Prognostic value of a decrease in mean platelet volume, platelet distribution width, and platelet-large cell ratio for major adverse cardiovascular events after myocardial infarction without ST-segment elevation: An observational study
The current study aimed to explore whether the level of decrease in platelet distribution width (PDW), platelet-large cell ratio (P-LCR), and mean platelet volume (MPV) has prognostic value for major adverse cardiovascular events (MACEs) in acute myocardial infarction without ST-segment elevation (N...
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| Format: | Article |
| Language: | English |
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Association of Basic Medical Sciences of Federation of Bosnia and Herzegovina
2023-09-01
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| Series: | Biomolecules & Biomedicine |
| Subjects: | |
| Online Access: | https://www.bjbms.org/ojs/index.php/bjbms/article/view/9178 |
| _version_ | 1827317489025941504 |
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| author | Emir Bećirović Kenana Ljuca Minela Bećirović Nadina Ljuca Mugdim Bajrić Ammar Brkić Farid Ljuca |
| author_facet | Emir Bećirović Kenana Ljuca Minela Bećirović Nadina Ljuca Mugdim Bajrić Ammar Brkić Farid Ljuca |
| author_sort | Emir Bećirović |
| collection | DOAJ |
| description | The current study aimed to explore whether the level of decrease in platelet distribution width (PDW), platelet-large cell ratio (P-LCR), and mean platelet volume (MPV) has prognostic value for major adverse cardiovascular events (MACEs) in acute myocardial infarction without ST-segment elevation (NSTEMI) treated with clopidogrel. In this prospective observational cohort study, PDW, P-LCR, and MPV were determined on admission at the hospital and 24 h after clopidogrel treatment in 170 non-STEMI patients. MACEs were assessed over a one-year follow-up period. Using the Cox regression test, a decrease in PDW showed a significant association with the incidence of MACEs (odds ratio [OR] 0.82, 95% confidence interval [CI] 0.66–0.99, p = 0.049) and overall survival rate (OR 0.95, 95% CI = 0.91–0.99, p = 0.016). Patients with a decrease in PDW<9.9% had a higher incidence of MACEs (OR 0.42, 95% CI = 0.24–0.72, p = 0.002) and a lower survival rate (OR 0.32, 95% CI = 0.12–0.90, p = 0.03) than patients who had a decrease in PDW < 9.9%. In the Kaplan–Meier analysis using log-rank test, patients who had a decrease in PDW < 9.9% had an increased risk for MACEs (p = 0.002) and lethal outcomes (p = 0.002). However, a decrease in MPV or P-LCR did not have prognostic value. A decrease in PDW < 9.9% measured 24 h after clopidogrel treatment in NSTEMI patients has good prognostic value for determining the short-term risks of MACEs, possibly providing a better risk stratification of those patients.
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| first_indexed | 2024-04-24T23:39:42Z |
| format | Article |
| id | doaj.art-029e820551734611b68e4210e453153d |
| institution | Directory Open Access Journal |
| issn | 2831-0896 2831-090X |
| language | English |
| last_indexed | 2024-04-24T23:39:42Z |
| publishDate | 2023-09-01 |
| publisher | Association of Basic Medical Sciences of Federation of Bosnia and Herzegovina |
| record_format | Article |
| series | Biomolecules & Biomedicine |
| spelling | doaj.art-029e820551734611b68e4210e453153d2024-03-15T13:22:24ZengAssociation of Basic Medical Sciences of Federation of Bosnia and HerzegovinaBiomolecules & Biomedicine2831-08962831-090X2023-09-0123510.17305/bb.2023.9178Prognostic value of a decrease in mean platelet volume, platelet distribution width, and platelet-large cell ratio for major adverse cardiovascular events after myocardial infarction without ST-segment elevation: An observational studyEmir Bećirović0https://orcid.org/0000-0002-4134-987XKenana Ljuca1https://orcid.org/0009-0004-9478-3284Minela Bećirović2https://orcid.org/0009-0007-4391-5226Nadina Ljuca3Mugdim Bajrić4Ammar Brkić5https://orcid.org/0000-0002-5436-3670Farid Ljuca6https://orcid.org/0000-0003-1143-1941Internal Medicine Clinic, University Clinical Center Tuzla, Tuzla, Bosnia and HerzegovinaSchool of Medicine, University of Tuzla, Tuzla, Bosnia and Herzegovina; Health Center of Sarajevo Canton, Sarajevo, Bosnia and HerzegovinaInternal Medicine Clinic, University Clinical Center Tuzla, Tuzla, Bosnia and HerzegovinaSchool of Medicine, University of Tuzla, Tuzla, Bosnia and HerzegovinaDepartment of Cardiovascular Surgery, University Clinical Center Tuzla, Tuzla, Bosnia and HerzegovinaInternal Medicine Clinic, University Clinical Center Tuzla, Tuzla, Bosnia and HerzegovinaDepartment of Physiology, School of Medicine, University of Tuzla, Tuzla, Bosnia and HerzegovinaThe current study aimed to explore whether the level of decrease in platelet distribution width (PDW), platelet-large cell ratio (P-LCR), and mean platelet volume (MPV) has prognostic value for major adverse cardiovascular events (MACEs) in acute myocardial infarction without ST-segment elevation (NSTEMI) treated with clopidogrel. In this prospective observational cohort study, PDW, P-LCR, and MPV were determined on admission at the hospital and 24 h after clopidogrel treatment in 170 non-STEMI patients. MACEs were assessed over a one-year follow-up period. Using the Cox regression test, a decrease in PDW showed a significant association with the incidence of MACEs (odds ratio [OR] 0.82, 95% confidence interval [CI] 0.66–0.99, p = 0.049) and overall survival rate (OR 0.95, 95% CI = 0.91–0.99, p = 0.016). Patients with a decrease in PDW<9.9% had a higher incidence of MACEs (OR 0.42, 95% CI = 0.24–0.72, p = 0.002) and a lower survival rate (OR 0.32, 95% CI = 0.12–0.90, p = 0.03) than patients who had a decrease in PDW < 9.9%. In the Kaplan–Meier analysis using log-rank test, patients who had a decrease in PDW < 9.9% had an increased risk for MACEs (p = 0.002) and lethal outcomes (p = 0.002). However, a decrease in MPV or P-LCR did not have prognostic value. A decrease in PDW < 9.9% measured 24 h after clopidogrel treatment in NSTEMI patients has good prognostic value for determining the short-term risks of MACEs, possibly providing a better risk stratification of those patients. https://www.bjbms.org/ojs/index.php/bjbms/article/view/9178Mean platelet volume (MPV)platelet distribution width (PDW)platelet-large cell ratio (P-LCR)major adverse cardiovascular events (MACE)myocardial infarction without ST-segment elevation |
| spellingShingle | Emir Bećirović Kenana Ljuca Minela Bećirović Nadina Ljuca Mugdim Bajrić Ammar Brkić Farid Ljuca Prognostic value of a decrease in mean platelet volume, platelet distribution width, and platelet-large cell ratio for major adverse cardiovascular events after myocardial infarction without ST-segment elevation: An observational study Biomolecules & Biomedicine Mean platelet volume (MPV) platelet distribution width (PDW) platelet-large cell ratio (P-LCR) major adverse cardiovascular events (MACE) myocardial infarction without ST-segment elevation |
| title | Prognostic value of a decrease in mean platelet volume, platelet distribution width, and platelet-large cell ratio for major adverse cardiovascular events after myocardial infarction without ST-segment elevation: An observational study |
| title_full | Prognostic value of a decrease in mean platelet volume, platelet distribution width, and platelet-large cell ratio for major adverse cardiovascular events after myocardial infarction without ST-segment elevation: An observational study |
| title_fullStr | Prognostic value of a decrease in mean platelet volume, platelet distribution width, and platelet-large cell ratio for major adverse cardiovascular events after myocardial infarction without ST-segment elevation: An observational study |
| title_full_unstemmed | Prognostic value of a decrease in mean platelet volume, platelet distribution width, and platelet-large cell ratio for major adverse cardiovascular events after myocardial infarction without ST-segment elevation: An observational study |
| title_short | Prognostic value of a decrease in mean platelet volume, platelet distribution width, and platelet-large cell ratio for major adverse cardiovascular events after myocardial infarction without ST-segment elevation: An observational study |
| title_sort | prognostic value of a decrease in mean platelet volume platelet distribution width and platelet large cell ratio for major adverse cardiovascular events after myocardial infarction without st segment elevation an observational study |
| topic | Mean platelet volume (MPV) platelet distribution width (PDW) platelet-large cell ratio (P-LCR) major adverse cardiovascular events (MACE) myocardial infarction without ST-segment elevation |
| url | https://www.bjbms.org/ojs/index.php/bjbms/article/view/9178 |
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