Incidence of Cervical Human Papillomavirus and Cervical Intraepithelial Neoplasia in Women with Positive and Negative HIV Status
Abstract Objectives To evaluate the incidence and factors associated with cervical intraepithelial neoplasia (CIN) and cervical infection by human papillomavirus (HPV) among HIV-positive and HIV-negative women. Methods A cohort of 103 HIV positive and 113 HIV negative women were monitored betwee...
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| Format: | Article |
| Language: | English |
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Federação Brasileira das Sociedades de Ginecologia e Obstetrícia
2016-05-01
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| Series: | Revista Brasileira de Ginecologia e Obstetrícia |
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| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-72032016000500231&tlng=en |
| _version_ | 1798022284909215744 |
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| author | Benito Pio Vitorio Ceccato Junior Mark Drew Crosland Guimarães Ana Paula Ceccato Lopes Lorena Fiorini Nascimento Luísa Magalhães Novaes Dora Méndez del Castillo Victor Hugo Melo |
| author_facet | Benito Pio Vitorio Ceccato Junior Mark Drew Crosland Guimarães Ana Paula Ceccato Lopes Lorena Fiorini Nascimento Luísa Magalhães Novaes Dora Méndez del Castillo Victor Hugo Melo |
| author_sort | Benito Pio Vitorio Ceccato Junior |
| collection | DOAJ |
| description | Abstract Objectives To evaluate the incidence and factors associated with cervical intraepithelial neoplasia (CIN) and cervical infection by human papillomavirus (HPV) among HIV-positive and HIV-negative women. Methods A cohort of 103 HIV positive and 113 HIV negative women were monitored between October 2008 and February 2012, for at least one year. Procedures included cervical cytology, DNA/HPV detection by polymerase chain reaction, colposcopy with biopsy if necessary, followed by an interview for exposure characteristics data. CIN was based on the histopathological results. Results The incidence of CIN was of 8.8 and 4.6 cases/100 women-years in HIVpositive and HIV-negative women, respectively. HIV-positive women presented a hazard ratio (HR) of 2.8 for CIN and developed lesions earlier (0.86 year) than HIVnegative women (2 years) (p = 0.01). The risk of developing CIN decreased with age (HR = 0.9) and marital status (HR = 0.4). HPV patients presented a higher incidence of CIN when compared HIV-positive and HIV-negative women (p = 0.01). The incidence of HPV cervical infection was 18.1 and 11.4 cases/100 women-years in HIV-positive and HIV-negative women, respectively. Those HIV-positive presented earlier HPV infection (p = 0.002). The risk of developing HPV infection decreased with age and was higher among HIV-positive women. HPV 16 was the most common type in HIV-positive women, and also the type most closely associated with CIN in HIV-negative women. Conclusions HIV-positive women had a greater incidence of HPV and CIN, and in a shorter time interval. More rigorous and timely clinical control is required for this group. |
| first_indexed | 2024-04-11T17:27:25Z |
| format | Article |
| id | doaj.art-0298beab1ff246c987479c63402e78ba |
| institution | Directory Open Access Journal |
| issn | 0100-7203 |
| language | English |
| last_indexed | 2024-04-11T17:27:25Z |
| publishDate | 2016-05-01 |
| publisher | Federação Brasileira das Sociedades de Ginecologia e Obstetrícia |
| record_format | Article |
| series | Revista Brasileira de Ginecologia e Obstetrícia |
| spelling | doaj.art-0298beab1ff246c987479c63402e78ba2022-12-22T04:12:14ZengFederação Brasileira das Sociedades de Ginecologia e ObstetríciaRevista Brasileira de Ginecologia e Obstetrícia0100-72032016-05-0138523123810.1055/s-0036-1583294Incidence of Cervical Human Papillomavirus and Cervical Intraepithelial Neoplasia in Women with Positive and Negative HIV StatusBenito Pio Vitorio Ceccato JuniorMark Drew Crosland GuimarãesAna Paula Ceccato LopesLorena Fiorini NascimentoLuísa Magalhães NovaesDora Méndez del CastilloVictor Hugo MeloAbstract Objectives To evaluate the incidence and factors associated with cervical intraepithelial neoplasia (CIN) and cervical infection by human papillomavirus (HPV) among HIV-positive and HIV-negative women. Methods A cohort of 103 HIV positive and 113 HIV negative women were monitored between October 2008 and February 2012, for at least one year. Procedures included cervical cytology, DNA/HPV detection by polymerase chain reaction, colposcopy with biopsy if necessary, followed by an interview for exposure characteristics data. CIN was based on the histopathological results. Results The incidence of CIN was of 8.8 and 4.6 cases/100 women-years in HIVpositive and HIV-negative women, respectively. HIV-positive women presented a hazard ratio (HR) of 2.8 for CIN and developed lesions earlier (0.86 year) than HIVnegative women (2 years) (p = 0.01). The risk of developing CIN decreased with age (HR = 0.9) and marital status (HR = 0.4). HPV patients presented a higher incidence of CIN when compared HIV-positive and HIV-negative women (p = 0.01). The incidence of HPV cervical infection was 18.1 and 11.4 cases/100 women-years in HIV-positive and HIV-negative women, respectively. Those HIV-positive presented earlier HPV infection (p = 0.002). The risk of developing HPV infection decreased with age and was higher among HIV-positive women. HPV 16 was the most common type in HIV-positive women, and also the type most closely associated with CIN in HIV-negative women. Conclusions HIV-positive women had a greater incidence of HPV and CIN, and in a shorter time interval. More rigorous and timely clinical control is required for this group.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-72032016000500231&tlng=enHIV infectionsHPV DNA probespapillomavirus infectionscervical intraepithelial neoplasiapolymerase chain reaction |
| spellingShingle | Benito Pio Vitorio Ceccato Junior Mark Drew Crosland Guimarães Ana Paula Ceccato Lopes Lorena Fiorini Nascimento Luísa Magalhães Novaes Dora Méndez del Castillo Victor Hugo Melo Incidence of Cervical Human Papillomavirus and Cervical Intraepithelial Neoplasia in Women with Positive and Negative HIV Status Revista Brasileira de Ginecologia e Obstetrícia HIV infections HPV DNA probes papillomavirus infections cervical intraepithelial neoplasia polymerase chain reaction |
| title | Incidence of Cervical Human Papillomavirus and Cervical Intraepithelial Neoplasia in Women with Positive and Negative HIV Status |
| title_full | Incidence of Cervical Human Papillomavirus and Cervical Intraepithelial Neoplasia in Women with Positive and Negative HIV Status |
| title_fullStr | Incidence of Cervical Human Papillomavirus and Cervical Intraepithelial Neoplasia in Women with Positive and Negative HIV Status |
| title_full_unstemmed | Incidence of Cervical Human Papillomavirus and Cervical Intraepithelial Neoplasia in Women with Positive and Negative HIV Status |
| title_short | Incidence of Cervical Human Papillomavirus and Cervical Intraepithelial Neoplasia in Women with Positive and Negative HIV Status |
| title_sort | incidence of cervical human papillomavirus and cervical intraepithelial neoplasia in women with positive and negative hiv status |
| topic | HIV infections HPV DNA probes papillomavirus infections cervical intraepithelial neoplasia polymerase chain reaction |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-72032016000500231&tlng=en |
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