Temporary Right-Ventricular Assist Devices: A Systematic Review
Acute right-sided heart failure (RHF) is a complex clinical syndrome, with a wide range of clinical presentations, associated with increased mortality and morbidity, but about which there is a scarcity of evidence-based literature. A temporary right-ventricular assist device (t-RVAD) is a potential...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-01-01
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| Series: | Journal of Clinical Medicine |
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| Online Access: | https://www.mdpi.com/2077-0383/11/3/613 |
| _version_ | 1797486940650471424 |
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| author | Mahmoud Abdelshafy Kadir Caliskan Goksel Guven Ahmed Elkoumy Hagar Elsherbini Hesham Elzomor Erhan Tenekecioglu Sakir Akin Osama Soliman |
| author_facet | Mahmoud Abdelshafy Kadir Caliskan Goksel Guven Ahmed Elkoumy Hagar Elsherbini Hesham Elzomor Erhan Tenekecioglu Sakir Akin Osama Soliman |
| author_sort | Mahmoud Abdelshafy |
| collection | DOAJ |
| description | Acute right-sided heart failure (RHF) is a complex clinical syndrome, with a wide range of clinical presentations, associated with increased mortality and morbidity, but about which there is a scarcity of evidence-based literature. A temporary right-ventricular assist device (t-RVAD) is a potential treatment option for selected patients with severe right-ventricular dysfunction as a bridge-to-recovery or as a permanent solution. We sought to conduct a systematic review to determine the safety and efficacy of t-RVAD implantation. Thirty-one studies met the inclusion criteria, from which data were extracted. Successful t-RVAD weaning ranged between 23% and 100%. Moreover, 30-day survival post-temporary RAVD implantation ranged from 46% to 100%. Bleeding, acute kidney injury, stroke, and device malfunction were the most commonly reported complications. Notwithstanding this, t-RVAD is a lifesaving option for patients with severe RHF, but the evidence stems from small non-randomized heterogeneous studies utilizing a variety of devices. Both the etiology of RHF and time of intervention might play a major role in determining the t-RVAD outcome. Standardized endpoints definitions, design and methodology for t-RVAD trials is needed. Furthermore, efforts should continue in improving the technology as well as improving the timely provision of a t-RVAD. |
| first_indexed | 2024-03-09T23:41:29Z |
| format | Article |
| id | doaj.art-02a69c8687e24a459347fa37c6d29141 |
| institution | Directory Open Access Journal |
| issn | 2077-0383 |
| language | English |
| last_indexed | 2024-03-09T23:41:29Z |
| publishDate | 2022-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Clinical Medicine |
| spelling | doaj.art-02a69c8687e24a459347fa37c6d291412023-11-23T16:51:15ZengMDPI AGJournal of Clinical Medicine2077-03832022-01-0111361310.3390/jcm11030613Temporary Right-Ventricular Assist Devices: A Systematic ReviewMahmoud Abdelshafy0Kadir Caliskan1Goksel Guven2Ahmed Elkoumy3Hagar Elsherbini4Hesham Elzomor5Erhan Tenekecioglu6Sakir Akin7Osama Soliman8Discipline of Cardiology, Saolta Group, Galway University Hospital, Health Service Executive and CORRIB Core Lab, National University of Ireland Galway (NUIG), H91 V4AY Galway, IrelandDepartment of Cardiology, Erasmus MC University Medical Center, 3015 GD Rotterdam, The NetherlandsDepartment of Intensive Care Medicine, Erasmus MC University Medical Center, 3015 GD Rotterdam, The NetherlandsDiscipline of Cardiology, Saolta Group, Galway University Hospital, Health Service Executive and CORRIB Core Lab, National University of Ireland Galway (NUIG), H91 V4AY Galway, IrelandDepartment of Cardiology, Erasmus MC University Medical Center, 3015 GD Rotterdam, The NetherlandsDiscipline of Cardiology, Saolta Group, Galway University Hospital, Health Service Executive and CORRIB Core Lab, National University of Ireland Galway (NUIG), H91 V4AY Galway, IrelandDepartment of Cardiology, Erasmus MC University Medical Center, 3015 GD Rotterdam, The NetherlandsDepartment of Cardiology, Erasmus MC University Medical Center, 3015 GD Rotterdam, The NetherlandsDiscipline of Cardiology, Saolta Group, Galway University Hospital, Health Service Executive and CORRIB Core Lab, National University of Ireland Galway (NUIG), H91 V4AY Galway, IrelandAcute right-sided heart failure (RHF) is a complex clinical syndrome, with a wide range of clinical presentations, associated with increased mortality and morbidity, but about which there is a scarcity of evidence-based literature. A temporary right-ventricular assist device (t-RVAD) is a potential treatment option for selected patients with severe right-ventricular dysfunction as a bridge-to-recovery or as a permanent solution. We sought to conduct a systematic review to determine the safety and efficacy of t-RVAD implantation. Thirty-one studies met the inclusion criteria, from which data were extracted. Successful t-RVAD weaning ranged between 23% and 100%. Moreover, 30-day survival post-temporary RAVD implantation ranged from 46% to 100%. Bleeding, acute kidney injury, stroke, and device malfunction were the most commonly reported complications. Notwithstanding this, t-RVAD is a lifesaving option for patients with severe RHF, but the evidence stems from small non-randomized heterogeneous studies utilizing a variety of devices. Both the etiology of RHF and time of intervention might play a major role in determining the t-RVAD outcome. Standardized endpoints definitions, design and methodology for t-RVAD trials is needed. Furthermore, efforts should continue in improving the technology as well as improving the timely provision of a t-RVAD.https://www.mdpi.com/2077-0383/11/3/613right-sided heart failuretemporary right ventricular assist devicesafetyefficacysystematic review |
| spellingShingle | Mahmoud Abdelshafy Kadir Caliskan Goksel Guven Ahmed Elkoumy Hagar Elsherbini Hesham Elzomor Erhan Tenekecioglu Sakir Akin Osama Soliman Temporary Right-Ventricular Assist Devices: A Systematic Review Journal of Clinical Medicine right-sided heart failure temporary right ventricular assist device safety efficacy systematic review |
| title | Temporary Right-Ventricular Assist Devices: A Systematic Review |
| title_full | Temporary Right-Ventricular Assist Devices: A Systematic Review |
| title_fullStr | Temporary Right-Ventricular Assist Devices: A Systematic Review |
| title_full_unstemmed | Temporary Right-Ventricular Assist Devices: A Systematic Review |
| title_short | Temporary Right-Ventricular Assist Devices: A Systematic Review |
| title_sort | temporary right ventricular assist devices a systematic review |
| topic | right-sided heart failure temporary right ventricular assist device safety efficacy systematic review |
| url | https://www.mdpi.com/2077-0383/11/3/613 |
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