Multiple Myeloma (Part 1) - Update on Epidemiology, Diagnostic Criteria, Systemic Treatment and Prognosis
Abstract Multiple myeloma (MM) is a hematological malignancy characterized by unregulated and clonal proliferation of plasma cells in the bone marrow; these cells produce and secrete an anomalous monoclonal immunoglobulin, or a fragment of this, called M protein. The clinical manifestations of MM re...
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| Format: | Article |
| Language: | English |
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Thieme Revinter Publicações Ltda.
2023-07-01
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| Series: | Revista Brasileira de Ortopedia |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0102-36162023000300361&lng=en&tlng=en |
| _version_ | 1797225184850083840 |
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| author | Alex Guedes Ricardo Gehrke Becker Luiz Eduardo Moreira Teixeira |
| author_facet | Alex Guedes Ricardo Gehrke Becker Luiz Eduardo Moreira Teixeira |
| author_sort | Alex Guedes |
| collection | DOAJ |
| description | Abstract Multiple myeloma (MM) is a hematological malignancy characterized by unregulated and clonal proliferation of plasma cells in the bone marrow; these cells produce and secrete an anomalous monoclonal immunoglobulin, or a fragment of this, called M protein. The clinical manifestations of MM result from the proliferation of these plasmocytes, the excessive production of monoclonal immunoglobulin and the suppression of normal humoral immunity, leading to hypercalcemia, bone destruction, renal failure, suppression of hematopoiesis and humoral immunity, increasing the risk for the development of infections. The increase in life expectancy of the world population led to a concomitant increase in the prevalence of MM, a pathology that usually affects the elderly population. The aim of this review is to update the reader on epidemiology, diagnostic criteria, differential diagnosis with other monoclonal gam-mopathies, systemic treatment and prognosis of MM. |
| first_indexed | 2024-03-08T06:49:43Z |
| format | Article |
| id | doaj.art-02a1f525d3174ecfbcd7ca9cd1ab1e32 |
| institution | Directory Open Access Journal |
| issn | 1982-4378 |
| language | English |
| last_indexed | 2024-04-24T14:04:59Z |
| publishDate | 2023-07-01 |
| publisher | Thieme Revinter Publicações Ltda. |
| record_format | Article |
| series | Revista Brasileira de Ortopedia |
| spelling | doaj.art-02a1f525d3174ecfbcd7ca9cd1ab1e322024-04-03T10:36:15ZengThieme Revinter Publicações Ltda.Revista Brasileira de Ortopedia1982-43782023-07-0158336136710.1055/s-0043-1770149Multiple Myeloma (Part 1) - Update on Epidemiology, Diagnostic Criteria, Systemic Treatment and PrognosisAlex Guedeshttps://orcid.org/0000-0001-7013-7107Ricardo Gehrke Beckerhttps://orcid.org/0000-0003-2629-9752Luiz Eduardo Moreira Teixeirahttps://orcid.org/0000-0003-1276-5679Abstract Multiple myeloma (MM) is a hematological malignancy characterized by unregulated and clonal proliferation of plasma cells in the bone marrow; these cells produce and secrete an anomalous monoclonal immunoglobulin, or a fragment of this, called M protein. The clinical manifestations of MM result from the proliferation of these plasmocytes, the excessive production of monoclonal immunoglobulin and the suppression of normal humoral immunity, leading to hypercalcemia, bone destruction, renal failure, suppression of hematopoiesis and humoral immunity, increasing the risk for the development of infections. The increase in life expectancy of the world population led to a concomitant increase in the prevalence of MM, a pathology that usually affects the elderly population. The aim of this review is to update the reader on epidemiology, diagnostic criteria, differential diagnosis with other monoclonal gam-mopathies, systemic treatment and prognosis of MM.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0102-36162023000300361&lng=en&tlng=enepidemiologymonoclonal gammopathy of undetermined significancemultiple myelomasmoldering multiple myelomaplasmacytomaprognosis |
| spellingShingle | Alex Guedes Ricardo Gehrke Becker Luiz Eduardo Moreira Teixeira Multiple Myeloma (Part 1) - Update on Epidemiology, Diagnostic Criteria, Systemic Treatment and Prognosis Revista Brasileira de Ortopedia epidemiology monoclonal gammopathy of undetermined significance multiple myeloma smoldering multiple myeloma plasmacytoma prognosis |
| title | Multiple Myeloma (Part 1) - Update on Epidemiology, Diagnostic Criteria, Systemic Treatment and Prognosis |
| title_full | Multiple Myeloma (Part 1) - Update on Epidemiology, Diagnostic Criteria, Systemic Treatment and Prognosis |
| title_fullStr | Multiple Myeloma (Part 1) - Update on Epidemiology, Diagnostic Criteria, Systemic Treatment and Prognosis |
| title_full_unstemmed | Multiple Myeloma (Part 1) - Update on Epidemiology, Diagnostic Criteria, Systemic Treatment and Prognosis |
| title_short | Multiple Myeloma (Part 1) - Update on Epidemiology, Diagnostic Criteria, Systemic Treatment and Prognosis |
| title_sort | multiple myeloma part 1 update on epidemiology diagnostic criteria systemic treatment and prognosis |
| topic | epidemiology monoclonal gammopathy of undetermined significance multiple myeloma smoldering multiple myeloma plasmacytoma prognosis |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0102-36162023000300361&lng=en&tlng=en |
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