Blood pressure variability in Parkinson's Disease patients – Case control study

Introduction: The cardiovascular risk of Parkinson’s Disease (PD) patients is uncertain. Blood pressure variability (BPV) has been associated with cardiovascular and mortality outcomes. We aimed to evaluate blood pressure variability, as a marker of cardiovascular risk, in patients with PD and match...

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Main Authors: Mariana Alves, Daniel Caldeira, Joaquim J. Ferreira
Format: Article
Language:English
Published: Elsevier 2023-01-01
Series:Clinical Parkinsonism & Related Disorders
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S2590112523000099
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author Mariana Alves
Daniel Caldeira
Joaquim J. Ferreira
author_facet Mariana Alves
Daniel Caldeira
Joaquim J. Ferreira
author_sort Mariana Alves
collection DOAJ
description Introduction: The cardiovascular risk of Parkinson’s Disease (PD) patients is uncertain. Blood pressure variability (BPV) has been associated with cardiovascular and mortality outcomes. We aimed to evaluate blood pressure variability, as a marker of cardiovascular risk, in patients with PD and matched community controls. Methods: Cross-sectional case-control study was performed. All subjects included in the analysis were clinically evaluated and performed a 24 h ambulatory blood pressure monitoring. BPV was assessed using standard deviations (SDs) of the systolic blood pressure (SBP) and diastolic blood pressure (DBP) for each period – 24 h, daytime, and night-time. Results: The study included 204 participants, 102 in each group. Mean age 66 years old and 59% man. Most PD patients presented mild symptoms (mean Hoehn&Yahr 2.04). Daytime BPV was significantly higher in PD patients (SD SBP 14.1 mmHg vs 12.96 mmHg and SD DBP 9.39 mmHg vs 8.29 mmHg), but 24 h and night-time BPV were non-significantly increased. PD patients present non-significant higher night-time SBP (114 mmHg vs 110 mmHg) as well as higher frequency of non-dippers or reverse dippers BP profiles (51% vs 36%). Conclusion: Our exploratory study suggests that PD patients may present a higher blood pressure variability, which may translate in an increased cardiovascular risk. However, further studies are needed to confirm this hypothesis and causality.
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spelling doaj.art-0287db49a62949eda3c16f620d44b4052023-05-14T04:29:37ZengElsevierClinical Parkinsonism & Related Disorders2590-11252023-01-018100191Blood pressure variability in Parkinson's Disease patients – Case control studyMariana Alves0Daniel Caldeira1Joaquim J. Ferreira2Serviço de Medicina III, Hospital Pulido Valente, CHULN, Lisbon, Portugal; Laboratory of Clinical Pharmacology and Therapeutics, Faculdade de Medicina, Universidade de Lisboa, Portugal; Instituto de Medicina Molecular João Lobo Antunes, Faculdade de Medicina, Universidade de Lisboa, PortugalCentro Cardiovascular da Universidade de Lisboa – CCUL, CAML, Faculdade de Medicina, Universidade de Lisboa, Portugal; Serviço de Cardiologia, Hospital de Santa Maria, CHULN, Lisboa, PortugalLaboratory of Clinical Pharmacology and Therapeutics, Faculdade de Medicina, Universidade de Lisboa, Portugal; Instituto de Medicina Molecular João Lobo Antunes, Faculdade de Medicina, Universidade de Lisboa, Portugal; CNS – Campus Neurológico, Torres Vedras, Portugal; Corresponding author at: Laboratório de Farmacologia Clínica e Terapêutica, Faculdade de Medicina de Lisboa, Av. Prof. Egas Moniz, 1649-028 Lisboa, Portugal. Tel.: + 351 21 7802120.Introduction: The cardiovascular risk of Parkinson’s Disease (PD) patients is uncertain. Blood pressure variability (BPV) has been associated with cardiovascular and mortality outcomes. We aimed to evaluate blood pressure variability, as a marker of cardiovascular risk, in patients with PD and matched community controls. Methods: Cross-sectional case-control study was performed. All subjects included in the analysis were clinically evaluated and performed a 24 h ambulatory blood pressure monitoring. BPV was assessed using standard deviations (SDs) of the systolic blood pressure (SBP) and diastolic blood pressure (DBP) for each period – 24 h, daytime, and night-time. Results: The study included 204 participants, 102 in each group. Mean age 66 years old and 59% man. Most PD patients presented mild symptoms (mean Hoehn&Yahr 2.04). Daytime BPV was significantly higher in PD patients (SD SBP 14.1 mmHg vs 12.96 mmHg and SD DBP 9.39 mmHg vs 8.29 mmHg), but 24 h and night-time BPV were non-significantly increased. PD patients present non-significant higher night-time SBP (114 mmHg vs 110 mmHg) as well as higher frequency of non-dippers or reverse dippers BP profiles (51% vs 36%). Conclusion: Our exploratory study suggests that PD patients may present a higher blood pressure variability, which may translate in an increased cardiovascular risk. However, further studies are needed to confirm this hypothesis and causality.http://www.sciencedirect.com/science/article/pii/S2590112523000099Parkinson’s diseaseBlood pressure variabilityCardiovascular risk
spellingShingle Mariana Alves
Daniel Caldeira
Joaquim J. Ferreira
Blood pressure variability in Parkinson's Disease patients – Case control study
Clinical Parkinsonism & Related Disorders
Parkinson’s disease
Blood pressure variability
Cardiovascular risk
title Blood pressure variability in Parkinson's Disease patients – Case control study
title_full Blood pressure variability in Parkinson's Disease patients – Case control study
title_fullStr Blood pressure variability in Parkinson's Disease patients – Case control study
title_full_unstemmed Blood pressure variability in Parkinson's Disease patients – Case control study
title_short Blood pressure variability in Parkinson's Disease patients – Case control study
title_sort blood pressure variability in parkinson s disease patients case control study
topic Parkinson’s disease
Blood pressure variability
Cardiovascular risk
url http://www.sciencedirect.com/science/article/pii/S2590112523000099
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