HLA Class I Knockout Converts Allogeneic Primary NK Cells Into Suitable Effectors for “Off-the-Shelf” Immunotherapy

Cellular immunotherapy using chimeric antigen receptors (CARs) so far has almost exclusively used autologous peripheral blood-derived T cells as immune effector cells. However, harvesting sufficient numbers of T cells is often challenging in heavily pre-treated patients with malignancies and perturb...

詳細記述

書誌詳細
主要な著者: Keven Hoerster, Markus Uhrberg, Constanze Wiek, Peter A. Horn, Helmut Hanenberg, Stefan Heinrichs
フォーマット: 論文
言語:English
出版事項: Frontiers Media S.A. 2021-01-01
シリーズ:Frontiers in Immunology
主題:
オンライン・アクセス:https://www.frontiersin.org/articles/10.3389/fimmu.2020.586168/full