Factors associated with clinically relevant drug-drug interactions with statins in outpatients with coronary artery disease
The concomitant use of statins with other drugs is quite common and contributes to an increased risk of drug interactions that may become manifested clinically as adverse drug reactions. The objective of the study was to determine the factors associated with clinically relevant drug interactions wit...
| Principais autores: | , , , |
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| Formato: | Artigo |
| Idioma: | English |
| Publicado em: |
Centro Universitário São Camilo
2020-10-01
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| coleção: | O Mundo da Saúde |
| Assuntos: | |
| Acesso em linha: | https://revistamundodasaude.emnuvens.com.br/mundodasaude/article/view/978 |
| _version_ | 1827127591184629760 |
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| author | Jéssica Nathália Domingos dos Santos Ronara Camila Souza Groia Veloso Marlon Silva Tinoco Adriano Max Moreira Reis |
| author_facet | Jéssica Nathália Domingos dos Santos Ronara Camila Souza Groia Veloso Marlon Silva Tinoco Adriano Max Moreira Reis |
| author_sort | Jéssica Nathália Domingos dos Santos |
| collection | DOAJ |
| description | The concomitant use of statins with other drugs is quite common and contributes to an increased risk of drug interactions
that may become manifested clinically as adverse drug reactions. The objective of the study was to determine the
factors associated with clinically relevant drug interactions with drug-drug statins in patients seen at the multiprofessional
cardiology outpatient clinic of a university hospital. This was a cross-sectional study conducted with 148 patients.
The dependent variable was whether or not there were clinically relevant drug interactions with statins according to
the Scientific Statement from the American Heart Association. A logistic regression was performed to analyze the
association of the occurrence of clinically relevant drug interactions with statins and independent variables. The median
number of drugs used was seven (IQR=3) and the number of cardiovascular drugs was five (IQR=2), where 91.2%
(n=135) had polypharmacy. The most prevalent diseases in the studied population were systemic arterial hypertension
and dyslipidemia. The median number of diseases was five. The prevalence of clinically relevant drug interactions with
statins was 43.2%. A positive association was identified between clinically relevant drug interactions with statins and the
number of diseases (OR=4.025; CI=1.895-8.553). All potential drug interactions with simvastatin found were of clinical
relevance. The most prevalent interactions were: amlodipine + simvastatin and warfarin + simvastatin. The identification
of factors associated with drug interactions allows directing measures to prevent adverse events in more exposed
populations, such as those with multiple comorbidities. |
| first_indexed | 2024-03-11T19:47:05Z |
| format | Article |
| id | doaj.art-0297a33030dd4885b79e96ee161ac65e |
| institution | Directory Open Access Journal |
| issn | 0104-7809 1980-3990 |
| language | English |
| last_indexed | 2025-03-20T15:30:56Z |
| publishDate | 2020-10-01 |
| publisher | Centro Universitário São Camilo |
| record_format | Article |
| series | O Mundo da Saúde |
| spelling | doaj.art-0297a33030dd4885b79e96ee161ac65e2024-09-03T19:56:00ZengCentro Universitário São CamiloO Mundo da Saúde0104-78091980-39902020-10-0144506514896Factors associated with clinically relevant drug-drug interactions with statins in outpatients with coronary artery diseaseJéssica Nathália Domingos dos Santos0Ronara Camila Souza Groia Veloso1Marlon Silva Tinoco2Adriano Max Moreira Reis3Universidade Federal de Minas Gerais – UFMG. Belo Horizonte / MG, Brasil.Universidade Federal de Minas Gerais – UFMG. Belo Horizonte / MG, Brasil.Universidade Federal de Minas Gerais – UFMG. Belo Horizonte / MG, Brasil.Universidade Federal de Minas Gerais – UFMG. Belo Horizonte / MG, Brasil.The concomitant use of statins with other drugs is quite common and contributes to an increased risk of drug interactions that may become manifested clinically as adverse drug reactions. The objective of the study was to determine the factors associated with clinically relevant drug interactions with drug-drug statins in patients seen at the multiprofessional cardiology outpatient clinic of a university hospital. This was a cross-sectional study conducted with 148 patients. The dependent variable was whether or not there were clinically relevant drug interactions with statins according to the Scientific Statement from the American Heart Association. A logistic regression was performed to analyze the association of the occurrence of clinically relevant drug interactions with statins and independent variables. The median number of drugs used was seven (IQR=3) and the number of cardiovascular drugs was five (IQR=2), where 91.2% (n=135) had polypharmacy. The most prevalent diseases in the studied population were systemic arterial hypertension and dyslipidemia. The median number of diseases was five. The prevalence of clinically relevant drug interactions with statins was 43.2%. A positive association was identified between clinically relevant drug interactions with statins and the number of diseases (OR=4.025; CI=1.895-8.553). All potential drug interactions with simvastatin found were of clinical relevance. The most prevalent interactions were: amlodipine + simvastatin and warfarin + simvastatin. The identification of factors associated with drug interactions allows directing measures to prevent adverse events in more exposed populations, such as those with multiple comorbidities.https://revistamundodasaude.emnuvens.com.br/mundodasaude/article/view/978drug interactions. use of medicines. statins. coronary artery disease. cardiovascular diseases. |
| spellingShingle | Jéssica Nathália Domingos dos Santos Ronara Camila Souza Groia Veloso Marlon Silva Tinoco Adriano Max Moreira Reis Factors associated with clinically relevant drug-drug interactions with statins in outpatients with coronary artery disease O Mundo da Saúde drug interactions. use of medicines. statins. coronary artery disease. cardiovascular diseases. |
| title | Factors associated with clinically relevant drug-drug interactions with statins in outpatients with coronary artery disease |
| title_full | Factors associated with clinically relevant drug-drug interactions with statins in outpatients with coronary artery disease |
| title_fullStr | Factors associated with clinically relevant drug-drug interactions with statins in outpatients with coronary artery disease |
| title_full_unstemmed | Factors associated with clinically relevant drug-drug interactions with statins in outpatients with coronary artery disease |
| title_short | Factors associated with clinically relevant drug-drug interactions with statins in outpatients with coronary artery disease |
| title_sort | factors associated with clinically relevant drug drug interactions with statins in outpatients with coronary artery disease |
| topic | drug interactions. use of medicines. statins. coronary artery disease. cardiovascular diseases. |
| url | https://revistamundodasaude.emnuvens.com.br/mundodasaude/article/view/978 |
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