysphagia, but lower sensitivity for atypical GERD symptoms, compared with CCv3.0. These insights provide guidance for clinicians in Saudi Arabia and contribute to understanding the diagnostic performance of CCv3.0 and CCv4.0.http://www.saudijgastro.com/article.asp?issn=1319-3767;year=2024;volume=30;issue=2;spage=96;epage=102;aulast=Alzahranichicago classificationdysphagiaesophageal symptomshigh-resolution esophageal manometry |
| spellingShingle | Mohammed A Alzahrani Mohammed A Alfahadi Meshref A Alshehri Abdulaziz H Alamri Eman A Almahjani Aishah M Alahmari Abdullah A Al-Shahrani Abdulaziz S Alshahrani Ibrahim M Almanjahi Abdullah M Alqarni Association of esophageal motility disorder symptoms with Chicago classification versions 3.0 and 4.0 using high-resolution esophageal manometry: A single-center experience from Saudi Arabia The Saudi Journal of Gastroenterology chicago classification dysphagia esophageal symptoms high-resolution esophageal manometry |
| title | Association of esophageal motility disorder symptoms with Chicago classification versions 3.0 and 4.0 using high-resolution esophageal manometry: A single-center experience from Saudi Arabia |
| title_full | Association of esophageal motility disorder symptoms with Chicago classification versions 3.0 and 4.0 using high-resolution esophageal manometry: A single-center experience from Saudi Arabia |
| title_fullStr | Association of esophageal motility disorder symptoms with Chicago classification versions 3.0 and 4.0 using high-resolution esophageal manometry: A single-center experience from Saudi Arabia |
| title_full_unstemmed | Association of esophageal motility disorder symptoms with Chicago classification versions 3.0 and 4.0 using high-resolution esophageal manometry: A single-center experience from Saudi Arabia |
| title_short | Association of esophageal motility disorder symptoms with Chicago classification versions 3.0 and 4.0 using high-resolution esophageal manometry: A single-center experience from Saudi Arabia |
| title_sort | association of esophageal motility disorder symptoms with chicago classification versions 3 0 and 4 0 using high resolution esophageal manometry a single center experience from saudi arabia |
| topic | chicago classification dysphagia esophageal symptoms high-resolution esophageal manometry |
| url | http://www.saudijgastro.com/article.asp?issn=1319-3767;year=2024;volume=30;issue=2;spage=96;epage=102;aulast=Alzahrani |
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