The impact of respiratory reactance in oscillometry on survival in patients with idiopathic pulmonary fibrosis
Abstract Background Idiopathic pulmonary fibrosis (IPF) is a progressive disease with a poor prognosis. Pulmonary function tests (PFTs) aid in evaluating the disease status of IPF. The clinical significance of oscillometry measurements in interstitial lung diseases has recently been reported. Our pr...
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| Format: | Article |
| Language: | English |
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BMC
2024-01-01
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| Series: | BMC Pulmonary Medicine |
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| Online Access: | https://doi.org/10.1186/s12890-023-02776-y |
| _version_ | 1827388780702597120 |
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| author | Tatsuru Ishikawa Hirotaka Nishikiori Yuki Mori Keiko Fujino Atsushi Saito Mamoru Takahashi Koji Kuronuma Shiro Hinotsu Hirofumi Chiba |
| author_facet | Tatsuru Ishikawa Hirotaka Nishikiori Yuki Mori Keiko Fujino Atsushi Saito Mamoru Takahashi Koji Kuronuma Shiro Hinotsu Hirofumi Chiba |
| author_sort | Tatsuru Ishikawa |
| collection | DOAJ |
| description | Abstract Background Idiopathic pulmonary fibrosis (IPF) is a progressive disease with a poor prognosis. Pulmonary function tests (PFTs) aid in evaluating the disease status of IPF. The clinical significance of oscillometry measurements in interstitial lung diseases has recently been reported. Our previous study showed that respiratory reactance (Xrs) measured by oscillometry reflected disease severity and predicted subsequent lung capacity decline in patients with IPF. However, the direct impact of Xrs on survival needs to be determined, and there are currently no reference values in oscillometry to predict prognosis. Therefore, this study aimed to investigate the association between oscillometry measurements, particularly Xrs, and survival in patients with IPF and to determine the cutoff values of Xrs that predict 3-year survival. Methods We analyzed the relationship between the measured values of PFT and oscillometry derived from 178 patients with IPF. Univariate and multivariate Cox proportional hazards analyses were performed to investigate the relationships between clinical indices at the time of the first oscillometry and survival. We performed the time-dependent receiver operating characteristic (ROC) curve analysis to set the optimized cutoff values of Xrs for 3-year survival prediction. We examined the discriminating power of cutoff values of Xrs on survival using the Kaplan–Meier method and the log-rank test. Results Xrs components, especially in the inspiratory phase (In), significantly correlated with the PFT values. In the multivariate analyses, Xrs (all of reactance at 5 Hz [X5], resonant frequency [Fres], and low-frequency reactance area [ALX] in the inspiratory phase) had a significant impact on survival (X5, p = 0.003; Fres, p = 0.016; ALX, p = 0.003) independent of age, sex, and other prognostic factors derived from the univariate analysis. The area under the ROC curve was 0.765, 0.759, and 0.766 for X5 In, Fres In, and ALX In, with cutoff values determined at − 0.98, 10.67, and 5.32, respectively. We found significant differences in survival after dividing patients using each of the cutoff values of Xrs. Conclusions In patients with IPF, Xrs measured by oscillometry significantly impacted survival. We also determined the cutoff values of Xrs to discriminate patients with poor prognoses. |
| first_indexed | 2024-03-08T16:23:55Z |
| format | Article |
| id | doaj.art-02a9b6267fda44a782cee53fcbb5f3fc |
| institution | Directory Open Access Journal |
| issn | 1471-2466 |
| language | English |
| last_indexed | 2024-03-08T16:23:55Z |
| publishDate | 2024-01-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Pulmonary Medicine |
| spelling | doaj.art-02a9b6267fda44a782cee53fcbb5f3fc2024-01-07T12:06:52ZengBMCBMC Pulmonary Medicine1471-24662024-01-0124111110.1186/s12890-023-02776-yThe impact of respiratory reactance in oscillometry on survival in patients with idiopathic pulmonary fibrosisTatsuru Ishikawa0Hirotaka Nishikiori1Yuki Mori2Keiko Fujino3Atsushi Saito4Mamoru Takahashi5Koji Kuronuma6Shiro Hinotsu7Hirofumi Chiba8Department of Respiratory Medicine and Allergology, Sapporo Medical University School of MedicineDepartment of Respiratory Medicine and Allergology, Sapporo Medical University School of MedicineDepartment of Respiratory Medicine and Allergology, Sapporo Medical University School of MedicineDepartment of Urology, Sapporo Medical University School of MedicineDepartment of Respiratory Medicine and Allergology, Sapporo Medical University School of MedicineDepartment of Respiratory Medicine and Allergology, Sapporo Medical University School of MedicineDepartment of Respiratory Medicine and Allergology, Sapporo Medical University School of MedicineDepartment of Biostatistics and Data Management, Sapporo Medical University School of MedicineDepartment of Respiratory Medicine and Allergology, Sapporo Medical University School of MedicineAbstract Background Idiopathic pulmonary fibrosis (IPF) is a progressive disease with a poor prognosis. Pulmonary function tests (PFTs) aid in evaluating the disease status of IPF. The clinical significance of oscillometry measurements in interstitial lung diseases has recently been reported. Our previous study showed that respiratory reactance (Xrs) measured by oscillometry reflected disease severity and predicted subsequent lung capacity decline in patients with IPF. However, the direct impact of Xrs on survival needs to be determined, and there are currently no reference values in oscillometry to predict prognosis. Therefore, this study aimed to investigate the association between oscillometry measurements, particularly Xrs, and survival in patients with IPF and to determine the cutoff values of Xrs that predict 3-year survival. Methods We analyzed the relationship between the measured values of PFT and oscillometry derived from 178 patients with IPF. Univariate and multivariate Cox proportional hazards analyses were performed to investigate the relationships between clinical indices at the time of the first oscillometry and survival. We performed the time-dependent receiver operating characteristic (ROC) curve analysis to set the optimized cutoff values of Xrs for 3-year survival prediction. We examined the discriminating power of cutoff values of Xrs on survival using the Kaplan–Meier method and the log-rank test. Results Xrs components, especially in the inspiratory phase (In), significantly correlated with the PFT values. In the multivariate analyses, Xrs (all of reactance at 5 Hz [X5], resonant frequency [Fres], and low-frequency reactance area [ALX] in the inspiratory phase) had a significant impact on survival (X5, p = 0.003; Fres, p = 0.016; ALX, p = 0.003) independent of age, sex, and other prognostic factors derived from the univariate analysis. The area under the ROC curve was 0.765, 0.759, and 0.766 for X5 In, Fres In, and ALX In, with cutoff values determined at − 0.98, 10.67, and 5.32, respectively. We found significant differences in survival after dividing patients using each of the cutoff values of Xrs. Conclusions In patients with IPF, Xrs measured by oscillometry significantly impacted survival. We also determined the cutoff values of Xrs to discriminate patients with poor prognoses.https://doi.org/10.1186/s12890-023-02776-yOscillometryLung physiologyInterstitial lung disease (ILD)Idiopathic pulmonary fibrosis (IPF)Respiratory reactance |
| spellingShingle | Tatsuru Ishikawa Hirotaka Nishikiori Yuki Mori Keiko Fujino Atsushi Saito Mamoru Takahashi Koji Kuronuma Shiro Hinotsu Hirofumi Chiba The impact of respiratory reactance in oscillometry on survival in patients with idiopathic pulmonary fibrosis BMC Pulmonary Medicine Oscillometry Lung physiology Interstitial lung disease (ILD) Idiopathic pulmonary fibrosis (IPF) Respiratory reactance |
| title | The impact of respiratory reactance in oscillometry on survival in patients with idiopathic pulmonary fibrosis |
| title_full | The impact of respiratory reactance in oscillometry on survival in patients with idiopathic pulmonary fibrosis |
| title_fullStr | The impact of respiratory reactance in oscillometry on survival in patients with idiopathic pulmonary fibrosis |
| title_full_unstemmed | The impact of respiratory reactance in oscillometry on survival in patients with idiopathic pulmonary fibrosis |
| title_short | The impact of respiratory reactance in oscillometry on survival in patients with idiopathic pulmonary fibrosis |
| title_sort | impact of respiratory reactance in oscillometry on survival in patients with idiopathic pulmonary fibrosis |
| topic | Oscillometry Lung physiology Interstitial lung disease (ILD) Idiopathic pulmonary fibrosis (IPF) Respiratory reactance |
| url | https://doi.org/10.1186/s12890-023-02776-y |
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