Swimming training alleviated insulin resistance through Wnt3a/β-catenin signaling in type 2 diabetic rats
Objective(s): Increasing evidence suggests that regular physical exercise improves type 2 diabetes mellitus (T2DM). However, the potential beneficial effects of swimming on insulin resistance and lipid disorder in T2DM, and its underlying mechanisms remain unclear. Materials and Methods: Rats were f...
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| Format: | Article |
| Language: | English |
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Mashhad University of Medical Sciences
2017-11-01
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| Series: | Iranian Journal of Basic Medical Sciences |
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| Online Access: | http://ijbms.mums.ac.ir/article_9473_bde01bb94ca46a830cc593ec086dd912.pdf |
| _version_ | 1818753361605820416 |
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| author | Qiang Yang Wen-wen Wang Pu Ma Zhong-xuan Ma Meng Hao Temitope I Adelusi Lei Du Xiao-Xing Yin Qian Lu |
| author_facet | Qiang Yang Wen-wen Wang Pu Ma Zhong-xuan Ma Meng Hao Temitope I Adelusi Lei Du Xiao-Xing Yin Qian Lu |
| author_sort | Qiang Yang |
| collection | DOAJ |
| description | Objective(s): Increasing evidence suggests that regular physical exercise improves type 2 diabetes mellitus (T2DM). However, the potential beneficial effects of swimming on insulin resistance and lipid disorder in T2DM, and its underlying mechanisms remain unclear. Materials and Methods: Rats were fed with high fat diet and given a low dosage of Streptozotocin (STZ) to induce T2DM model, and subsequently treated with or without swimming exercise. An 8-week swimming program (30, 60 or 120 min per day, 5 days per week) decreased body weight, fasting blood glucose and fasting insulin. Results: Swimming ameliorated lipid disorder, improved muscular atrophy and revealed a reduced glycogen deposit in skeletal muscles of diabetic rats. Furthermore, swimming also inhibited the activation of Wnt3a/β-catenin signaling pathway, decreased Wnt3a mRNA and protein level, upregulated GSK3β phosphorylation activity and reduced the expression of β-catenin phosphorylation in diabetic rats. Conclusion: The trend of the result suggests that swimming exercise proved to be a potent ameliorator of insulin resistancein T2DM through the modulation of Wnt3a/β-catenin pathway and therefore, could present a promising therapeutic measure towards the treatment of diabetes and its relatives. |
| first_indexed | 2024-12-18T05:06:08Z |
| format | Article |
| id | doaj.art-029e1402ca06485d94244e4d56f7255b |
| institution | Directory Open Access Journal |
| issn | 2008-3866 2008-3874 |
| language | English |
| last_indexed | 2024-12-18T05:06:08Z |
| publishDate | 2017-11-01 |
| publisher | Mashhad University of Medical Sciences |
| record_format | Article |
| series | Iranian Journal of Basic Medical Sciences |
| spelling | doaj.art-029e1402ca06485d94244e4d56f7255b2022-12-21T21:20:00ZengMashhad University of Medical SciencesIranian Journal of Basic Medical Sciences2008-38662008-38742017-11-0120111220122610.22038/ijbms.2017.94739473Swimming training alleviated insulin resistance through Wnt3a/β-catenin signaling in type 2 diabetic ratsQiang Yang0Wen-wen Wang1Pu Ma2Zhong-xuan Ma3Meng Hao4Temitope I Adelusi5Lei Du6Xiao-Xing Yin7Qian Lu8Jiangsu Key Laboratory of New Drug Research and Clinical Pharmacy, Xuzhou 221002, Jiangsu, ChinaJiangsu Key Laboratory of New Drug Research and Clinical Pharmacy, Xuzhou 221002, Jiangsu, ChinaJiangsu Key Laboratory of New Drug Research and Clinical Pharmacy, Xuzhou 221002, Jiangsu, ChinaJiangsu Key Laboratory of New Drug Research and Clinical Pharmacy, Xuzhou 221002, Jiangsu, ChinaJiangsu Key Laboratory of New Drug Research and Clinical Pharmacy, Xuzhou 221002, Jiangsu, ChinaJiangsu Key Laboratory of New Drug Research and Clinical Pharmacy, Xuzhou 221002, Jiangsu, ChinaJiangsu Key Laboratory of New Drug Research and Clinical Pharmacy, Xuzhou 221002, Jiangsu, ChinaJiangsu Key Laboratory of New Drug Research and Clinical Pharmacy, Xuzhou 221002, Jiangsu, ChinaJiangsu Key Laboratory of New Drug Research and Clinical Pharmacy, Xuzhou 221002, Jiangsu, ChinaObjective(s): Increasing evidence suggests that regular physical exercise improves type 2 diabetes mellitus (T2DM). However, the potential beneficial effects of swimming on insulin resistance and lipid disorder in T2DM, and its underlying mechanisms remain unclear. Materials and Methods: Rats were fed with high fat diet and given a low dosage of Streptozotocin (STZ) to induce T2DM model, and subsequently treated with or without swimming exercise. An 8-week swimming program (30, 60 or 120 min per day, 5 days per week) decreased body weight, fasting blood glucose and fasting insulin. Results: Swimming ameliorated lipid disorder, improved muscular atrophy and revealed a reduced glycogen deposit in skeletal muscles of diabetic rats. Furthermore, swimming also inhibited the activation of Wnt3a/β-catenin signaling pathway, decreased Wnt3a mRNA and protein level, upregulated GSK3β phosphorylation activity and reduced the expression of β-catenin phosphorylation in diabetic rats. Conclusion: The trend of the result suggests that swimming exercise proved to be a potent ameliorator of insulin resistancein T2DM through the modulation of Wnt3a/β-catenin pathway and therefore, could present a promising therapeutic measure towards the treatment of diabetes and its relatives.http://ijbms.mums.ac.ir/article_9473_bde01bb94ca46a830cc593ec086dd912.pdfGSK3βInsulin resistanceSwimming trainingType 2 diabetes mellitusWnt3a/β-catenin signaling |
| spellingShingle | Qiang Yang Wen-wen Wang Pu Ma Zhong-xuan Ma Meng Hao Temitope I Adelusi Lei Du Xiao-Xing Yin Qian Lu Swimming training alleviated insulin resistance through Wnt3a/β-catenin signaling in type 2 diabetic rats Iranian Journal of Basic Medical Sciences GSK3β Insulin resistance Swimming training Type 2 diabetes mellitus Wnt3a/β-catenin signaling |
| title | Swimming training alleviated insulin resistance through Wnt3a/β-catenin signaling in type 2 diabetic rats |
| title_full | Swimming training alleviated insulin resistance through Wnt3a/β-catenin signaling in type 2 diabetic rats |
| title_fullStr | Swimming training alleviated insulin resistance through Wnt3a/β-catenin signaling in type 2 diabetic rats |
| title_full_unstemmed | Swimming training alleviated insulin resistance through Wnt3a/β-catenin signaling in type 2 diabetic rats |
| title_short | Swimming training alleviated insulin resistance through Wnt3a/β-catenin signaling in type 2 diabetic rats |
| title_sort | swimming training alleviated insulin resistance through wnt3a β catenin signaling in type 2 diabetic rats |
| topic | GSK3β Insulin resistance Swimming training Type 2 diabetes mellitus Wnt3a/β-catenin signaling |
| url | http://ijbms.mums.ac.ir/article_9473_bde01bb94ca46a830cc593ec086dd912.pdf |
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