Type M Resistance to Macrolides Is Due to a Two-Gene Efflux Transport System of the ATP-Binding Cassette (ABC) Superfamily

Type M Resistance to Macrolides Is Due to a Two-Gene Efflux Transport System of the ATP-Binding Cassette (ABC) Superfamily

The mef(A) gene was originally identified as the resistance determinant responsible for type M resistance to macrolides, a phenotype frequently found in clinical isolates of Streptococcus pneumoniae and Streptococcus pyogenes. MefA was defined as a secondary transporter of the major facilitator supe...

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Bibliographic Details
Main Authors: Francesco Iannelli, Francesco Santoro, Maria Santagati, Jean-Denis Docquier, Elisa Lazzeri, Gabiria Pastore, Marco Cassone, Marco R. Oggioni, Gian M. Rossolini, Stefania Stefani, Gianni Pozzi
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-07-01
Series:Frontiers in Microbiology
Subjects:
ABC transporter
macrolide efflux
Φ1207.3
prophage
mef(A)
msr(D)
Online Access:https://www.frontiersin.org/article/10.3389/fmicb.2018.01670/full

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