Onco-miR-24 regulates cell growth and apoptosis by targeting BCL2L11 in gastric cancer
ABSTRACT Gastric cancer is one of the most common malignancies worldwide; however, the molecular mechanism in tumorigenesis still needs exploration. BCL2L11 belongs to the BCL-2 family, and acts as a central regulator of the intrinsic apoptotic cascade and mediates cell apoptosis. Although miRNAs ha...
| Main Authors: | , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Oxford University Press
2016-01-01
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| Series: | Protein & Cell |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1007/s13238-015-0234-5 |
| _version_ | 1797725988997562368 |
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| author | Haiyang Zhang Jingjing Duan Yanjun Qu Ting Deng Rui Liu Le Zhang Ming Bai Jialu Li Tao Ning Shaohua Ge Xia Wang Zhenzhen Wang Qian Fan Hongli Li Guoguang Ying Dingzhi Huang Yi Ba |
| author_facet | Haiyang Zhang Jingjing Duan Yanjun Qu Ting Deng Rui Liu Le Zhang Ming Bai Jialu Li Tao Ning Shaohua Ge Xia Wang Zhenzhen Wang Qian Fan Hongli Li Guoguang Ying Dingzhi Huang Yi Ba |
| author_sort | Haiyang Zhang |
| collection | DOAJ |
| description | ABSTRACT Gastric cancer is one of the most common malignancies worldwide; however, the molecular mechanism in tumorigenesis still needs exploration. BCL2L11 belongs to the BCL-2 family, and acts as a central regulator of the intrinsic apoptotic cascade and mediates cell apoptosis. Although miRNAs have been reported to be involved in each stage of cancer development, the role of miR-24 in GC has not been reported yet. In the present study, miR-24 was found to be up-regulated while the expression of BCL2L11 was inhibited in tumor tissues of GC. Studies from both in vitro and in vivo shown that miR-24 regulates BCL2L11 expression by directly binding with 3′UTR of mRNA, thus promoting cell growth, migration while inhibiting cell apoptosis. Therefore, miR-24 is a novel onco-miRNA that can be potential drug targets for future clinical use. |
| first_indexed | 2024-03-12T10:39:14Z |
| format | Article |
| id | doaj.art-0280cb420bcc4b2fa20295ad0924f43e |
| institution | Directory Open Access Journal |
| issn | 1674-800X 1674-8018 |
| language | English |
| last_indexed | 2024-03-12T10:39:14Z |
| publishDate | 2016-01-01 |
| publisher | Oxford University Press |
| record_format | Article |
| series | Protein & Cell |
| spelling | doaj.art-0280cb420bcc4b2fa20295ad0924f43e2023-09-02T08:20:11ZengOxford University PressProtein & Cell1674-800X1674-80182016-01-017214115110.1007/s13238-015-0234-5Onco-miR-24 regulates cell growth and apoptosis by targeting BCL2L11 in gastric cancerHaiyang Zhang0Jingjing Duan1Yanjun Qu2Ting Deng3Rui Liu4Le Zhang5Ming Bai6Jialu Li7Tao Ning8Shaohua Ge9Xia Wang10Zhenzhen Wang11Qian Fan12Hongli Li13Guoguang Ying14Dingzhi Huang15Yi Ba16Tianjin Medical University Cancer Institute and Hospital, Key Laboratory of Cancer Prevention and Therapy, National Clinical Research Center for CancerTianjin Medical University Cancer Institute and Hospital, Key Laboratory of Cancer Prevention and Therapy, National Clinical Research Center for CancerTianjin Medical University Cancer Institute and Hospital, Key Laboratory of Cancer Prevention and Therapy, National Clinical Research Center for CancerTianjin Medical University Cancer Institute and Hospital, Key Laboratory of Cancer Prevention and Therapy, National Clinical Research Center for CancerTianjin Medical University Cancer Institute and Hospital, Key Laboratory of Cancer Prevention and Therapy, National Clinical Research Center for CancerTianjin Medical University Cancer Institute and Hospital, Key Laboratory of Cancer Prevention and Therapy, National Clinical Research Center for CancerTianjin Medical University Cancer Institute and Hospital, Key Laboratory of Cancer Prevention and Therapy, National Clinical Research Center for CancerDepartment of Gastroenterology, Tianjin First Center HospitalTianjin Medical University Cancer Institute and Hospital, Key Laboratory of Cancer Prevention and Therapy, National Clinical Research Center for CancerTianjin Medical University Cancer Institute and Hospital, Key Laboratory of Cancer Prevention and Therapy, National Clinical Research Center for CancerTianjin Medical University Cancer Institute and Hospital, Key Laboratory of Cancer Prevention and Therapy, National Clinical Research Center for CancerChangchun GeneScience Pharmaceuticals Co., LtdTianjin Medical University Cancer Institute and Hospital, Key Laboratory of Cancer Prevention and Therapy, National Clinical Research Center for CancerTianjin Medical University Cancer Institute and Hospital, Key Laboratory of Cancer Prevention and Therapy, National Clinical Research Center for CancerTianjin Medical University Cancer Institute and Hospital, Key Laboratory of Cancer Prevention and Therapy, National Clinical Research Center for CancerTianjin Medical University Cancer Institute and Hospital, Key Laboratory of Cancer Prevention and Therapy, National Clinical Research Center for CancerTianjin Medical University Cancer Institute and Hospital, Key Laboratory of Cancer Prevention and Therapy, National Clinical Research Center for CancerABSTRACT Gastric cancer is one of the most common malignancies worldwide; however, the molecular mechanism in tumorigenesis still needs exploration. BCL2L11 belongs to the BCL-2 family, and acts as a central regulator of the intrinsic apoptotic cascade and mediates cell apoptosis. Although miRNAs have been reported to be involved in each stage of cancer development, the role of miR-24 in GC has not been reported yet. In the present study, miR-24 was found to be up-regulated while the expression of BCL2L11 was inhibited in tumor tissues of GC. Studies from both in vitro and in vivo shown that miR-24 regulates BCL2L11 expression by directly binding with 3′UTR of mRNA, thus promoting cell growth, migration while inhibiting cell apoptosis. Therefore, miR-24 is a novel onco-miRNA that can be potential drug targets for future clinical use.http://link.springer.com/article/10.1007/s13238-015-0234-5gastric cancerBCL2L11miR-24tumorigenesiscell apoptosisproliferation |
| spellingShingle | Haiyang Zhang Jingjing Duan Yanjun Qu Ting Deng Rui Liu Le Zhang Ming Bai Jialu Li Tao Ning Shaohua Ge Xia Wang Zhenzhen Wang Qian Fan Hongli Li Guoguang Ying Dingzhi Huang Yi Ba Onco-miR-24 regulates cell growth and apoptosis by targeting BCL2L11 in gastric cancer Protein & Cell gastric cancer BCL2L11 miR-24 tumorigenesis cell apoptosis proliferation |
| title | Onco-miR-24 regulates cell growth and apoptosis by targeting BCL2L11 in gastric cancer |
| title_full | Onco-miR-24 regulates cell growth and apoptosis by targeting BCL2L11 in gastric cancer |
| title_fullStr | Onco-miR-24 regulates cell growth and apoptosis by targeting BCL2L11 in gastric cancer |
| title_full_unstemmed | Onco-miR-24 regulates cell growth and apoptosis by targeting BCL2L11 in gastric cancer |
| title_short | Onco-miR-24 regulates cell growth and apoptosis by targeting BCL2L11 in gastric cancer |
| title_sort | onco mir 24 regulates cell growth and apoptosis by targeting bcl2l11 in gastric cancer |
| topic | gastric cancer BCL2L11 miR-24 tumorigenesis cell apoptosis proliferation |
| url | http://link.springer.com/article/10.1007/s13238-015-0234-5 |
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