Hemodynamic Forces Induce the Release of Nitric Oxide from Aortic Endothelium: Combined Effect of Shear Stress and Pressure
Introduction : Fluid shear stress (pulsatile and laminar) and pressure comprise of the two in vivo physical forces to which vascular endothelium is constantly exposed. Besides, vasodilator and autacoids, nitric oxide is the main endothelium derived relaxing factor (EDRF) released in response to alte...
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| Format: | Article |
| Language: | English |
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Sonali Sharma on behalf of Rajasthan University of Health Sciences
2023-09-01
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| Series: | RUHS Journal of Health Sciences |
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| Online Access: | https://ruhsjhs.in/articleDetails.php?artid=TVRrNA== |
| _version_ | 1827808247646519296 |
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| author | Husain S Yawer, Sadik R Panwar, Nidhi Priya , Ali S, Alok R Ray |
| author_facet | Husain S Yawer, Sadik R Panwar, Nidhi Priya , Ali S, Alok R Ray |
| author_sort | Husain S Yawer, Sadik R Panwar, Nidhi Priya , Ali S, Alok R Ray |
| collection | DOAJ |
| description | Introduction : Fluid shear stress (pulsatile and laminar) and pressure comprise of the two in vivo physical forces to which vascular endothelium is constantly exposed. Besides, vasodilator and autacoids, nitric oxide is the main endothelium derived relaxing factor (EDRF) released in response to alterations in blood pressure and shear stress, which constitute hemodynamic stress.The aim of the present study was to study the effect of pulsatile/laminar shear stress on endothelial nitric oxide production . Methodology: A perfusion system was used to study the effect of shear stress on endothelialnitic oxide production. It was designed as a close continuous flow loop in which the pressure was superimposed with flow through a pressure head with adjustable height. Results: At hydrostatic pressure of 70 cm water (normotensive condition) and at 150 cm water (hypertensive condition), an increase in nitric oxide concentration was observed. The increase was 10 fold higher at 150 cm with respect to static values than the increase observed at 70 cm ofwater. Conclusion: Laminar shear stress and pressure induce the release of endothelial nitric oxide, which may aid to understand the role of wall shear stress during arterial resistance in hypertension. |
| first_indexed | 2024-03-11T22:24:31Z |
| format | Article |
| id | doaj.art-028af44a53b34ca79e799a9df824cd41 |
| institution | Directory Open Access Journal |
| issn | 2456-8309 2582-3590 |
| language | English |
| last_indexed | 2024-03-11T22:24:31Z |
| publishDate | 2023-09-01 |
| publisher | Sonali Sharma on behalf of Rajasthan University of Health Sciences |
| record_format | Article |
| series | RUHS Journal of Health Sciences |
| spelling | doaj.art-028af44a53b34ca79e799a9df824cd412023-09-24T07:23:56ZengSonali Sharma on behalf of Rajasthan University of Health SciencesRUHS Journal of Health Sciences2456-83092582-35902023-09-01http://dx.doi.org/10.37821/ruhsjhs.3.1.2018.17-23Hemodynamic Forces Induce the Release of Nitric Oxide from Aortic Endothelium: Combined Effect of Shear Stress and PressureHusain S Yawer, Sadik R Panwar, Nidhi Priya , Ali S, Alok R Ray0Department of Dental Materials, RUHS College of Dental Sciences, Jaipur, Rajasthan; Consultant, Interventional Cardiology, Beckley ARH Hospital, Beckley, West Virginia, USA; Assistant Professor. Department of Pathology, RUHS College of Medical Sciences, Jaipur, Rajasthan, Professor and Head, Department of Biochemistry, Jamia Hamdard University, New Delhi, Professor, Centre for Biomedical Engineering, Indian Institute of Technology, New Delhi, IndiaIntroduction : Fluid shear stress (pulsatile and laminar) and pressure comprise of the two in vivo physical forces to which vascular endothelium is constantly exposed. Besides, vasodilator and autacoids, nitric oxide is the main endothelium derived relaxing factor (EDRF) released in response to alterations in blood pressure and shear stress, which constitute hemodynamic stress.The aim of the present study was to study the effect of pulsatile/laminar shear stress on endothelial nitric oxide production . Methodology: A perfusion system was used to study the effect of shear stress on endothelialnitic oxide production. It was designed as a close continuous flow loop in which the pressure was superimposed with flow through a pressure head with adjustable height. Results: At hydrostatic pressure of 70 cm water (normotensive condition) and at 150 cm water (hypertensive condition), an increase in nitric oxide concentration was observed. The increase was 10 fold higher at 150 cm with respect to static values than the increase observed at 70 cm ofwater. Conclusion: Laminar shear stress and pressure induce the release of endothelial nitric oxide, which may aid to understand the role of wall shear stress during arterial resistance in hypertension.https://ruhsjhs.in/articleDetails.php?artid=TVRrNA==Not available |
| spellingShingle | Husain S Yawer, Sadik R Panwar, Nidhi Priya , Ali S, Alok R Ray Hemodynamic Forces Induce the Release of Nitric Oxide from Aortic Endothelium: Combined Effect of Shear Stress and Pressure RUHS Journal of Health Sciences Not available |
| title | Hemodynamic Forces Induce the Release of Nitric Oxide from Aortic Endothelium: Combined Effect of Shear Stress and Pressure |
| title_full | Hemodynamic Forces Induce the Release of Nitric Oxide from Aortic Endothelium: Combined Effect of Shear Stress and Pressure |
| title_fullStr | Hemodynamic Forces Induce the Release of Nitric Oxide from Aortic Endothelium: Combined Effect of Shear Stress and Pressure |
| title_full_unstemmed | Hemodynamic Forces Induce the Release of Nitric Oxide from Aortic Endothelium: Combined Effect of Shear Stress and Pressure |
| title_short | Hemodynamic Forces Induce the Release of Nitric Oxide from Aortic Endothelium: Combined Effect of Shear Stress and Pressure |
| title_sort | hemodynamic forces induce the release of nitric oxide from aortic endothelium combined effect of shear stress and pressure |
| topic | Not available |
| url | https://ruhsjhs.in/articleDetails.php?artid=TVRrNA== |
| work_keys_str_mv | AT husainsyawersadikrpanwarnidhipriyaalisalokrray hemodynamicforcesinducethereleaseofnitricoxidefromaorticendotheliumcombinedeffectofshearstressandpressure |