Leptospira interrogans biofilm formation in Rattus norvegicus (Norway rats) natural reservoirs.
Rattus norvegicus (Norway rat) is the main reservoir host of pathogenic Leptospira, the causative agent of leptospirosis, in urban environments. Pathogenic Leptospira forms biofilms in the environment, possibly contributing for bacterial survival and maintenance. Nonetheless, biofilms have not yet b...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2021-09-01
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| Series: | PLoS Neglected Tropical Diseases |
| Online Access: | https://doi.org/10.1371/journal.pntd.0009736 |
| _version_ | 1819094198356279296 |
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| author | Ana Amélia Nunes Santos Priscyla Dos Santos Ribeiro Geórgia Virgínia da França Fábio Neves Souza Eduardo Antônio Gonçalves Ramos Cláudio Pereira Figueira Mitermayer G Reis Federico Costa Paula Ristow |
| author_facet | Ana Amélia Nunes Santos Priscyla Dos Santos Ribeiro Geórgia Virgínia da França Fábio Neves Souza Eduardo Antônio Gonçalves Ramos Cláudio Pereira Figueira Mitermayer G Reis Federico Costa Paula Ristow |
| author_sort | Ana Amélia Nunes Santos |
| collection | DOAJ |
| description | Rattus norvegicus (Norway rat) is the main reservoir host of pathogenic Leptospira, the causative agent of leptospirosis, in urban environments. Pathogenic Leptospira forms biofilms in the environment, possibly contributing for bacterial survival and maintenance. Nonetheless, biofilms have not yet been studied in natural animal reservoirs presenting leptospiral renal carriage. Here, we described biofilm formation by pathogenic Leptospira inside the renal tubules of R. norvegicus naturally infected and captured in an urban slum endemic for leptospirosis. From the 65 rats carrying Leptospira in their kidneys, 24 (37%) presented biofilms inside the renal tubules. The intensity of leptospiral colonization in the renal tubules (OR: 1.00; 95% CI 1.05-1.1) and the type of occlusion pattern of the colonized renal tubules (OR: 3.46; 95% CI 1.20-9.98) were independently associated with the presence of Leptospira biofilm. Our data showed that Leptospira interrogans produce biofilms during renal chronic colonization in rat reservoirs, suggesting a possible role for leptospiral biofilms in the pathogenesis of leptospirosis and bacterial carriage in host reservoirs. |
| first_indexed | 2024-12-21T23:23:36Z |
| format | Article |
| id | doaj.art-0286175f26984e47ba859dca2543302f |
| institution | Directory Open Access Journal |
| issn | 1935-2727 1935-2735 |
| language | English |
| last_indexed | 2024-12-21T23:23:36Z |
| publishDate | 2021-09-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS Neglected Tropical Diseases |
| spelling | doaj.art-0286175f26984e47ba859dca2543302f2022-12-21T18:46:44ZengPublic Library of Science (PLoS)PLoS Neglected Tropical Diseases1935-27271935-27352021-09-01159e000973610.1371/journal.pntd.0009736Leptospira interrogans biofilm formation in Rattus norvegicus (Norway rats) natural reservoirs.Ana Amélia Nunes SantosPriscyla Dos Santos RibeiroGeórgia Virgínia da FrançaFábio Neves SouzaEduardo Antônio Gonçalves RamosCláudio Pereira FigueiraMitermayer G ReisFederico CostaPaula RistowRattus norvegicus (Norway rat) is the main reservoir host of pathogenic Leptospira, the causative agent of leptospirosis, in urban environments. Pathogenic Leptospira forms biofilms in the environment, possibly contributing for bacterial survival and maintenance. Nonetheless, biofilms have not yet been studied in natural animal reservoirs presenting leptospiral renal carriage. Here, we described biofilm formation by pathogenic Leptospira inside the renal tubules of R. norvegicus naturally infected and captured in an urban slum endemic for leptospirosis. From the 65 rats carrying Leptospira in their kidneys, 24 (37%) presented biofilms inside the renal tubules. The intensity of leptospiral colonization in the renal tubules (OR: 1.00; 95% CI 1.05-1.1) and the type of occlusion pattern of the colonized renal tubules (OR: 3.46; 95% CI 1.20-9.98) were independently associated with the presence of Leptospira biofilm. Our data showed that Leptospira interrogans produce biofilms during renal chronic colonization in rat reservoirs, suggesting a possible role for leptospiral biofilms in the pathogenesis of leptospirosis and bacterial carriage in host reservoirs.https://doi.org/10.1371/journal.pntd.0009736 |
| spellingShingle | Ana Amélia Nunes Santos Priscyla Dos Santos Ribeiro Geórgia Virgínia da França Fábio Neves Souza Eduardo Antônio Gonçalves Ramos Cláudio Pereira Figueira Mitermayer G Reis Federico Costa Paula Ristow Leptospira interrogans biofilm formation in Rattus norvegicus (Norway rats) natural reservoirs. PLoS Neglected Tropical Diseases |
| title | Leptospira interrogans biofilm formation in Rattus norvegicus (Norway rats) natural reservoirs. |
| title_full | Leptospira interrogans biofilm formation in Rattus norvegicus (Norway rats) natural reservoirs. |
| title_fullStr | Leptospira interrogans biofilm formation in Rattus norvegicus (Norway rats) natural reservoirs. |
| title_full_unstemmed | Leptospira interrogans biofilm formation in Rattus norvegicus (Norway rats) natural reservoirs. |
| title_short | Leptospira interrogans biofilm formation in Rattus norvegicus (Norway rats) natural reservoirs. |
| title_sort | leptospira interrogans biofilm formation in rattus norvegicus norway rats natural reservoirs |
| url | https://doi.org/10.1371/journal.pntd.0009736 |
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