Sensitive and rapid determination of amantadine without derivatization in human plasma by LC–MS/MS for a bioequivalence study

Sensitive and rapid determination of amantadine without derivatization in human plasma by LC–MS/MS for a bioequivalence study

A highly sensitive, rapid and rugged liquid chromatography-tandem mass spectrometry (LC-ESI-MS/MS) method was developed for reliable estimation of amantadine (AMD), an antiviral drug in human plasma. The analyte and internal standard (IS), amantadine-d6 (AMD-d6), were extracted from 200 µL plasma by...

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Bibliographic Details
Main Authors:	Abhaysingh Bhadoriya, Shivprakash Rathnam, Bhavesh Dasandi, Dharmesh Parmar, Mallika Sanyal, Pranav S. Shrivastav
Format:	Article
Language:	English
Published:	Elsevier 2018-06-01
Series:	Journal of Pharmaceutical Analysis
Online Access:	http://www.sciencedirect.com/science/article/pii/S2095177917301156

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