Microfabricated inserts for magic angle coil spinning (MACS) wireless NMR spectroscopy.
This article describes the development and testing of the first automatically microfabricated probes to be used in conjunction with the magic angle coil spinning (MACS) NMR technique. NMR spectroscopy is a versatile technique for a large range of applications, but its intrinsically low sensitivity p...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2012-01-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC3423418?pdf=render |
| _version_ | 1819025355430690816 |
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| author | Vlad Badilita Birgit Fassbender Kai Kratt Alan Wong Christian Bonhomme Dimitris Sakellariou Jan G Korvink Ulrike Wallrabe |
| author_facet | Vlad Badilita Birgit Fassbender Kai Kratt Alan Wong Christian Bonhomme Dimitris Sakellariou Jan G Korvink Ulrike Wallrabe |
| author_sort | Vlad Badilita |
| collection | DOAJ |
| description | This article describes the development and testing of the first automatically microfabricated probes to be used in conjunction with the magic angle coil spinning (MACS) NMR technique. NMR spectroscopy is a versatile technique for a large range of applications, but its intrinsically low sensitivity poses significant difficulties in analyzing mass- and volume-limited samples. The combination of microfabrication technology and MACS addresses several well-known NMR issues in a concerted manner for the first time: (i) reproducible wafer-scale fabrication of the first-in-kind on-chip LC microresonator for inductive coupling of the NMR signal and reliable exploitation of MACS capabilities; (ii) improving the sensitivity and the spectral resolution by simultaneous spinning the detection microcoil together with the sample at the "magic angle" of 54.74° with respect to the direction of the magnetic field (magic angle spinning - MAS), accompanied by the wireless signal transmission between the microcoil and the primary circuit of the NMR spectrometer; (iii) given the high spinning rates (tens of kHz) involved in the MAS methodology, the microfabricated inserts exhibit a clear kinematic advantage over their previously demonstrated counterparts due to the inherent capability to produce small radius cylindrical geometries, thus tremendously reducing the mechanical stress and tearing forces on the sample. In order to demonstrate the versatility of the microfabrication technology, we have designed MACS probes for various Larmor frequencies (194, 500 and 700 MHz) testing several samples such as water, Drosophila pupae, adamantane solid and LiCl at different magic angle spinning speeds. |
| first_indexed | 2024-12-21T05:09:22Z |
| format | Article |
| id | doaj.art-027fa72ae35c458eb913cd09f942602f |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-21T05:09:22Z |
| publishDate | 2012-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-027fa72ae35c458eb913cd09f942602f2022-12-21T19:15:06ZengPublic Library of Science (PLoS)PLoS ONE1932-62032012-01-0178e4284810.1371/journal.pone.0042848Microfabricated inserts for magic angle coil spinning (MACS) wireless NMR spectroscopy.Vlad BadilitaBirgit FassbenderKai KrattAlan WongChristian BonhommeDimitris SakellariouJan G KorvinkUlrike WallrabeThis article describes the development and testing of the first automatically microfabricated probes to be used in conjunction with the magic angle coil spinning (MACS) NMR technique. NMR spectroscopy is a versatile technique for a large range of applications, but its intrinsically low sensitivity poses significant difficulties in analyzing mass- and volume-limited samples. The combination of microfabrication technology and MACS addresses several well-known NMR issues in a concerted manner for the first time: (i) reproducible wafer-scale fabrication of the first-in-kind on-chip LC microresonator for inductive coupling of the NMR signal and reliable exploitation of MACS capabilities; (ii) improving the sensitivity and the spectral resolution by simultaneous spinning the detection microcoil together with the sample at the "magic angle" of 54.74° with respect to the direction of the magnetic field (magic angle spinning - MAS), accompanied by the wireless signal transmission between the microcoil and the primary circuit of the NMR spectrometer; (iii) given the high spinning rates (tens of kHz) involved in the MAS methodology, the microfabricated inserts exhibit a clear kinematic advantage over their previously demonstrated counterparts due to the inherent capability to produce small radius cylindrical geometries, thus tremendously reducing the mechanical stress and tearing forces on the sample. In order to demonstrate the versatility of the microfabrication technology, we have designed MACS probes for various Larmor frequencies (194, 500 and 700 MHz) testing several samples such as water, Drosophila pupae, adamantane solid and LiCl at different magic angle spinning speeds.http://europepmc.org/articles/PMC3423418?pdf=render |
| spellingShingle | Vlad Badilita Birgit Fassbender Kai Kratt Alan Wong Christian Bonhomme Dimitris Sakellariou Jan G Korvink Ulrike Wallrabe Microfabricated inserts for magic angle coil spinning (MACS) wireless NMR spectroscopy. PLoS ONE |
| title | Microfabricated inserts for magic angle coil spinning (MACS) wireless NMR spectroscopy. |
| title_full | Microfabricated inserts for magic angle coil spinning (MACS) wireless NMR spectroscopy. |
| title_fullStr | Microfabricated inserts for magic angle coil spinning (MACS) wireless NMR spectroscopy. |
| title_full_unstemmed | Microfabricated inserts for magic angle coil spinning (MACS) wireless NMR spectroscopy. |
| title_short | Microfabricated inserts for magic angle coil spinning (MACS) wireless NMR spectroscopy. |
| title_sort | microfabricated inserts for magic angle coil spinning macs wireless nmr spectroscopy |
| url | http://europepmc.org/articles/PMC3423418?pdf=render |
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