Diagonal earlobe crease: Prevalence and association with medical ailments
Context: It has been hypothesized that diagonal earlobe crease (DELC), “Frank's sign” is indicative of coronary artery disease (CAD) and/or diabetes mellitus (DM). Several studies have confirmed an association between DELC and cardiac morbidity, mortality, and hypertension (HTN). However, some...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2018-01-01
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| Series: | Journal of Clinical and Preventive Cardiology |
| Subjects: | |
| Online Access: | http://www.jcpconline.org/article.asp?issn=2250-3528;year=2018;volume=7;issue=2;spage=49;epage=53;aulast=Kadam |
| _version_ | 1811240686784086016 |
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| author | Yugantara Ramesh Kadam Yogesh M Shah Parth Kore |
| author_facet | Yugantara Ramesh Kadam Yogesh M Shah Parth Kore |
| author_sort | Yugantara Ramesh Kadam |
| collection | DOAJ |
| description | Context: It has been hypothesized that diagonal earlobe crease (DELC), “Frank's sign” is indicative of coronary artery disease (CAD) and/or diabetes mellitus (DM). Several studies have confirmed an association between DELC and cardiac morbidity, mortality, and hypertension (HTN). However, some studies have not found any significant association. Aims: This study aims to find out the prevalence of DELC and its association with CAD, DM, and HTN. Settings and Design: Sangli-Miraj-Kupwad Corporation area. This was a cross-sectional analytical study. Subjects and Methods: Study participants: Adults from 18 to 60 years age. Inclusion criteria: willing to participate in the study Exclusion criteria: Wearing heavy ear rings and excessive normal generalized wrinkling of the skin. Sample size: Sample size 6310, determined after a pilot study revealing DELC in 1.5%. Sampling technique: Two-stage cluster sampling. Duration of study: 6 months. Study tools: Predesigned, pilot tested pro forma. Statistical Analysis: Statistical analysis was done by using SPSS 22 software. Prevalence and percentages were calculated, and Chi-square test was applied. Results: Out of 6638 participants, 179 had DELC. The prevalence of bilateral DELC was 2.7%. The prevalence was significantly high among males (4.13%) and in the 51–60 years age group (5.29%). The prevalence of Grade 3 DELC was high and 91% of young adults had Grade 3 DELC. There were 408 (6.15%) participants who gave a history of CAD, 827 (12.46%) of DM, and 670 (10.09%) HTN. Significantly high association observed between DELC and CAD, DM, and HTN. CAD, DM, and HTN were significantly associated with Grade 3. Conclusions: The prevalence of bilateral DELC was 2.7% and is significantly associated with CAD, DM, and HTN. |
| first_indexed | 2024-04-12T13:24:40Z |
| format | Article |
| id | doaj.art-0299ac44adad4b069e1913086c74cc72 |
| institution | Directory Open Access Journal |
| issn | 2250-3528 |
| language | English |
| last_indexed | 2024-04-12T13:24:40Z |
| publishDate | 2018-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Journal of Clinical and Preventive Cardiology |
| spelling | doaj.art-0299ac44adad4b069e1913086c74cc722022-12-22T03:31:22ZengWolters Kluwer Medknow PublicationsJournal of Clinical and Preventive Cardiology2250-35282018-01-0172495310.4103/JCPC.JCPC_26_17Diagonal earlobe crease: Prevalence and association with medical ailmentsYugantara Ramesh KadamYogesh M ShahParth KoreContext: It has been hypothesized that diagonal earlobe crease (DELC), “Frank's sign” is indicative of coronary artery disease (CAD) and/or diabetes mellitus (DM). Several studies have confirmed an association between DELC and cardiac morbidity, mortality, and hypertension (HTN). However, some studies have not found any significant association. Aims: This study aims to find out the prevalence of DELC and its association with CAD, DM, and HTN. Settings and Design: Sangli-Miraj-Kupwad Corporation area. This was a cross-sectional analytical study. Subjects and Methods: Study participants: Adults from 18 to 60 years age. Inclusion criteria: willing to participate in the study Exclusion criteria: Wearing heavy ear rings and excessive normal generalized wrinkling of the skin. Sample size: Sample size 6310, determined after a pilot study revealing DELC in 1.5%. Sampling technique: Two-stage cluster sampling. Duration of study: 6 months. Study tools: Predesigned, pilot tested pro forma. Statistical Analysis: Statistical analysis was done by using SPSS 22 software. Prevalence and percentages were calculated, and Chi-square test was applied. Results: Out of 6638 participants, 179 had DELC. The prevalence of bilateral DELC was 2.7%. The prevalence was significantly high among males (4.13%) and in the 51–60 years age group (5.29%). The prevalence of Grade 3 DELC was high and 91% of young adults had Grade 3 DELC. There were 408 (6.15%) participants who gave a history of CAD, 827 (12.46%) of DM, and 670 (10.09%) HTN. Significantly high association observed between DELC and CAD, DM, and HTN. CAD, DM, and HTN were significantly associated with Grade 3. Conclusions: The prevalence of bilateral DELC was 2.7% and is significantly associated with CAD, DM, and HTN.http://www.jcpconline.org/article.asp?issn=2250-3528;year=2018;volume=7;issue=2;spage=49;epage=53;aulast=KadamCoronary artery diseasediabetes mellitusdiagonal earlobe creasehypertension |
| spellingShingle | Yugantara Ramesh Kadam Yogesh M Shah Parth Kore Diagonal earlobe crease: Prevalence and association with medical ailments Journal of Clinical and Preventive Cardiology Coronary artery disease diabetes mellitus diagonal earlobe crease hypertension |
| title | Diagonal earlobe crease: Prevalence and association with medical ailments |
| title_full | Diagonal earlobe crease: Prevalence and association with medical ailments |
| title_fullStr | Diagonal earlobe crease: Prevalence and association with medical ailments |
| title_full_unstemmed | Diagonal earlobe crease: Prevalence and association with medical ailments |
| title_short | Diagonal earlobe crease: Prevalence and association with medical ailments |
| title_sort | diagonal earlobe crease prevalence and association with medical ailments |
| topic | Coronary artery disease diabetes mellitus diagonal earlobe crease hypertension |
| url | http://www.jcpconline.org/article.asp?issn=2250-3528;year=2018;volume=7;issue=2;spage=49;epage=53;aulast=Kadam |
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