The Opioid System in Rainbow Trout Telencephalon Is Probably Involved in the Hedonic Regulation of Food Intake
We hypothesize that opioids are involved in the regulation of food intake in fish through homeostatic and hedonic mechanisms. Therefore, we evaluated in rainbow trout (Oncorhynchus mykiss) hypothalamus and telencephalon changes in precursors, endogenous ligands and receptors of the opioid system und...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-03-01
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| Series: | Frontiers in Physiology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fphys.2022.800218/full |
| _version_ | 1818982162739757056 |
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| author | Adrián Díaz-Rúa Mauro Chivite Sara Comesaña Marta Conde-Sieira José L. Soengas |
| author_facet | Adrián Díaz-Rúa Mauro Chivite Sara Comesaña Marta Conde-Sieira José L. Soengas |
| author_sort | Adrián Díaz-Rúa |
| collection | DOAJ |
| description | We hypothesize that opioids are involved in the regulation of food intake in fish through homeostatic and hedonic mechanisms. Therefore, we evaluated in rainbow trout (Oncorhynchus mykiss) hypothalamus and telencephalon changes in precursors, endogenous ligands and receptors of the opioid system under different situations aimed to induce changes in the homeostatic (through fasted/fed/refed fish) and hedonic (through feeding fish a control or a palatable high-fat diet) regulation of food intake. No major changes occurred in parameters assessed related with the nutritional condition of fish (fasted/fed/refed), allowing us to suggest that the opioid system seems not to have an important role in the homeostatic regulation of food intake in rainbow trout. The responses observed in telencephalon of rainbow trout fed the palatable high-fat diet included a decrease in mRNA abundance of the opioid precursor penka, in a way similar to that known in mammals, and increased mRNA abundance of the opioid receptors oprd1 and oprk1 supporting a role for telencephalic opioid system in the hedonic regulation of food intake in fish. |
| first_indexed | 2024-12-20T17:42:50Z |
| format | Article |
| id | doaj.art-029fc14698ea4562b55179c41c90f6ce |
| institution | Directory Open Access Journal |
| issn | 1664-042X |
| language | English |
| last_indexed | 2024-12-20T17:42:50Z |
| publishDate | 2022-03-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Physiology |
| spelling | doaj.art-029fc14698ea4562b55179c41c90f6ce2022-12-21T19:31:03ZengFrontiers Media S.A.Frontiers in Physiology1664-042X2022-03-011310.3389/fphys.2022.800218800218The Opioid System in Rainbow Trout Telencephalon Is Probably Involved in the Hedonic Regulation of Food IntakeAdrián Díaz-RúaMauro ChiviteSara ComesañaMarta Conde-SieiraJosé L. SoengasWe hypothesize that opioids are involved in the regulation of food intake in fish through homeostatic and hedonic mechanisms. Therefore, we evaluated in rainbow trout (Oncorhynchus mykiss) hypothalamus and telencephalon changes in precursors, endogenous ligands and receptors of the opioid system under different situations aimed to induce changes in the homeostatic (through fasted/fed/refed fish) and hedonic (through feeding fish a control or a palatable high-fat diet) regulation of food intake. No major changes occurred in parameters assessed related with the nutritional condition of fish (fasted/fed/refed), allowing us to suggest that the opioid system seems not to have an important role in the homeostatic regulation of food intake in rainbow trout. The responses observed in telencephalon of rainbow trout fed the palatable high-fat diet included a decrease in mRNA abundance of the opioid precursor penka, in a way similar to that known in mammals, and increased mRNA abundance of the opioid receptors oprd1 and oprk1 supporting a role for telencephalic opioid system in the hedonic regulation of food intake in fish.https://www.frontiersin.org/articles/10.3389/fphys.2022.800218/fullopioidfood intakebrainpalatable dietnutritional condition |
| spellingShingle | Adrián Díaz-Rúa Mauro Chivite Sara Comesaña Marta Conde-Sieira José L. Soengas The Opioid System in Rainbow Trout Telencephalon Is Probably Involved in the Hedonic Regulation of Food Intake Frontiers in Physiology opioid food intake brain palatable diet nutritional condition |
| title | The Opioid System in Rainbow Trout Telencephalon Is Probably Involved in the Hedonic Regulation of Food Intake |
| title_full | The Opioid System in Rainbow Trout Telencephalon Is Probably Involved in the Hedonic Regulation of Food Intake |
| title_fullStr | The Opioid System in Rainbow Trout Telencephalon Is Probably Involved in the Hedonic Regulation of Food Intake |
| title_full_unstemmed | The Opioid System in Rainbow Trout Telencephalon Is Probably Involved in the Hedonic Regulation of Food Intake |
| title_short | The Opioid System in Rainbow Trout Telencephalon Is Probably Involved in the Hedonic Regulation of Food Intake |
| title_sort | opioid system in rainbow trout telencephalon is probably involved in the hedonic regulation of food intake |
| topic | opioid food intake brain palatable diet nutritional condition |
| url | https://www.frontiersin.org/articles/10.3389/fphys.2022.800218/full |
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