Adherence to treatment and anticoagulation control in vitamin K antagonists-treated patients: an administrative databases analysis in a large Italian population
Oral anticoagulant therapy is essential for the treatment and prevention of many thromboembolic disorders. The aim of the present study is to evaluate the level of anticoagulation intensity in patients treated with vitamin K antagonists (VKAs) in a clinical practice setting and to explore the relati...
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| Format: | Article |
| Language: | English |
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SEEd Medical Publishers
2011-06-01
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| Series: | Farmeconomia: Health Economics and Therapeutic Pathways |
| Subjects: | |
| Online Access: | https://journals.seedmedicalpublishers.com/index.php/FE/article/view/71 |
| _version_ | 1811226860537774080 |
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| author | Luca Degli Esposti Diego Sangiorgi Giuseppe Di Pasquale Gian Franco Gensini Ido Iori Stefano Buda Ezio Degli Esposti |
| author_facet | Luca Degli Esposti Diego Sangiorgi Giuseppe Di Pasquale Gian Franco Gensini Ido Iori Stefano Buda Ezio Degli Esposti |
| author_sort | Luca Degli Esposti |
| collection | DOAJ |
| description | Oral anticoagulant therapy is essential for the treatment and prevention of many thromboembolic disorders. The aim of the present study is to evaluate the level of anticoagulation intensity in patients treated with vitamin K antagonists (VKAs) in a clinical practice setting and to explore the relationship between anticoagulation intensity and adherence to VKA treatment. We conducted a retrospective cohort study using the administrative databases of three Italian Local Health Units. Patients were enrolled if they had filled at least one prescription for VKAs (ATC code B01AA) between January 1st, 2007 and June 30th, 2008. In the same period all determinations of the international normalised ratio (INR) were collected. The parameters evaluated were anticoagulation control and adherence to VKA treatment.
The survey showed that only 47.9% and 56.3% of INR determinations, in VKA naïve and established patients respectively, were into the recommended range (2.0-3.0). Moreover, the percentage of INR determination below the recommended range was higher than the percentage of INR determination above the recommended range for both naïve and established patients. Moreover, adherence to VKA treatment was poor both in naïve and established patients and, consequently, anticoagulation control is poor. Also in patients with the highest adherence to VKA treatment, only about 60% of INR determinations were into the recommended range. Our findings evidence that the anticoagulation control in clinical practice settings is still unsatisfactory and it is necessary to evaluate interventions to increase the amount of time at which patients’ INR are within the recommended range. |
| first_indexed | 2024-04-12T09:33:04Z |
| format | Article |
| id | doaj.art-02a6c29dcf3740d8ad05b31f900b89e4 |
| institution | Directory Open Access Journal |
| issn | 2240-256X |
| language | English |
| last_indexed | 2024-04-12T09:33:04Z |
| publishDate | 2011-06-01 |
| publisher | SEEd Medical Publishers |
| record_format | Article |
| series | Farmeconomia: Health Economics and Therapeutic Pathways |
| spelling | doaj.art-02a6c29dcf3740d8ad05b31f900b89e42022-12-22T03:38:19ZengSEEd Medical PublishersFarmeconomia: Health Economics and Therapeutic Pathways2240-256X2011-06-01122535910.7175/fe.v12i2.7162Adherence to treatment and anticoagulation control in vitamin K antagonists-treated patients: an administrative databases analysis in a large Italian populationLuca Degli Esposti0Diego Sangiorgi1Giuseppe Di Pasquale2Gian Franco Gensini3Ido Iori4Stefano Buda5Ezio Degli Esposti6CliCon S.r.l. Health, Economics and Outcomes Research, RavennaCliCon S.r.l. Health, Economics and Outcomes Research, RavennaUnità Operativa di Cardiologia. Ospedale Maggiore, BolognaDipartimento di Area Critica Medico-Chirurgica, Università degli Studi di Firenze, Azienda Ospedaliero-Universitaria, Careggi Fondazione Don Carlo Gnocchi, Onlus IRCCS, Impruneta, FirenzeMedicina Interna I, Centro Emostasi e Trombosi-Stroke Unit, Azienda Ospedaliera A.S.M.N., Reggio EmiliaCliCon S.r.l. Health, Economics and Outcomes Research, RavennaCliCon S.r.l. Health, Economics and Outcomes Research, RavennaOral anticoagulant therapy is essential for the treatment and prevention of many thromboembolic disorders. The aim of the present study is to evaluate the level of anticoagulation intensity in patients treated with vitamin K antagonists (VKAs) in a clinical practice setting and to explore the relationship between anticoagulation intensity and adherence to VKA treatment. We conducted a retrospective cohort study using the administrative databases of three Italian Local Health Units. Patients were enrolled if they had filled at least one prescription for VKAs (ATC code B01AA) between January 1st, 2007 and June 30th, 2008. In the same period all determinations of the international normalised ratio (INR) were collected. The parameters evaluated were anticoagulation control and adherence to VKA treatment. The survey showed that only 47.9% and 56.3% of INR determinations, in VKA naïve and established patients respectively, were into the recommended range (2.0-3.0). Moreover, the percentage of INR determination below the recommended range was higher than the percentage of INR determination above the recommended range for both naïve and established patients. Moreover, adherence to VKA treatment was poor both in naïve and established patients and, consequently, anticoagulation control is poor. Also in patients with the highest adherence to VKA treatment, only about 60% of INR determinations were into the recommended range. Our findings evidence that the anticoagulation control in clinical practice settings is still unsatisfactory and it is necessary to evaluate interventions to increase the amount of time at which patients’ INR are within the recommended range.https://journals.seedmedicalpublishers.com/index.php/FE/article/view/71adherence to treatmentanticoagulation controlinrvitamin k antagonistsadministrative databases |
| spellingShingle | Luca Degli Esposti Diego Sangiorgi Giuseppe Di Pasquale Gian Franco Gensini Ido Iori Stefano Buda Ezio Degli Esposti Adherence to treatment and anticoagulation control in vitamin K antagonists-treated patients: an administrative databases analysis in a large Italian population Farmeconomia: Health Economics and Therapeutic Pathways adherence to treatment anticoagulation control inr vitamin k antagonists administrative databases |
| title | Adherence to treatment and anticoagulation control in vitamin K antagonists-treated patients: an administrative databases analysis in a large Italian population |
| title_full | Adherence to treatment and anticoagulation control in vitamin K antagonists-treated patients: an administrative databases analysis in a large Italian population |
| title_fullStr | Adherence to treatment and anticoagulation control in vitamin K antagonists-treated patients: an administrative databases analysis in a large Italian population |
| title_full_unstemmed | Adherence to treatment and anticoagulation control in vitamin K antagonists-treated patients: an administrative databases analysis in a large Italian population |
| title_short | Adherence to treatment and anticoagulation control in vitamin K antagonists-treated patients: an administrative databases analysis in a large Italian population |
| title_sort | adherence to treatment and anticoagulation control in vitamin k antagonists treated patients an administrative databases analysis in a large italian population |
| topic | adherence to treatment anticoagulation control inr vitamin k antagonists administrative databases |
| url | https://journals.seedmedicalpublishers.com/index.php/FE/article/view/71 |
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