<i>Mastomys</i> Species as Model Systems for Infectious Diseases
Replacements of animal models by advanced in vitro systems in biomedical research, despite exceptions, are currently still not satisfactory in reproducing the whole complexity of pathophysiological mechanisms that finally lead to disease. Therefore, preclinical models are additionally required to re...
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2019-02-01
|
| Series: | Viruses |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1999-4915/11/2/182 |
| _version_ | 1819168297827958784 |
|---|---|
| author | Daniel Hasche Frank Rösl |
| author_facet | Daniel Hasche Frank Rösl |
| author_sort | Daniel Hasche |
| collection | DOAJ |
| description | Replacements of animal models by advanced in vitro systems in biomedical research, despite exceptions, are currently still not satisfactory in reproducing the whole complexity of pathophysiological mechanisms that finally lead to disease. Therefore, preclinical models are additionally required to reflect analogous in vivo situations as found in humans. Despite proven limitations of both approaches, only a combined experimental arrangement guarantees generalizability of results and their transfer to the clinics. Although the laboratory mouse still stands as a paradigm for many scientific discoveries and breakthroughs, it is mandatory to broaden our view by also using nontraditional animal models. The present review will first reflect the value of experimental systems in life science and subsequently describes the preclinical rodent model <i>Mastomys coucha</i> that—although still not well known in the scientific community—has a long history in research of parasites, bacteria, papillomaviruses and cancer. Using <i>Mastomys</i>, we could recently show for the first time that cutaneous papillomaviruses—in conjunction with UV as an environmental risk factor—induce squamous cell carcinomas of the skin via a “hit-and-run„ mechanism. Moreover, <i>Mastomys coucha</i> was also used as a proof-of-principle model for the successful vaccination against non-melanoma skin cancer even under immunosuppressive conditions. |
| first_indexed | 2024-12-22T19:01:22Z |
| format | Article |
| id | doaj.art-0295906933674f46a63b93355fe21625 |
| institution | Directory Open Access Journal |
| issn | 1999-4915 |
| language | English |
| last_indexed | 2024-12-22T19:01:22Z |
| publishDate | 2019-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Viruses |
| spelling | doaj.art-0295906933674f46a63b93355fe216252022-12-21T18:15:56ZengMDPI AGViruses1999-49152019-02-0111218210.3390/v11020182v11020182<i>Mastomys</i> Species as Model Systems for Infectious DiseasesDaniel Hasche0Frank Rösl1Division Viral Transformation Mechanisms, Research Program “Infection, Inflammation and Cancer”, German Cancer Research Center, 69120 Heidelberg, GermanyDivision Viral Transformation Mechanisms, Research Program “Infection, Inflammation and Cancer”, German Cancer Research Center, 69120 Heidelberg, GermanyReplacements of animal models by advanced in vitro systems in biomedical research, despite exceptions, are currently still not satisfactory in reproducing the whole complexity of pathophysiological mechanisms that finally lead to disease. Therefore, preclinical models are additionally required to reflect analogous in vivo situations as found in humans. Despite proven limitations of both approaches, only a combined experimental arrangement guarantees generalizability of results and their transfer to the clinics. Although the laboratory mouse still stands as a paradigm for many scientific discoveries and breakthroughs, it is mandatory to broaden our view by also using nontraditional animal models. The present review will first reflect the value of experimental systems in life science and subsequently describes the preclinical rodent model <i>Mastomys coucha</i> that—although still not well known in the scientific community—has a long history in research of parasites, bacteria, papillomaviruses and cancer. Using <i>Mastomys</i>, we could recently show for the first time that cutaneous papillomaviruses—in conjunction with UV as an environmental risk factor—induce squamous cell carcinomas of the skin via a “hit-and-run„ mechanism. Moreover, <i>Mastomys coucha</i> was also used as a proof-of-principle model for the successful vaccination against non-melanoma skin cancer even under immunosuppressive conditions.https://www.mdpi.com/1999-4915/11/2/182<i>Mastomys coucha</i>animal modelspapillomavirusparasitescancer |
| spellingShingle | Daniel Hasche Frank Rösl <i>Mastomys</i> Species as Model Systems for Infectious Diseases Viruses <i>Mastomys coucha</i> animal models papillomavirus parasites cancer |
| title | <i>Mastomys</i> Species as Model Systems for Infectious Diseases |
| title_full | <i>Mastomys</i> Species as Model Systems for Infectious Diseases |
| title_fullStr | <i>Mastomys</i> Species as Model Systems for Infectious Diseases |
| title_full_unstemmed | <i>Mastomys</i> Species as Model Systems for Infectious Diseases |
| title_short | <i>Mastomys</i> Species as Model Systems for Infectious Diseases |
| title_sort | i mastomys i species as model systems for infectious diseases |
| topic | <i>Mastomys coucha</i> animal models papillomavirus parasites cancer |
| url | https://www.mdpi.com/1999-4915/11/2/182 |
| work_keys_str_mv | AT danielhasche imastomysispeciesasmodelsystemsforinfectiousdiseases AT frankrosl imastomysispeciesasmodelsystemsforinfectiousdiseases |