In-depth analysis of laboratory parameters reveals the interplay between sex, age, and systemic inflammation in individuals with COVID-19
Background: The progression and severity of COVID-19 vary significantly in the population. While the hallmarks of SARS-CoV-2 and severe COVID-19 within routine laboratory parameters are emerging, the impact of sex and age on these profiles is still unknown. Methods: A multidimensional analysis was p...
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| Format: | Article |
| Language: | English |
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Elsevier
2021-04-01
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| Series: | International Journal of Infectious Diseases |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1201971221002332 |
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| author | Felipe ten-Caten Patrícia Gonzalez-Dias Ícaro Castro Rodrigo L.T. Ogava Jeevan Giddaluru Juan Carlo S. Silva Felipe Martins André N.A. Gonçalves André G. Costa-Martins José D. Araujo Ana Carolina Viegas Fernando Q. Cunha Sandra Farsky Fernando A. Bozza Anna S. Levin Pia S. Pannaraj Thushan I. de Silva Paola Minoprio Fabiano Pinheiro da Silva Bruno B. Andrade Helder I. Nakaya |
| author_facet | Felipe ten-Caten Patrícia Gonzalez-Dias Ícaro Castro Rodrigo L.T. Ogava Jeevan Giddaluru Juan Carlo S. Silva Felipe Martins André N.A. Gonçalves André G. Costa-Martins José D. Araujo Ana Carolina Viegas Fernando Q. Cunha Sandra Farsky Fernando A. Bozza Anna S. Levin Pia S. Pannaraj Thushan I. de Silva Paola Minoprio Fabiano Pinheiro da Silva Bruno B. Andrade Helder I. Nakaya |
| author_sort | Felipe ten-Caten |
| collection | DOAJ |
| description | Background: The progression and severity of COVID-19 vary significantly in the population. While the hallmarks of SARS-CoV-2 and severe COVID-19 within routine laboratory parameters are emerging, the impact of sex and age on these profiles is still unknown. Methods: A multidimensional analysis was performed involving millions of records of laboratory parameters and diagnostic tests for 178 887 individuals from Brazil, of whom 33 266 tested positive for SARS-CoV-2. Analyzed data included those relating to complete blood cell count, electrolytes, metabolites, arterial blood gases, enzymes, hormones, cancer biomarkers, and others. Findings: COVID-19 induced similar alterations in laboratory parameters in males and females. CRP and ferritin were increased, especially in older men with COVID-19, whereas abnormal liver function tests were common across several age groups, except for young women. Low peripheral blood basophils and eosinophils were more common in the elderly with COVID-19. Both male and female COVID-19 patients admitted to intensive care units displayed alterations in the coagulation system, and higher values for neutrophils, CRP, and lactate dehydrogenase. Conclusions: Our study uncovered the laboratory profiles of a large cohort of COVID-19 patients, which formed the basis of discrepancies influenced by aging and biological sex. These profiles directly linked COVID-19 disease presentation to an intricate interplay between sex, age, and immune activation. |
| first_indexed | 2024-12-17T08:28:57Z |
| format | Article |
| id | doaj.art-0293cba9ba5940a4b67037204b1d3de2 |
| institution | Directory Open Access Journal |
| issn | 1201-9712 |
| language | English |
| last_indexed | 2024-12-17T08:28:57Z |
| publishDate | 2021-04-01 |
| publisher | Elsevier |
| record_format | Article |
| series | International Journal of Infectious Diseases |
| spelling | doaj.art-0293cba9ba5940a4b67037204b1d3de22022-12-21T21:56:40ZengElsevierInternational Journal of Infectious Diseases1201-97122021-04-01105579587In-depth analysis of laboratory parameters reveals the interplay between sex, age, and systemic inflammation in individuals with COVID-19Felipe ten-Caten0Patrícia Gonzalez-Dias1Ícaro Castro2Rodrigo L.T. Ogava3Jeevan Giddaluru4Juan Carlo S. Silva5Felipe Martins6André N.A. Gonçalves7André G. Costa-Martins8José D. Araujo9Ana Carolina Viegas10Fernando Q. Cunha11Sandra Farsky12Fernando A. Bozza13Anna S. Levin14Pia S. Pannaraj15Thushan I. de Silva16Paola Minoprio17Fabiano Pinheiro da Silva18Bruno B. Andrade19Helder I. Nakaya20Department of Infectious and Parasitic Diseases, University of São Paulo Medical School, University of São Paulo, São Paulo, BrazilDepartment of Clinical and Toxicological Analyses, School of Pharmaceutical Sciences, University of São Paulo, São Paulo, BrazilDepartment of Clinical and Toxicological Analyses, School of Pharmaceutical Sciences, University of São Paulo, São Paulo, BrazilDepartment of Clinical and Toxicological Analyses, School of Pharmaceutical Sciences, University of São Paulo, São Paulo, BrazilDepartment of Clinical and Toxicological Analyses, School of Pharmaceutical Sciences, University of São Paulo, São Paulo, BrazilDepartment of Clinical and Toxicological Analyses, School of Pharmaceutical Sciences, University of São Paulo, São Paulo, BrazilDepartment of Clinical and Toxicological Analyses, School of Pharmaceutical Sciences, University of São Paulo, São Paulo, BrazilDepartment of Clinical and Toxicological Analyses, School of Pharmaceutical Sciences, University of São Paulo, São Paulo, Brazil; Scientific Platform Pasteur-University of São Paulo, São Paulo, BrazilDepartment of Clinical and Toxicological Analyses, School of Pharmaceutical Sciences, University of São Paulo, São Paulo, Brazil; Scientific Platform Pasteur-University of São Paulo, São Paulo, BrazilDepartment of Clinical and Toxicological Analyses, School of Pharmaceutical Sciences, University of São Paulo, São Paulo, BrazilDivision of Nephrology, Medicine Department, School of Medicine, Federal University of São Paulo, São Paulo, BrazilCenter of Research in Inflammatory Diseases (CRID), University of São Paulo, Ribeirao Preto, São Paulo, BrazilDepartment of Clinical and Toxicological Analyses, School of Pharmaceutical Sciences, University of São Paulo, São Paulo, BrazilD’Or Institute for Research and Education, BrazilDepartment of Infectious Diseases, Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, São Paulo, BrazilDivision of Infectious Diseases, Children’s Hospital Los Angeles and Department of Pediatrics, Molecular Microbiology and Immunology, Keck School of Medicine, University of Southern California, Los Angeles, USAThe Florey Institute for Host–Pathogen Interactions and Department of Infection, Immunity and Cardiovascular Disease, The University of Sheffield, Sheffield, UKScientific Platform Pasteur-University of São Paulo, São Paulo, BrazilDepartamento de Emergências Clínicas, Faculdade de Medicina da Universidade de São Paulo, São Paulo, BrazilInstituto Gonçalo Moniz, Fundação Oswaldo Cruz, Salvador, 40296-710, Brazil; Corresponding author at: Laboratório de Inflamação e Biomarcadores, Instituto Gonçalo Moniz, Fundação Oswaldo Cruz, Rua Waldemar Falcão, 121, Candeal, Salvador, 40296-710, Brazil.Department of Clinical and Toxicological Analyses, School of Pharmaceutical Sciences, University of São Paulo, São Paulo, Brazil; Scientific Platform Pasteur-University of São Paulo, São Paulo, Brazil; Center of Research in Inflammatory Diseases (CRID), University of São Paulo, Ribeirao Preto, São Paulo, Brazil; Corresponding author at: Faculdade de Ciências Farmacêuticas, Universidade de São Paulo, Av. Lineu Prestes, 580, Bl17 Butantã, 05508900, São Paulo, Brazil.Background: The progression and severity of COVID-19 vary significantly in the population. While the hallmarks of SARS-CoV-2 and severe COVID-19 within routine laboratory parameters are emerging, the impact of sex and age on these profiles is still unknown. Methods: A multidimensional analysis was performed involving millions of records of laboratory parameters and diagnostic tests for 178 887 individuals from Brazil, of whom 33 266 tested positive for SARS-CoV-2. Analyzed data included those relating to complete blood cell count, electrolytes, metabolites, arterial blood gases, enzymes, hormones, cancer biomarkers, and others. Findings: COVID-19 induced similar alterations in laboratory parameters in males and females. CRP and ferritin were increased, especially in older men with COVID-19, whereas abnormal liver function tests were common across several age groups, except for young women. Low peripheral blood basophils and eosinophils were more common in the elderly with COVID-19. Both male and female COVID-19 patients admitted to intensive care units displayed alterations in the coagulation system, and higher values for neutrophils, CRP, and lactate dehydrogenase. Conclusions: Our study uncovered the laboratory profiles of a large cohort of COVID-19 patients, which formed the basis of discrepancies influenced by aging and biological sex. These profiles directly linked COVID-19 disease presentation to an intricate interplay between sex, age, and immune activation.http://www.sciencedirect.com/science/article/pii/S1201971221002332COVID-19NeutrophilsSex differencesCoagulopathyInfection |
| spellingShingle | Felipe ten-Caten Patrícia Gonzalez-Dias Ícaro Castro Rodrigo L.T. Ogava Jeevan Giddaluru Juan Carlo S. Silva Felipe Martins André N.A. Gonçalves André G. Costa-Martins José D. Araujo Ana Carolina Viegas Fernando Q. Cunha Sandra Farsky Fernando A. Bozza Anna S. Levin Pia S. Pannaraj Thushan I. de Silva Paola Minoprio Fabiano Pinheiro da Silva Bruno B. Andrade Helder I. Nakaya In-depth analysis of laboratory parameters reveals the interplay between sex, age, and systemic inflammation in individuals with COVID-19 International Journal of Infectious Diseases COVID-19 Neutrophils Sex differences Coagulopathy Infection |
| title | In-depth analysis of laboratory parameters reveals the interplay between sex, age, and systemic inflammation in individuals with COVID-19 |
| title_full | In-depth analysis of laboratory parameters reveals the interplay between sex, age, and systemic inflammation in individuals with COVID-19 |
| title_fullStr | In-depth analysis of laboratory parameters reveals the interplay between sex, age, and systemic inflammation in individuals with COVID-19 |
| title_full_unstemmed | In-depth analysis of laboratory parameters reveals the interplay between sex, age, and systemic inflammation in individuals with COVID-19 |
| title_short | In-depth analysis of laboratory parameters reveals the interplay between sex, age, and systemic inflammation in individuals with COVID-19 |
| title_sort | in depth analysis of laboratory parameters reveals the interplay between sex age and systemic inflammation in individuals with covid 19 |
| topic | COVID-19 Neutrophils Sex differences Coagulopathy Infection |
| url | http://www.sciencedirect.com/science/article/pii/S1201971221002332 |
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