Variability and resistance mutations in the hepatitis C virus NS3 protease in patients not treated with protease inhibitors

Variability and resistance mutations in the hepatitis C virus NS3 protease in patients not treated with protease inhibitors

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The goal of treatment of chronic hepatitis C is to achieve a sustained virological response, which is defined as exhibiting undetectable hepatitis C virus (HCV) RNA levels in serum following therapy for at least six months. However, the current treatment is only effective in 50% of patients infected...

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Bibliographic Details
Main Authors: Luciana Bonome Zeminian, Juliana Lara Padovani, Sílvia Maria Corvino, Giovanni Faria Silva, Maria Inês de Moura Campos Pardini, Rejane Maria Tommasini Grotto
Format: Article
Language:English
Published: Fundação Oswaldo Cruz (FIOCRUZ) 2013-02-01
Series:Memorias do Instituto Oswaldo Cruz
Subjects:
HCV genotype 1a
NS3 protease mutations
protease inhibitors
Online Access:http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762013000100002&lng=en&tlng=en

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