Microbial communities of the upper respiratory tract in mild and severe COVID-19 patients: a possible link with the disease course
The microbiota of the respiratory tract remains a relatively poorly studied subject. At the same time, it is involved in modulating the immune response to infectious agents in the host organism, just like the intestinal microbiota. A relationship between the composition of the respiratory microbiota...
| Main Authors: | , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-05-01
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| Series: | Frontiers in Microbiomes |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/frmbi.2023.1067019/full |
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| author | Julia S. Galeeva Elizaveta V. Starikova Dmitry E. Fedorov Alexander I. Manolov Alexander V. Pavlenko Dmitry N. Konanov Danil V. Krivonos Vladislav V. Babenko Ksenia M. Klimina Vladimir A. Veselovsky Maxim D. Morozov Ilshat R. Gafurov Raushaniya F. Gaifullina Vadim M. Govorun Elena N. Ilina |
| author_facet | Julia S. Galeeva Elizaveta V. Starikova Dmitry E. Fedorov Alexander I. Manolov Alexander V. Pavlenko Dmitry N. Konanov Danil V. Krivonos Vladislav V. Babenko Ksenia M. Klimina Vladimir A. Veselovsky Maxim D. Morozov Ilshat R. Gafurov Raushaniya F. Gaifullina Vadim M. Govorun Elena N. Ilina |
| author_sort | Julia S. Galeeva |
| collection | DOAJ |
| description | The microbiota of the respiratory tract remains a relatively poorly studied subject. At the same time, it is involved in modulating the immune response to infectious agents in the host organism, just like the intestinal microbiota. A relationship between the composition of the respiratory microbiota and the likelihood of development and the severity of COVID-19 may be assumed. In this study, we applied the 16S rRNA metagenomic sequencing to analyze the oropharyngeal swabs from 120 COVID-19 patients collected during the first and the second waves of the COVID-19 epidemic in Russia. Differential abundance analysis with respect to comorbidities suggested association of Neisseria oralis, Neisseria mucosa, unidentified Veillonella spp., Lautropia mirabilis species with more severe lung damage, and Streptococcus salivarius, Capnocytophaga sputigena and Haemophilus parahaemolyticus with a milder course of the disease. We hypothesize that the latter bacteria (or some of them) might be beneficial for the respiratory tract and might be able to alleviate the course of the COVID-19 disease. |
| first_indexed | 2024-03-13T08:53:52Z |
| format | Article |
| id | doaj.art-02a122aa1cbe4c30a9927c0a18a9c3c3 |
| institution | Directory Open Access Journal |
| issn | 2813-4338 |
| language | English |
| last_indexed | 2024-03-13T08:53:52Z |
| publishDate | 2023-05-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Microbiomes |
| spelling | doaj.art-02a122aa1cbe4c30a9927c0a18a9c3c32023-05-29T04:17:36ZengFrontiers Media S.A.Frontiers in Microbiomes2813-43382023-05-01210.3389/frmbi.2023.10670191067019Microbial communities of the upper respiratory tract in mild and severe COVID-19 patients: a possible link with the disease courseJulia S. Galeeva0Elizaveta V. Starikova1Dmitry E. Fedorov2Alexander I. Manolov3Alexander V. Pavlenko4Dmitry N. Konanov5Danil V. Krivonos6Vladislav V. Babenko7Ksenia M. Klimina8Vladimir A. Veselovsky9Maxim D. Morozov10Ilshat R. Gafurov11Raushaniya F. Gaifullina12Vadim M. Govorun13Elena N. Ilina14Research Institute for Systems Biology and Medicine, Department of Mathematical Biology and Bioinformatics, Moscow, RussiaResearch Institute for Systems Biology and Medicine, Department of Mathematical Biology and Bioinformatics, Moscow, RussiaResearch Institute for Systems Biology and Medicine, Department of Mathematical Biology and Bioinformatics, Moscow, RussiaResearch Institute for Systems Biology and Medicine, Department of Mathematical Biology and Bioinformatics, Moscow, RussiaResearch Institute for Systems Biology and Medicine, Department of Mathematical Biology and Bioinformatics, Moscow, RussiaResearch Institute for Systems Biology and Medicine, Department of Mathematical Biology and Bioinformatics, Moscow, RussiaResearch Institute for Systems Biology and Medicine, Department of Mathematical Biology and Bioinformatics, Moscow, RussiaLopukhin Federal Research and Clinical Center of Physical-Chemical Medicine of Federal Medical Biological Agency, Department of Molecular Genetics of Microorganisms, Moscow, RussiaLopukhin Federal Research and Clinical Center of Physical-Chemical Medicine of Federal Medical Biological Agency, Department of Molecular Genetics of Microorganisms, Moscow, RussiaLopukhin Federal Research and Clinical Center of Physical-Chemical Medicine of Federal Medical Biological Agency, Department of Molecular Genetics of Microorganisms, Moscow, RussiaLopukhin Federal Research and Clinical Center of Physical-Chemical Medicine of Federal Medical Biological Agency, Department of Molecular Genetics of Microorganisms, Moscow, RussiaKazan Federal University, Department of Molecular Medicine and Biology, Kazan, RussiaKazan Federal University, Department of Molecular Medicine and Biology, Kazan, RussiaResearch Institute for Systems Biology and Medicine, Department of Mathematical Biology and Bioinformatics, Moscow, RussiaResearch Institute for Systems Biology and Medicine, Department of Mathematical Biology and Bioinformatics, Moscow, RussiaThe microbiota of the respiratory tract remains a relatively poorly studied subject. At the same time, it is involved in modulating the immune response to infectious agents in the host organism, just like the intestinal microbiota. A relationship between the composition of the respiratory microbiota and the likelihood of development and the severity of COVID-19 may be assumed. In this study, we applied the 16S rRNA metagenomic sequencing to analyze the oropharyngeal swabs from 120 COVID-19 patients collected during the first and the second waves of the COVID-19 epidemic in Russia. Differential abundance analysis with respect to comorbidities suggested association of Neisseria oralis, Neisseria mucosa, unidentified Veillonella spp., Lautropia mirabilis species with more severe lung damage, and Streptococcus salivarius, Capnocytophaga sputigena and Haemophilus parahaemolyticus with a milder course of the disease. We hypothesize that the latter bacteria (or some of them) might be beneficial for the respiratory tract and might be able to alleviate the course of the COVID-19 disease.https://www.frontiersin.org/articles/10.3389/frmbi.2023.1067019/fullCOVID-1916Shuman microbiomeoropharyngeal swabsSARS-CoV-2upper respiratory tract |
| spellingShingle | Julia S. Galeeva Elizaveta V. Starikova Dmitry E. Fedorov Alexander I. Manolov Alexander V. Pavlenko Dmitry N. Konanov Danil V. Krivonos Vladislav V. Babenko Ksenia M. Klimina Vladimir A. Veselovsky Maxim D. Morozov Ilshat R. Gafurov Raushaniya F. Gaifullina Vadim M. Govorun Elena N. Ilina Microbial communities of the upper respiratory tract in mild and severe COVID-19 patients: a possible link with the disease course Frontiers in Microbiomes COVID-19 16S human microbiome oropharyngeal swabs SARS-CoV-2 upper respiratory tract |
| title | Microbial communities of the upper respiratory tract in mild and severe COVID-19 patients: a possible link with the disease course |
| title_full | Microbial communities of the upper respiratory tract in mild and severe COVID-19 patients: a possible link with the disease course |
| title_fullStr | Microbial communities of the upper respiratory tract in mild and severe COVID-19 patients: a possible link with the disease course |
| title_full_unstemmed | Microbial communities of the upper respiratory tract in mild and severe COVID-19 patients: a possible link with the disease course |
| title_short | Microbial communities of the upper respiratory tract in mild and severe COVID-19 patients: a possible link with the disease course |
| title_sort | microbial communities of the upper respiratory tract in mild and severe covid 19 patients a possible link with the disease course |
| topic | COVID-19 16S human microbiome oropharyngeal swabs SARS-CoV-2 upper respiratory tract |
| url | https://www.frontiersin.org/articles/10.3389/frmbi.2023.1067019/full |
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