The rs2228145 Variant of the Interleukin-6 Receptor (IL-6R) Gene Impacts on In Vitro Cellular Responses to SARS-CoV-2 VOC B1.1.7 Recombinant Spike Protein

The rs2228145 Variant of the Interleukin-6 Receptor (IL-6R) Gene Impacts on In Vitro Cellular Responses to SARS-CoV-2 VOC B1.1.7 Recombinant Spike Protein

Given the variability in inflammatory responses to SARS-CoV-2 infection observed within human populations, we aimed to develop an in vitro model system (based on monocyte-macrophages, a key relevant cell type) that could yield insights regarding the impact of rs2228145, a clinically relevant polymor...

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Bibliographic Details
Main Authors: Saira Sarwar, Rebecca Aicheler, Lee Butcher, Katie Rees, Stephen Potter, Richard Rowlands, Richard Webb
Format: Article
Language:English
Published: MDPI AG 2023-10-01
Series:COVID
Subjects:
IL-6
sIL-6R
COVID-19
long-COVID
monocyte-macrophage
genetic variants
Online Access:https://www.mdpi.com/2673-8112/3/10/106

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