Biphenotypic sinonasal sarcoma with PAX3/FOXO1 fusion
Biphenotypic sinonasal sarcoma (BSNS), previously known as low-grade sinonasal sarcoma, is a rare tumour of the sinonasal tract, first described in 2012. It involves both myogenic and neural differentiation and is characterized by PAX3 rearrangement. MAML3 is the most frequent fusion partner of PAX3...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Termedia Publishing House
2024-02-01
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| Series: | Polish Journal of Pathology |
| Subjects: | |
| Online Access: | https://www.termedia.pl/Biphenotypic-sinonasal-sarcoma-with-PAX3-FOXO1-fusion,55,52242,1,1.html |
| _version_ | 1797333199942057984 |
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| author | Ilkay Tosun Murat H. Karabulut Ismail Yilmaz Ahmet A. Cırık Onur Sahin |
| author_facet | Ilkay Tosun Murat H. Karabulut Ismail Yilmaz Ahmet A. Cırık Onur Sahin |
| author_sort | Ilkay Tosun |
| collection | DOAJ |
| description | Biphenotypic sinonasal sarcoma (BSNS), previously known as low-grade sinonasal sarcoma, is a rare tumour of the sinonasal tract, first described in 2012. It involves both myogenic and neural differentiation and is characterized by PAX3 rearrangement. MAML3 is the most frequent fusion partner of PAX3; however, its partner remains unidentified in a subset of cases. These tumours have significant local recurrence rates but lack metastatic potential. Here, we report a case of BSNS with PAX3/FOXO1 fusion and discuss its clinicopathological features and differential diagnosis. |
| first_indexed | 2024-03-08T08:01:14Z |
| format | Article |
| id | doaj.art-02972becac074f7eb9845af2bbcf92b5 |
| institution | Directory Open Access Journal |
| issn | 1233-9687 2084-9869 |
| language | English |
| last_indexed | 2024-03-08T08:01:14Z |
| publishDate | 2024-02-01 |
| publisher | Termedia Publishing House |
| record_format | Article |
| series | Polish Journal of Pathology |
| spelling | doaj.art-02972becac074f7eb9845af2bbcf92b52024-02-02T12:10:24ZengTermedia Publishing HousePolish Journal of Pathology1233-96872084-98692024-02-0174428228510.5114/pjp.2023.13432152242Biphenotypic sinonasal sarcoma with PAX3/FOXO1 fusionIlkay TosunMurat H. KarabulutIsmail YilmazAhmet A. CırıkOnur SahinBiphenotypic sinonasal sarcoma (BSNS), previously known as low-grade sinonasal sarcoma, is a rare tumour of the sinonasal tract, first described in 2012. It involves both myogenic and neural differentiation and is characterized by PAX3 rearrangement. MAML3 is the most frequent fusion partner of PAX3; however, its partner remains unidentified in a subset of cases. These tumours have significant local recurrence rates but lack metastatic potential. Here, we report a case of BSNS with PAX3/FOXO1 fusion and discuss its clinicopathological features and differential diagnosis.https://www.termedia.pl/Biphenotypic-sinonasal-sarcoma-with-PAX3-FOXO1-fusion,55,52242,1,1.htmlbiphenotypic sinonasal sarcoma pax3/foxo1 low-grade neoplasia. |
| spellingShingle | Ilkay Tosun Murat H. Karabulut Ismail Yilmaz Ahmet A. Cırık Onur Sahin Biphenotypic sinonasal sarcoma with PAX3/FOXO1 fusion Polish Journal of Pathology biphenotypic sinonasal sarcoma pax3/foxo1 low-grade neoplasia. |
| title | Biphenotypic sinonasal sarcoma with PAX3/FOXO1 fusion |
| title_full | Biphenotypic sinonasal sarcoma with PAX3/FOXO1 fusion |
| title_fullStr | Biphenotypic sinonasal sarcoma with PAX3/FOXO1 fusion |
| title_full_unstemmed | Biphenotypic sinonasal sarcoma with PAX3/FOXO1 fusion |
| title_short | Biphenotypic sinonasal sarcoma with PAX3/FOXO1 fusion |
| title_sort | biphenotypic sinonasal sarcoma with pax3 foxo1 fusion |
| topic | biphenotypic sinonasal sarcoma pax3/foxo1 low-grade neoplasia. |
| url | https://www.termedia.pl/Biphenotypic-sinonasal-sarcoma-with-PAX3-FOXO1-fusion,55,52242,1,1.html |
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