SEMA4D/VEGF surface enhances endothelialization by diminished-glycolysis-mediated M2-like macrophage polarization
Cardiovascular disease remains the leading cause of death and morbidity worldwide. Inflammatory responses after percutaneous coronary intervention led to neoathrosclerosis and in-stent restenosis and thus increase the risk of adverse clinical outcomes. In this work, a metabolism reshaped surface is...
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| Format: | Article |
| Language: | English |
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Elsevier
2023-12-01
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| Series: | Materials Today Bio |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2590006423002922 |
| _version_ | 1797647728647340032 |
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| author | Yuanyuan Cui Xiaomei Jiang Maozhu Yang Yinglin Yuan Zili Zhou Xiang Gao Guiqing Jia Lvzhou Cao Danni Li Yanshuang Zhao Xin Zhang Gaoping Zhao |
| author_facet | Yuanyuan Cui Xiaomei Jiang Maozhu Yang Yinglin Yuan Zili Zhou Xiang Gao Guiqing Jia Lvzhou Cao Danni Li Yanshuang Zhao Xin Zhang Gaoping Zhao |
| author_sort | Yuanyuan Cui |
| collection | DOAJ |
| description | Cardiovascular disease remains the leading cause of death and morbidity worldwide. Inflammatory responses after percutaneous coronary intervention led to neoathrosclerosis and in-stent restenosis and thus increase the risk of adverse clinical outcomes. In this work, a metabolism reshaped surface is engineered, which combines the decreased glycolysis promoting, M2-like macrophage polarization, and rapid endothelialization property. Anionic heparin plays as a linker and mediates cationic SEMA4D and VEGF to graft electronically onto PLL surfaces. The system composed by anticoagulant heparin, immunoregulatory SEMA4D and angiogenic VEGF endows the scaffold with significant inhibition of platelets, fibrinogen and anti-thrombogenic properties, also noteworthy immunometabolism reprogram, anti-inflammation M2-like polarization and finally leading to rapid endothelializaiton performances. Our research indicates that the immunometabolism method can accurately reflect the immune state of modified surfaces. It is envisioned immunometabolism study will open an avenue to the surface engineering of vascular implants for better clinical outcomes. |
| first_indexed | 2024-03-11T15:21:41Z |
| format | Article |
| id | doaj.art-02908d57bebd4b6994078716f5ab9dd0 |
| institution | Directory Open Access Journal |
| issn | 2590-0064 |
| language | English |
| last_indexed | 2024-03-11T15:21:41Z |
| publishDate | 2023-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Materials Today Bio |
| spelling | doaj.art-02908d57bebd4b6994078716f5ab9dd02023-10-28T05:09:36ZengElsevierMaterials Today Bio2590-00642023-12-0123100832SEMA4D/VEGF surface enhances endothelialization by diminished-glycolysis-mediated M2-like macrophage polarizationYuanyuan Cui0Xiaomei Jiang1Maozhu Yang2Yinglin Yuan3Zili Zhou4Xiang Gao5Guiqing Jia6Lvzhou Cao7Danni Li8Yanshuang Zhao9Xin Zhang10Gaoping Zhao11Department of Gastrointestinal Surgery, Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, 610072, China; Clinical Immunology Translational Medicine Key Laboratory of Sichuan Province, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, 610072, ChinaDepartment of Gastrointestinal Surgery, Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, 610072, ChinaClinical Immunology Translational Medicine Key Laboratory of Sichuan Province, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, 610072, ChinaDepartment of Gastrointestinal Surgery, Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, 610072, ChinaDepartment of Gastrointestinal Surgery, Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, 610072, ChinaDepartment of Gastrointestinal Surgery, Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, 610072, ChinaDepartment of Gastrointestinal Surgery, Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, 610072, ChinaDepartment of Gastrointestinal Surgery, Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, 610072, ChinaDepartment of Pharmacy, Longquanyi District of Chengdu Maternity & Child Health Care Hospital, Chengdu, 610072, ChinaDepartment of Pharmacy, The People's Hospital of Leshan, Leshan, ChinaSchool of Mechanical and Electrical Engineering, University of Electronic Science and Technology of China, Chengdu, 610072, ChinaDepartment of Gastrointestinal Surgery, Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, 610072, China; Clinical Immunology Translational Medicine Key Laboratory of Sichuan Province, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, 610072, China; Corresponding author. Department of Gastrointestinal Surgery, Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, 610072, China.Cardiovascular disease remains the leading cause of death and morbidity worldwide. Inflammatory responses after percutaneous coronary intervention led to neoathrosclerosis and in-stent restenosis and thus increase the risk of adverse clinical outcomes. In this work, a metabolism reshaped surface is engineered, which combines the decreased glycolysis promoting, M2-like macrophage polarization, and rapid endothelialization property. Anionic heparin plays as a linker and mediates cationic SEMA4D and VEGF to graft electronically onto PLL surfaces. The system composed by anticoagulant heparin, immunoregulatory SEMA4D and angiogenic VEGF endows the scaffold with significant inhibition of platelets, fibrinogen and anti-thrombogenic properties, also noteworthy immunometabolism reprogram, anti-inflammation M2-like polarization and finally leading to rapid endothelializaiton performances. Our research indicates that the immunometabolism method can accurately reflect the immune state of modified surfaces. It is envisioned immunometabolism study will open an avenue to the surface engineering of vascular implants for better clinical outcomes.http://www.sciencedirect.com/science/article/pii/S2590006423002922Semaphorin 4D (SEMA4D)Vascular endothelial growth factor (VEGF)EndothelializationImmunometabolismM2-like macrophage phenotype |
| spellingShingle | Yuanyuan Cui Xiaomei Jiang Maozhu Yang Yinglin Yuan Zili Zhou Xiang Gao Guiqing Jia Lvzhou Cao Danni Li Yanshuang Zhao Xin Zhang Gaoping Zhao SEMA4D/VEGF surface enhances endothelialization by diminished-glycolysis-mediated M2-like macrophage polarization Materials Today Bio Semaphorin 4D (SEMA4D) Vascular endothelial growth factor (VEGF) Endothelialization Immunometabolism M2-like macrophage phenotype |
| title | SEMA4D/VEGF surface enhances endothelialization by diminished-glycolysis-mediated M2-like macrophage polarization |
| title_full | SEMA4D/VEGF surface enhances endothelialization by diminished-glycolysis-mediated M2-like macrophage polarization |
| title_fullStr | SEMA4D/VEGF surface enhances endothelialization by diminished-glycolysis-mediated M2-like macrophage polarization |
| title_full_unstemmed | SEMA4D/VEGF surface enhances endothelialization by diminished-glycolysis-mediated M2-like macrophage polarization |
| title_short | SEMA4D/VEGF surface enhances endothelialization by diminished-glycolysis-mediated M2-like macrophage polarization |
| title_sort | sema4d vegf surface enhances endothelialization by diminished glycolysis mediated m2 like macrophage polarization |
| topic | Semaphorin 4D (SEMA4D) Vascular endothelial growth factor (VEGF) Endothelialization Immunometabolism M2-like macrophage phenotype |
| url | http://www.sciencedirect.com/science/article/pii/S2590006423002922 |
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