IκBα polymorphism at promoter region (rs2233408) influences the susceptibility of gastric cancer in Chinese
<p>Abstract</p> <p>Background</p> <p>Nuclear factor of kappa B inhibitor alpha (IκBα) protein is implicated in regulating a variety of cellular process from inflammation to tumorigenesis. The objective of this study was to investigate the susceptibility of rs2233408 T/C...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2010-02-01
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| Series: | BMC Gastroenterology |
| Online Access: | http://www.biomedcentral.com/1471-230X/10/15 |
| _version_ | 1811267169677213696 |
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| author | Sung Joseph JY Hu Pinjin Fan Daiming Chen Minhu Wu Kaichun Zeng Zhirong Zhang Mingdong Tian Linwei Wang Shiyan Yu Jun |
| author_facet | Sung Joseph JY Hu Pinjin Fan Daiming Chen Minhu Wu Kaichun Zeng Zhirong Zhang Mingdong Tian Linwei Wang Shiyan Yu Jun |
| author_sort | Sung Joseph JY |
| collection | DOAJ |
| description | <p>Abstract</p> <p>Background</p> <p>Nuclear factor of kappa B inhibitor alpha (IκBα) protein is implicated in regulating a variety of cellular process from inflammation to tumorigenesis. The objective of this study was to investigate the susceptibility of rs2233408 T/C genotype in the promoter region of <it>IκBα </it>to gastric cancer and the association of this polymorphism with clinicopathologic variables in gastric cancer patients.</p> <p>Methods</p> <p>A population-based case-control study was conducted between 1999 and 2006 in Guangdong Province, China. A total of 564 gastric cancer patients and 566 healthy controls were enrolled in this study. rs2233408 genotypes in <it>IκBα </it>were analyzed by TaqMan SNP genotyping assay.</p> <p>Results</p> <p>Both rs2233408 T homozygote (TT) and T heterozygotes (TC and TT) had significantly reduced gastric cancer risk (TT: OR = 0.250, 95% CI = 0.069-0.909, <it>P </it>= 0.035; TC and TT: OR = 0.721, 95% CI = 0.530-0.981, <it>P </it>= 0.037), compared with rs2233408 C homozygote (CC). rs2233408 T heterozygotes were significantly associated with reduced risk of intestinal-type gastric cancer with ORs of 0.648 (95% CI = 0.459-0.916, <it>P </it>= 0.014), but not with the diffuse or mix type of gastric cancer. The association between rs2233408 T heterozygotes and gastric cancer appeared more apparent in the older patients (age>40) (OR = 0.674, 95% CI = 0.484-0.939, <it>P </it>= 0.02). rs2233408 T heterozygotes was associated with non-cardiac gastric cancer (OR = 0.594, 95% CI = 0.411-0.859, <it>P </it>= 0.006), but not with cardiac gastric cancer. However, rs2233408 polymorphism was not associated with the prognosis of gastric cancer patients.</p> <p>Conclusions</p> <p><it>IκBα </it>rs2233408 T heterozygotes were associated with reduced risk of gastric cancer, especially for the development of certain subtypes of gastric cancer in Chinese population.</p> |
| first_indexed | 2024-04-12T20:56:32Z |
| format | Article |
| id | doaj.art-0296371c07f54ac59b1a1f118ccc3315 |
| institution | Directory Open Access Journal |
| issn | 1471-230X |
| language | English |
| last_indexed | 2024-04-12T20:56:32Z |
| publishDate | 2010-02-01 |
| publisher | BMC |
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| series | BMC Gastroenterology |
| spelling | doaj.art-0296371c07f54ac59b1a1f118ccc33152022-12-22T03:16:57ZengBMCBMC Gastroenterology1471-230X2010-02-011011510.1186/1471-230X-10-15IκBα polymorphism at promoter region (rs2233408) influences the susceptibility of gastric cancer in ChineseSung Joseph JYHu PinjinFan DaimingChen MinhuWu KaichunZeng ZhirongZhang MingdongTian LinweiWang ShiyanYu Jun<p>Abstract</p> <p>Background</p> <p>Nuclear factor of kappa B inhibitor alpha (IκBα) protein is implicated in regulating a variety of cellular process from inflammation to tumorigenesis. The objective of this study was to investigate the susceptibility of rs2233408 T/C genotype in the promoter region of <it>IκBα </it>to gastric cancer and the association of this polymorphism with clinicopathologic variables in gastric cancer patients.</p> <p>Methods</p> <p>A population-based case-control study was conducted between 1999 and 2006 in Guangdong Province, China. A total of 564 gastric cancer patients and 566 healthy controls were enrolled in this study. rs2233408 genotypes in <it>IκBα </it>were analyzed by TaqMan SNP genotyping assay.</p> <p>Results</p> <p>Both rs2233408 T homozygote (TT) and T heterozygotes (TC and TT) had significantly reduced gastric cancer risk (TT: OR = 0.250, 95% CI = 0.069-0.909, <it>P </it>= 0.035; TC and TT: OR = 0.721, 95% CI = 0.530-0.981, <it>P </it>= 0.037), compared with rs2233408 C homozygote (CC). rs2233408 T heterozygotes were significantly associated with reduced risk of intestinal-type gastric cancer with ORs of 0.648 (95% CI = 0.459-0.916, <it>P </it>= 0.014), but not with the diffuse or mix type of gastric cancer. The association between rs2233408 T heterozygotes and gastric cancer appeared more apparent in the older patients (age>40) (OR = 0.674, 95% CI = 0.484-0.939, <it>P </it>= 0.02). rs2233408 T heterozygotes was associated with non-cardiac gastric cancer (OR = 0.594, 95% CI = 0.411-0.859, <it>P </it>= 0.006), but not with cardiac gastric cancer. However, rs2233408 polymorphism was not associated with the prognosis of gastric cancer patients.</p> <p>Conclusions</p> <p><it>IκBα </it>rs2233408 T heterozygotes were associated with reduced risk of gastric cancer, especially for the development of certain subtypes of gastric cancer in Chinese population.</p>http://www.biomedcentral.com/1471-230X/10/15 |
| spellingShingle | Sung Joseph JY Hu Pinjin Fan Daiming Chen Minhu Wu Kaichun Zeng Zhirong Zhang Mingdong Tian Linwei Wang Shiyan Yu Jun IκBα polymorphism at promoter region (rs2233408) influences the susceptibility of gastric cancer in Chinese BMC Gastroenterology |
| title | IκBα polymorphism at promoter region (rs2233408) influences the susceptibility of gastric cancer in Chinese |
| title_full | IκBα polymorphism at promoter region (rs2233408) influences the susceptibility of gastric cancer in Chinese |
| title_fullStr | IκBα polymorphism at promoter region (rs2233408) influences the susceptibility of gastric cancer in Chinese |
| title_full_unstemmed | IκBα polymorphism at promoter region (rs2233408) influences the susceptibility of gastric cancer in Chinese |
| title_short | IκBα polymorphism at promoter region (rs2233408) influences the susceptibility of gastric cancer in Chinese |
| title_sort | iκbα polymorphism at promoter region rs2233408 influences the susceptibility of gastric cancer in chinese |
| url | http://www.biomedcentral.com/1471-230X/10/15 |
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