Neurosurgical Management of Central Nervous System Lymphoma: Lessons Learnt from a Neuro-Oncology Multidisciplinary Team Approach
Central nervous system lymphoma (CNSL) represents one of the most aggressive forms of extranodal lymphoma. The gold standard for CNSL diagnosis remains the stereotactic biopsy, with a limited role for cytoreductive surgery that has not been supported by historical data. Our study aims to provide a c...
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| Format: | Article |
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MDPI AG
2023-04-01
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| Series: | Journal of Personalized Medicine |
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| Online Access: | https://www.mdpi.com/2075-4426/13/5/783 |
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| author | Maria Alexandra Velicu Jose Pedro Lavrador Naomi Sibtain Francesco Vergani Ranjeev Bhangoo Richard Gullan Keyoumars Ashkan |
| author_facet | Maria Alexandra Velicu Jose Pedro Lavrador Naomi Sibtain Francesco Vergani Ranjeev Bhangoo Richard Gullan Keyoumars Ashkan |
| author_sort | Maria Alexandra Velicu |
| collection | DOAJ |
| description | Central nervous system lymphoma (CNSL) represents one of the most aggressive forms of extranodal lymphoma. The gold standard for CNSL diagnosis remains the stereotactic biopsy, with a limited role for cytoreductive surgery that has not been supported by historical data. Our study aims to provide a comprehensive overview of neurosurgery’s role in the diagnosis of systemic relapsed and primary CNSL, with an emphasis on the impact on management and survival. This is a single center retrospective cohort study with data collected between August 2012 and August 2020, including patients referred with a potential diagnosis of CNSL to the local Neuro-oncology Multidisciplinary Team (MDT). The concordance between the MDT outcome and histopathological confirmation was assessed using diagnostic statistics. A Cox regression is used for overall survival (OS) risk factor analysis, and Kaplan–Meier statistics are performed for three prognostic models. The diagnosis of lymphoma is confirmed in all cases of relapsed CNSL, and in all but two patients who underwent neurosurgery. For the relapsed CNSL group, the highest positive predictive value (PPV) is found for an MDT outcome when lymphoma had been considered as single or topmost probable diagnosis. Neuro-oncology MDT has an important role in establishing the diagnosis in CNSL, not only to plan tissue diagnosis but also to stratify the surgical candidates. The MDT outcome based on history and imaging has good predictive value for cases where lymphoma is considered the most probable diagnosis, with the best prediction for cases of relapsed CNSL, questioning the need for invasive tissue diagnosis in the latter group. |
| first_indexed | 2024-03-11T03:35:03Z |
| format | Article |
| id | doaj.art-02a4a66cfc0a4868b45676bc92a679e5 |
| institution | Directory Open Access Journal |
| issn | 2075-4426 |
| language | English |
| last_indexed | 2024-03-11T03:35:03Z |
| publishDate | 2023-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Personalized Medicine |
| spelling | doaj.art-02a4a66cfc0a4868b45676bc92a679e52023-11-18T02:04:04ZengMDPI AGJournal of Personalized Medicine2075-44262023-04-0113578310.3390/jpm13050783Neurosurgical Management of Central Nervous System Lymphoma: Lessons Learnt from a Neuro-Oncology Multidisciplinary Team ApproachMaria Alexandra Velicu0Jose Pedro Lavrador1Naomi Sibtain2Francesco Vergani3Ranjeev Bhangoo4Richard Gullan5Keyoumars Ashkan6Department of Neurosurgery, King’s College Hospital NHS Foundation Trust, London SE5 9RS, UKDepartment of Neurosurgery, King’s College Hospital NHS Foundation Trust, London SE5 9RS, UKDepartment of Neuroradiology, King’s College Hospital NHS Foundation Trust, London SE5 9RS, UKDepartment of Neurosurgery, King’s College Hospital NHS Foundation Trust, London SE5 9RS, UKDepartment of Neurosurgery, King’s College Hospital NHS Foundation Trust, London SE5 9RS, UKDepartment of Neurosurgery, King’s College Hospital NHS Foundation Trust, London SE5 9RS, UKDepartment of Neurosurgery, King’s College Hospital NHS Foundation Trust, London SE5 9RS, UKCentral nervous system lymphoma (CNSL) represents one of the most aggressive forms of extranodal lymphoma. The gold standard for CNSL diagnosis remains the stereotactic biopsy, with a limited role for cytoreductive surgery that has not been supported by historical data. Our study aims to provide a comprehensive overview of neurosurgery’s role in the diagnosis of systemic relapsed and primary CNSL, with an emphasis on the impact on management and survival. This is a single center retrospective cohort study with data collected between August 2012 and August 2020, including patients referred with a potential diagnosis of CNSL to the local Neuro-oncology Multidisciplinary Team (MDT). The concordance between the MDT outcome and histopathological confirmation was assessed using diagnostic statistics. A Cox regression is used for overall survival (OS) risk factor analysis, and Kaplan–Meier statistics are performed for three prognostic models. The diagnosis of lymphoma is confirmed in all cases of relapsed CNSL, and in all but two patients who underwent neurosurgery. For the relapsed CNSL group, the highest positive predictive value (PPV) is found for an MDT outcome when lymphoma had been considered as single or topmost probable diagnosis. Neuro-oncology MDT has an important role in establishing the diagnosis in CNSL, not only to plan tissue diagnosis but also to stratify the surgical candidates. The MDT outcome based on history and imaging has good predictive value for cases where lymphoma is considered the most probable diagnosis, with the best prediction for cases of relapsed CNSL, questioning the need for invasive tissue diagnosis in the latter group.https://www.mdpi.com/2075-4426/13/5/783CNS lymphomaDLBCLPCNSLlymphoma CNS relapseextranodal lymphoma |
| spellingShingle | Maria Alexandra Velicu Jose Pedro Lavrador Naomi Sibtain Francesco Vergani Ranjeev Bhangoo Richard Gullan Keyoumars Ashkan Neurosurgical Management of Central Nervous System Lymphoma: Lessons Learnt from a Neuro-Oncology Multidisciplinary Team Approach Journal of Personalized Medicine CNS lymphoma DLBCL PCNSL lymphoma CNS relapse extranodal lymphoma |
| title | Neurosurgical Management of Central Nervous System Lymphoma: Lessons Learnt from a Neuro-Oncology Multidisciplinary Team Approach |
| title_full | Neurosurgical Management of Central Nervous System Lymphoma: Lessons Learnt from a Neuro-Oncology Multidisciplinary Team Approach |
| title_fullStr | Neurosurgical Management of Central Nervous System Lymphoma: Lessons Learnt from a Neuro-Oncology Multidisciplinary Team Approach |
| title_full_unstemmed | Neurosurgical Management of Central Nervous System Lymphoma: Lessons Learnt from a Neuro-Oncology Multidisciplinary Team Approach |
| title_short | Neurosurgical Management of Central Nervous System Lymphoma: Lessons Learnt from a Neuro-Oncology Multidisciplinary Team Approach |
| title_sort | neurosurgical management of central nervous system lymphoma lessons learnt from a neuro oncology multidisciplinary team approach |
| topic | CNS lymphoma DLBCL PCNSL lymphoma CNS relapse extranodal lymphoma |
| url | https://www.mdpi.com/2075-4426/13/5/783 |
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