Development of an Electrochemical Immunosensor for Detection of Cardiac Troponin I at the Point-of-Care
Cardiac troponin I (cTnI) plays an important role in the assessment of various cardiac diseases. However, accurate detection of cTnI at the point-of-care (POC) remains unfeasible. In this study, we report the development of an electrochemical immunosensor designed for rapid and accurate cTnI detecti...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-06-01
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| Series: | Biosensors |
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| Online Access: | https://www.mdpi.com/2079-6374/11/7/210 |
| _version_ | 1827601246477877248 |
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| author | Tsung-Han Lee Lung-Chieh Chen Erick Wang Chin-Cheng Wang Yan-Ren Lin Wen-Liang Chen |
| author_facet | Tsung-Han Lee Lung-Chieh Chen Erick Wang Chin-Cheng Wang Yan-Ren Lin Wen-Liang Chen |
| author_sort | Tsung-Han Lee |
| collection | DOAJ |
| description | Cardiac troponin I (cTnI) plays an important role in the assessment of various cardiac diseases. However, accurate detection of cTnI at the point-of-care (POC) remains unfeasible. In this study, we report the development of an electrochemical immunosensor designed for rapid and accurate cTnI detection in pre-hospital settings. Rapid cTnI analysis of whole blood samples was then performed. cTnI measurements were highly correlated with the results of the standard clinical laboratory method for cTnI detection. The results of this study suggest that the proposed POC immunosensor can deliver fast and accurate cTnI analysis in pre-hospital settings to achieve rapid diagnosis and guide patient management. |
| first_indexed | 2024-03-09T04:51:33Z |
| format | Article |
| id | doaj.art-02898c9e1d25418197e064fadca5178f |
| institution | Directory Open Access Journal |
| issn | 2079-6374 |
| language | English |
| last_indexed | 2024-03-09T04:51:33Z |
| publishDate | 2021-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biosensors |
| spelling | doaj.art-02898c9e1d25418197e064fadca5178f2023-12-03T13:09:51ZengMDPI AGBiosensors2079-63742021-06-0111721010.3390/bios11070210Development of an Electrochemical Immunosensor for Detection of Cardiac Troponin I at the Point-of-CareTsung-Han Lee0Lung-Chieh Chen1Erick Wang2Chin-Cheng Wang3Yan-Ren Lin4Wen-Liang Chen5Department of Emergency and Critical Care Medicine, Changhua Christian Hospital, Changhua 500, TaiwanDepartment of Biological Science and Technology, National Yang Ming Chiao Tung University, Hsinchu 300, TaiwanDepartment of Biological Science and Technology, National Yang Ming Chiao Tung University, Hsinchu 300, TaiwanDepartment of Biological Science and Technology, National Yang Ming Chiao Tung University, Hsinchu 300, TaiwanDepartment of Emergency and Critical Care Medicine, Changhua Christian Hospital, Changhua 500, TaiwanDepartment of Biological Science and Technology, National Yang Ming Chiao Tung University, Hsinchu 300, TaiwanCardiac troponin I (cTnI) plays an important role in the assessment of various cardiac diseases. However, accurate detection of cTnI at the point-of-care (POC) remains unfeasible. In this study, we report the development of an electrochemical immunosensor designed for rapid and accurate cTnI detection in pre-hospital settings. Rapid cTnI analysis of whole blood samples was then performed. cTnI measurements were highly correlated with the results of the standard clinical laboratory method for cTnI detection. The results of this study suggest that the proposed POC immunosensor can deliver fast and accurate cTnI analysis in pre-hospital settings to achieve rapid diagnosis and guide patient management.https://www.mdpi.com/2079-6374/11/7/210cardiac troponin Iimmunosensorpoint-of-care |
| spellingShingle | Tsung-Han Lee Lung-Chieh Chen Erick Wang Chin-Cheng Wang Yan-Ren Lin Wen-Liang Chen Development of an Electrochemical Immunosensor for Detection of Cardiac Troponin I at the Point-of-Care Biosensors cardiac troponin I immunosensor point-of-care |
| title | Development of an Electrochemical Immunosensor for Detection of Cardiac Troponin I at the Point-of-Care |
| title_full | Development of an Electrochemical Immunosensor for Detection of Cardiac Troponin I at the Point-of-Care |
| title_fullStr | Development of an Electrochemical Immunosensor for Detection of Cardiac Troponin I at the Point-of-Care |
| title_full_unstemmed | Development of an Electrochemical Immunosensor for Detection of Cardiac Troponin I at the Point-of-Care |
| title_short | Development of an Electrochemical Immunosensor for Detection of Cardiac Troponin I at the Point-of-Care |
| title_sort | development of an electrochemical immunosensor for detection of cardiac troponin i at the point of care |
| topic | cardiac troponin I immunosensor point-of-care |
| url | https://www.mdpi.com/2079-6374/11/7/210 |
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