Evaluation of Breast Galactography Using Digital Breast Tomosynthesis: A Clinical Exploratory Study
Objectives: To compare the application value of digital breast tomosynthesis (DBT) and full-field digital mammography (FFDM) in breast galactography. Materials and Methods: A total of 128 patients with pathological nipple discharge (PND) were selected to undergo galactography. DBT and FFDM were perf...
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| Format: | Article |
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MDPI AG
2021-11-01
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| Series: | Diagnostics |
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| Online Access: | https://www.mdpi.com/2075-4418/11/11/2060 |
| _version_ | 1797510628137500672 |
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| author | Juan Tao Hao Liao Yuan Liu Qingsong Peng Wenying Zhu Shuyi Peng Jie Liu Leqing Chen Fan Yang |
| author_facet | Juan Tao Hao Liao Yuan Liu Qingsong Peng Wenying Zhu Shuyi Peng Jie Liu Leqing Chen Fan Yang |
| author_sort | Juan Tao |
| collection | DOAJ |
| description | Objectives: To compare the application value of digital breast tomosynthesis (DBT) and full-field digital mammography (FFDM) in breast galactography. Materials and Methods: A total of 128 patients with pathological nipple discharge (PND) were selected to undergo galactography. DBT and FFDM were performed for each patient after injecting the contrast agent; the radiation dose of DBT and FFDM was calculated, and the image quality was evaluated in consensus by two senior breast radiologists. Histopathologic data were found in 49 of the 128 patients. Sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) for both FFDM- and DBT-galactography were calculated using histopathologic results as a reference standard. Data were presented as percentages along with their 95% confidence intervals (CI). Results: The average age of the 128 patients was 46.53 years. The average glandular dose (AGD) of DBT-galactography was slightly higher than that of FFDM-galactography (<i>p</i> < 0.001). DBT-galactography was 30.7% higher than FFDM-galactography in CC view, while DBT-galactography increased by 21.7% compared with FFDM-galactography in ML view. Regarding catheter anatomic distortion, structure detail, and overall image quality groups, DBT scores were higher than FFDM scores, and the differences were significant for all measures (<i>p</i> < 0.05). In 49 patients with pathological nipple discharge, we found that the DBT-galactography had higher sensitivity, specificity, PPV, and NPV (93.3%, 75%, 97.7%, and 50%, respectively) than FFDM-galactography (91.1%, 50%, 95.3%, and 33.3%, respectively). Conclusions: Compared to FFDM-galactography, within the acceptable radiation dose range, DBT-galactography increases the sensitivity and specificity of lesion detection by improving the image quality, providing more confidence for the diagnosis of clinical ductal lesions. |
| first_indexed | 2024-03-10T05:34:02Z |
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| institution | Directory Open Access Journal |
| issn | 2075-4418 |
| language | English |
| last_indexed | 2024-03-10T05:34:02Z |
| publishDate | 2021-11-01 |
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| record_format | Article |
| series | Diagnostics |
| spelling | doaj.art-02a7e40e65124b10862787fb2b1b6b662023-11-22T23:01:46ZengMDPI AGDiagnostics2075-44182021-11-011111206010.3390/diagnostics11112060Evaluation of Breast Galactography Using Digital Breast Tomosynthesis: A Clinical Exploratory StudyJuan Tao0Hao Liao1Yuan Liu2Qingsong Peng3Wenying Zhu4Shuyi Peng5Jie Liu6Leqing Chen7Fan Yang8Department of Radiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, ChinaDepartment of Radiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, ChinaDepartment of Radiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, ChinaDXR Collaborations, GE Healthcare, Shanghai 201200, ChinaDepartment of Radiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, ChinaDepartment of Radiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, ChinaDepartment of Radiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, ChinaDepartment of Radiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, ChinaDepartment of Radiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, ChinaObjectives: To compare the application value of digital breast tomosynthesis (DBT) and full-field digital mammography (FFDM) in breast galactography. Materials and Methods: A total of 128 patients with pathological nipple discharge (PND) were selected to undergo galactography. DBT and FFDM were performed for each patient after injecting the contrast agent; the radiation dose of DBT and FFDM was calculated, and the image quality was evaluated in consensus by two senior breast radiologists. Histopathologic data were found in 49 of the 128 patients. Sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) for both FFDM- and DBT-galactography were calculated using histopathologic results as a reference standard. Data were presented as percentages along with their 95% confidence intervals (CI). Results: The average age of the 128 patients was 46.53 years. The average glandular dose (AGD) of DBT-galactography was slightly higher than that of FFDM-galactography (<i>p</i> < 0.001). DBT-galactography was 30.7% higher than FFDM-galactography in CC view, while DBT-galactography increased by 21.7% compared with FFDM-galactography in ML view. Regarding catheter anatomic distortion, structure detail, and overall image quality groups, DBT scores were higher than FFDM scores, and the differences were significant for all measures (<i>p</i> < 0.05). In 49 patients with pathological nipple discharge, we found that the DBT-galactography had higher sensitivity, specificity, PPV, and NPV (93.3%, 75%, 97.7%, and 50%, respectively) than FFDM-galactography (91.1%, 50%, 95.3%, and 33.3%, respectively). Conclusions: Compared to FFDM-galactography, within the acceptable radiation dose range, DBT-galactography increases the sensitivity and specificity of lesion detection by improving the image quality, providing more confidence for the diagnosis of clinical ductal lesions.https://www.mdpi.com/2075-4418/11/11/2060digital breast tomosynthesisgalactographypathological nipple dischargefull-field digital mammographyaverage glandular dose |
| spellingShingle | Juan Tao Hao Liao Yuan Liu Qingsong Peng Wenying Zhu Shuyi Peng Jie Liu Leqing Chen Fan Yang Evaluation of Breast Galactography Using Digital Breast Tomosynthesis: A Clinical Exploratory Study Diagnostics digital breast tomosynthesis galactography pathological nipple discharge full-field digital mammography average glandular dose |
| title | Evaluation of Breast Galactography Using Digital Breast Tomosynthesis: A Clinical Exploratory Study |
| title_full | Evaluation of Breast Galactography Using Digital Breast Tomosynthesis: A Clinical Exploratory Study |
| title_fullStr | Evaluation of Breast Galactography Using Digital Breast Tomosynthesis: A Clinical Exploratory Study |
| title_full_unstemmed | Evaluation of Breast Galactography Using Digital Breast Tomosynthesis: A Clinical Exploratory Study |
| title_short | Evaluation of Breast Galactography Using Digital Breast Tomosynthesis: A Clinical Exploratory Study |
| title_sort | evaluation of breast galactography using digital breast tomosynthesis a clinical exploratory study |
| topic | digital breast tomosynthesis galactography pathological nipple discharge full-field digital mammography average glandular dose |
| url | https://www.mdpi.com/2075-4418/11/11/2060 |
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