MORPHOLOGICAL SPECTRUM OF ENDOMETRIAL BIOPSIES IN INFERTILE WOMAN
Background: Infertility is a global problem and as a last resort in the investigative protocol endometrial biopsy is performed to find a clue to the cause behind it. The objective of the study was to evaluate the morphological spectrum of endometrial biopsies in infertile women. Material & Me...
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| Format: | Article |
| Language: | English |
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Gomal Medical College, D.I.Khan, Pakistan
2017-01-01
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| Series: | Gomal Journal of Medical Sciences |
| Subjects: | |
| Online Access: | http://gjms.com.pk/ojs24/index.php/gjms/article/view/1385 |
| _version_ | 1818282073474990080 |
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| author | Sabeen Nasir Muhammad Mumtaz Khan Sajjad Ahmad Sara Ziaullah Sadaf Alam |
| author_facet | Sabeen Nasir Muhammad Mumtaz Khan Sajjad Ahmad Sara Ziaullah Sadaf Alam |
| author_sort | Sabeen Nasir |
| collection | DOAJ |
| description | Background: Infertility is a global problem and as a last resort in the investigative protocol endometrial biopsy is performed to find a clue to the cause behind it. The objective of the study was to evaluate the morphological spectrum of endometrial biopsies in infertile women.
Material & Methods: This cross-sectional study was conducted in Department of Pathology, Peshawar Medical College Peshawar from 21-04-2013 to 10-08-2013. Out of 168 infertile patients 8 were excluded due to insufficient representative material. The sample size was 160 infertile women of reproductive age group selected through consecutive sampling technique. In eight cases endometrial biopsy could not be assessed so these cases were excluded. Demographic variable was; age in years. Type of infertility, duration of infertility, morpholigical dating & presence of endometial carcinoma were the research variables. Descriptive statistics were calculated from data using SPSS version 18.
Results: Out of 160, 102(63.75%) were primary & 58(36.25) were secondary infertile women. Mean age of the sample was 26.70+4.90 in primary & 30.55+4.79 in secondary infertile women. Mean duration of infertility was 7.06+0.5 in primary & 7.27+0.5 in secondary infertile women. Morphological changes in endometrium of infertile women included; secretory phase in 102(63.75%), disordered proliferative endometrium in 28(17.5%), irregular maturation endometrium in 11(6.8), proliferative endometrium in 8(5%) complex hyperplasia in 6(3.7%), simple hyperplasia in 3(1.8%) & discordance between glands & stroma in 2(1.2%) cases. No malignant lesion was seen in our study population.
Conclusion: On premenstrual endometrial biopsy, secretory phase was the most common finding. No malignancy was reported. |
| first_indexed | 2024-12-13T00:15:13Z |
| format | Article |
| id | doaj.art-02898574fbd0473db9040fb4fa00adfb |
| institution | Directory Open Access Journal |
| issn | 1819-7973 1997-2067 |
| language | English |
| last_indexed | 2024-12-13T00:15:13Z |
| publishDate | 2017-01-01 |
| publisher | Gomal Medical College, D.I.Khan, Pakistan |
| record_format | Article |
| series | Gomal Journal of Medical Sciences |
| spelling | doaj.art-02898574fbd0473db9040fb4fa00adfb2022-12-22T00:05:49ZengGomal Medical College, D.I.Khan, PakistanGomal Journal of Medical Sciences1819-79731997-20672017-01-01143892MORPHOLOGICAL SPECTRUM OF ENDOMETRIAL BIOPSIES IN INFERTILE WOMANSabeen Nasir0Muhammad Mumtaz Khan1Sajjad Ahmad2Sara Ziaullah3Sadaf Alam4Pehawar Medical College, Riphah International University, IslamabadPehawar Medical College, Riphah International University, IslamabadPehawar Medical College, Riphah International University, IslamabadPehawar Medical College, Riphah International University, IslamabadPehawar Medical College, Riphah International University, IslamabadBackground: Infertility is a global problem and as a last resort in the investigative protocol endometrial biopsy is performed to find a clue to the cause behind it. The objective of the study was to evaluate the morphological spectrum of endometrial biopsies in infertile women. Material & Methods: This cross-sectional study was conducted in Department of Pathology, Peshawar Medical College Peshawar from 21-04-2013 to 10-08-2013. Out of 168 infertile patients 8 were excluded due to insufficient representative material. The sample size was 160 infertile women of reproductive age group selected through consecutive sampling technique. In eight cases endometrial biopsy could not be assessed so these cases were excluded. Demographic variable was; age in years. Type of infertility, duration of infertility, morpholigical dating & presence of endometial carcinoma were the research variables. Descriptive statistics were calculated from data using SPSS version 18. Results: Out of 160, 102(63.75%) were primary & 58(36.25) were secondary infertile women. Mean age of the sample was 26.70+4.90 in primary & 30.55+4.79 in secondary infertile women. Mean duration of infertility was 7.06+0.5 in primary & 7.27+0.5 in secondary infertile women. Morphological changes in endometrium of infertile women included; secretory phase in 102(63.75%), disordered proliferative endometrium in 28(17.5%), irregular maturation endometrium in 11(6.8), proliferative endometrium in 8(5%) complex hyperplasia in 6(3.7%), simple hyperplasia in 3(1.8%) & discordance between glands & stroma in 2(1.2%) cases. No malignant lesion was seen in our study population. Conclusion: On premenstrual endometrial biopsy, secretory phase was the most common finding. No malignancy was reported.http://gjms.com.pk/ojs24/index.php/gjms/article/view/1385infertility, endometrial biopsy, menstrual disturbances. |
| spellingShingle | Sabeen Nasir Muhammad Mumtaz Khan Sajjad Ahmad Sara Ziaullah Sadaf Alam MORPHOLOGICAL SPECTRUM OF ENDOMETRIAL BIOPSIES IN INFERTILE WOMAN Gomal Journal of Medical Sciences infertility, endometrial biopsy, menstrual disturbances. |
| title | MORPHOLOGICAL SPECTRUM OF ENDOMETRIAL BIOPSIES IN INFERTILE WOMAN |
| title_full | MORPHOLOGICAL SPECTRUM OF ENDOMETRIAL BIOPSIES IN INFERTILE WOMAN |
| title_fullStr | MORPHOLOGICAL SPECTRUM OF ENDOMETRIAL BIOPSIES IN INFERTILE WOMAN |
| title_full_unstemmed | MORPHOLOGICAL SPECTRUM OF ENDOMETRIAL BIOPSIES IN INFERTILE WOMAN |
| title_short | MORPHOLOGICAL SPECTRUM OF ENDOMETRIAL BIOPSIES IN INFERTILE WOMAN |
| title_sort | morphological spectrum of endometrial biopsies in infertile woman |
| topic | infertility, endometrial biopsy, menstrual disturbances. |
| url | http://gjms.com.pk/ojs24/index.php/gjms/article/view/1385 |
| work_keys_str_mv | AT sabeennasir morphologicalspectrumofendometrialbiopsiesininfertilewoman AT muhammadmumtazkhan morphologicalspectrumofendometrialbiopsiesininfertilewoman AT sajjadahmad morphologicalspectrumofendometrialbiopsiesininfertilewoman AT saraziaullah morphologicalspectrumofendometrialbiopsiesininfertilewoman AT sadafalam morphologicalspectrumofendometrialbiopsiesininfertilewoman |