Inhibition of Myostatin Reduces Collagen Deposition in a Mouse Model of Oculopharyngeal Muscular Dystrophy (OPMD) With Established Disease

Inhibition of Myostatin Reduces Collagen Deposition in a Mouse Model of Oculopharyngeal Muscular Dystrophy (OPMD) With Established Disease

BackgroundOculopharyngeal muscular dystrophy (OPMD) is a late-onset muscle disease presented by ptosis, dysphagia, and limb weakness. Affected muscles display increased fibrosis and atrophy, with characteristic inclusion bodies in the nucleus. Myostatin is a negative regulator of muscle mass, and in...

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Bibliographic Details
Main Authors: Pradeep Harish, Leysa Forrest, Shanti Herath, George Dickson, Alberto Malerba, Linda Popplewell
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-03-01
Series:Frontiers in Physiology
Subjects:
OPMD
myostatin
antibody
RK35
muscular dystrophy
Online Access:https://www.frontiersin.org/article/10.3389/fphys.2020.00184/full

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