Synthesis and biological evaluation of novel 1,3,4-thiadiazole derivatives as possible anticancer agents

Synthesis and biological evaluation of novel 1,3,4-thiadiazole derivatives as possible anticancer agents

The synthesis of new N-(5-substituted-1,3,4-thiadiazol-2-yl)-2-[(5-(substituted amino)-1,3,4-thiadiazol-2-yl)thio]acetamide derivatives and investigation of their anticancer activities were the aims of this work. All the new compounds’ structures were elucidated by elemental analyses, IR, 1H NMR, 13...

Full description

Bibliographic Details
Main Authors:	Çevik Ulviye Acar, Osmaniye Derya, Levent Serkan, Sağlik Begüm Nurpelin, Çavuşoğlu Betül Kaya, Karaduman Abdullah Burak, Özkay Yusuf, Kaplancikli Zafer Asim
Format:	Article
Language:	English
Published:	Sciendo 2020-12-01
Series:	Acta Pharmaceutica
Subjects:	1 3 4-thiadiazole anticancer activity aromatase inhibitory activity mtt assay
Online Access:	https://doi.org/10.2478/acph-2020-0034

Similar Items

Synthesis and characterization of a new series of thiadiazole derivatives as potential anticancer agents
by: Çevik Ulviye Acar, et al.
Published: (2020-03-01)

Synthesis and Evaluation of New 1,3,4-Thiadiazole Derivatives as Potent Antifungal Agents
by: Ahmet Çağrı Karaburun, et al.
Published: (2018-11-01)

Synthesis, Docking Studies and Biological Activity of New Benzimidazole- Triazolothiadiazine Derivatives as Aromatase Inhibitor
by: Ulviye Acar Çevik, et al.
Published: (2020-04-01)

Synthesis and Biological Evaluation of New Thiosemicarbazone Derivative Schiff Bases as Monoamine Oxidase Inhibitory Agents
by: Betül Kaya Çavuşoğlu, et al.
Published: (2017-12-01)

Design, Synthesis, and Evaluation of Novel 2<i>H</i>-Benzo[b][1,4]thiazin-3(4<i>H</i>)-one Derivatives as New Acetylcholinesterase Inhibitors
by: Sazan Haji Ali, et al.
Published: (2022-03-01)

Design, Synthesis, and Structure–Activity Relationships of Thiazole Analogs as Anticholinesterase Agents for Alzheimer’s Disease
by: Begüm Nurpelin Sağlık, et al.
Published: (2020-09-01)

Synthesis and Anticandidal Activity of New Imidazole-Chalcones
by: Derya Osmaniye, et al.
Published: (2018-04-01)

Synthesis, anticancer evaluation and molecular docking studies of new benzimidazole- 1,3,4-oxadiazole derivatives as human topoisomerase types I poison
by: Ulviye Acar Çevik, et al.
Published: (2020-01-01)

Design, Synthesis, and Biological Activity Evaluation of New Donepezil-Like Compounds Bearing Thiazole Ring for the Treatment of Alzheimer’s Disease
by: Begüm Nurpelin Sağlık, et al.
Published: (2020-07-01)

Synthesis and AChE-Inhibitory Activity of New Benzimidazole Derivatives
by: Ulviye Acar Cevik, et al.
Published: (2019-02-01)

Synthesis and Anticancer Activities of Pyrazole–Thiadiazole-Based EGFR Inhibitors
by: Berkant Kurban, et al.
Published: (2023-08-01)

Synthesis and Anticandidal Activity Evaluation of New Benzimidazole-Thiazole Derivatives
by: Zafer Asım Kaplancıklı, et al.
Published: (2017-11-01)

Design and Synthesis of New Benzothiazole Compounds as Selective hMAO-B Inhibitors
by: Sinem Ilgın, et al.
Published: (2017-12-01)

Synthesis and AChE Inhibitory Activity of Novel Thiazolylhydrazone Derivatives
by: Derya Osmaniye, et al.
Published: (2019-06-01)

Design, Synthesis, In Vitro and In Silico Studies of New Thiazolylhydrazine-Piperazine Derivatives as Selective MAO-A Inhibitors
by: Begüm Nurpelin Sağlık, et al.
Published: (2020-09-01)

Synthesis of Some Novel Thiadiazole Derivative Compounds and Screening Their Antidepressant-Like Activities
by: Nafiz Öncü Can, et al.
Published: (2018-03-01)

Synthesis, in vitro enzyme activity and molecular docking studies of new benzylamine-sulfonamide derivatives as selective MAO-B inhibitors
by: Begüm Nurpelin Sağlık, et al.
Published: (2020-01-01)

Cytotoxic Properties of 1,3,4-Thiadiazole Derivatives—A Review
by: Sara Janowska, et al.
Published: (2020-09-01)

Synthesis and Cytotoxicity Evaluation of N-(5-(Substituted-benzylthio)-1,3,4-thiadiazole-2-yl)-2-p-nitrophenylacetamide Derivatives as Potential Anticancer Agents
by: Alireza Aliabadi, et al.
Published: (2019-02-01)

Novel Thiosemicarbazone Derivatives: In Vitro and In Silico Evaluation as Potential MAO-B Inhibitors
by: Derya Osmaniye, et al.
Published: (2021-11-01)

4-Halo-N-(5-(trifluoromethyl)-1,3,4-thiadiazol-2-yl)benzamide and Benzothioamide Derivatives: Synthesis and in vitro Anticancer Assessment
by: Ali Reza Aliabadi, et al.
Published: (2020-10-01)

Preparation , charactarazition and biological activity of some complexes of potassium 2-carbomethoxy amino-5- trithiocarbonate 1,3,4-thiadiazole
by: Baghdad Science Journal
Published: (2012-09-01)

Synthesis and biological activities of 3,6-disubstituted-1,2,4-triazolo-1,3,4- thiadiazole derivatives
by: L. Lin,, et al.
Published: (2018-01-01)

Design, synthesis, and evaluation of novel 2-phenylpropionic acid derivatives as dual COX inhibitory-antibacterial agents
by: Hülya Karaca Gençer, et al.
Published: (2017-01-01)

Design, Synthesis, and Biological Effect Studies of Novel Benzofuran–Thiazolylhydrazone Derivatives as Monoamine Oxidase Inhibitors
by: Derya Osmani̇ye, et al.
Published: (2024-02-01)

New 1,3,4-Thiadiazole Derivatives with Anticancer Activity
by: Sara Janowska, et al.
Published: (2022-03-01)

Synthesis and Antimicrobial Activity of Some New 1,3,4-Thiadiazole Derivatives
by: Mohamed R. Abdel Aziz, et al.
Published: (2012-12-01)

Novel Imidazole Derivatives as Antifungal Agents: Synthesis, Biological Evaluation, ADME Prediction and Molecular Docking Studies
by: Yusuf Özkay, et al.
Published: (2017-10-01)

Synthesis and Antibacterial Activities of Novel Imidazo[2,1-b]-1,3,4-thiadiazoles
by: Kamal F. M. Atta, et al.
Published: (2011-06-01)

Novel Pyrimidine Derivatives Bearing a 1,3,4-Thiadiazole Skeleton: Design, Synthesis, and Antifungal Activity
by: Nianjuan Pan, et al.
Published: (2022-06-01)

Design, Synthesis, Antibacterial Evaluations and In Silico Studies of Novel Thiosemicarbazides and 1,3,4-Thiadiazoles
by: Sara Janowska, et al.
Published: (2022-05-01)

Diverse Biological Activities of 1,3,4-Thiadiazole Scaffold
by: Tulika Anthwal, et al.
Published: (2022-12-01)

Novel 1-(2-pyrimidin-2-yl)piperazine derivatives as selective monoamine oxidase (MAO)-A inhibitors
by: Betül Kaya, et al.
Published: (2017-01-01)

Design, Synthesis, and Biological Evaluation Studies of Novel Naphthalene-Chalcone Hybrids As Antimicrobial, Anticandidal, Anticancer, and VEGFR‑2 Inhibitors
by: Derya Osmaniye, et al.
Published: (2023-02-01)

Synthesis of New Hydrazone Derivatives for MAO Enzymes Inhibitory Activity
by: Nafiz Öncü Can, et al.
Published: (2017-08-01)

Synthesis and Anticancer Activity of 1,3,4-Thiadiazoles with 3-Methoxyphenyl Substituent
by: Sara Janowska, et al.
Published: (2022-10-01)

Synthesis and Bioactivities of Novel 1,3,4-Thiadiazole Derivatives of Glucosides
by: Meihang Chen, et al.
Published: (2021-03-01)

1,3,4-Thiadiazole Scaffold: As Anti-Epileptic Agents
by: Tulika Anthwal, et al.
Published: (2022-01-01)

Synthesis and Evaluation of Antimicrobial Activity of Tetranorlabdane Compounds Bearing 1,3,4-Thiadiazole Units
by: Svetlana Blaja, et al.
Published: (2023-06-01)

New Benzimidazole-Triazole Derivatives as Topoisomerase I Inhibitors: Design, Synthesis, Anticancer Screening, and Molecular Modeling Studies
by: Ulviye Acar Çevik, et al.
Published: (2024-03-01)