Loss of UCP1 function augments recruitment of futile lipid cycling for thermogenesis in murine brown fat

Loss of UCP1 function augments recruitment of futile lipid cycling for thermogenesis in murine brown fat

Objective: Classical ATP-independent non-shivering thermogenesis enabled by uncoupling protein 1 (UCP1) in brown adipose tissue (BAT) is activated, but not essential for survival, in the cold. It has long been suspected that futile ATP-consuming substrate cycles also contribute to thermogenesis and...

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Main Authors: Josef Oeckl, Petra Janovska, Katerina Adamcova, Kristina Bardova, Sarah Brunner, Sebastian Dieckmann, Josef Ecker, Tobias Fromme, Jiri Funda, Thomas Gantert, Piero Giansanti, Maria Soledad Hidrobo, Ondrej Kuda, Bernhard Kuster, Yongguo Li, Radek Pohl, Sabine Schmitt, Sabine Schweizer, Hans Zischka, Petr Zouhar, Jan Kopecky, Martin Klingenspor
Format: Article
Language:English
Published: Elsevier 2022-07-01
Series:Molecular Metabolism
Subjects:
Brown adipose tissue
UCP1-independent thermogenesis
Futile substrate cycle
Lipolysis
Re-esterification
Fatty acids
Online Access:http://www.sciencedirect.com/science/article/pii/S2212877822000680

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