Susceptibility to SARS-CoV-2 and MERS-CoV in Beagle Dogs
The coronavirus disease 19 (COVID-19) pandemic, caused by the severe acute respiratory syndrome, coronavirus 2 (SARS-CoV-2), has resulted in unprecedented challenges to healthcare worldwide. In particular, the anthroponotic transmission of human coronaviruses has become a common concern among pet ow...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-02-01
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| Series: | Animals |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2076-2615/13/4/624 |
| _version_ | 1797622813495918592 |
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| author | Kwang-Soo Lyoo Yoon-Hwan Yeo Sung-Geun Lee Minjoo Yeom Joo-Yeon Lee Kyung-Chang Kim Daesub Song |
| author_facet | Kwang-Soo Lyoo Yoon-Hwan Yeo Sung-Geun Lee Minjoo Yeom Joo-Yeon Lee Kyung-Chang Kim Daesub Song |
| author_sort | Kwang-Soo Lyoo |
| collection | DOAJ |
| description | The coronavirus disease 19 (COVID-19) pandemic, caused by the severe acute respiratory syndrome, coronavirus 2 (SARS-CoV-2), has resulted in unprecedented challenges to healthcare worldwide. In particular, the anthroponotic transmission of human coronaviruses has become a common concern among pet owners. Here, we experimentally inoculated beagle dogs with SARS-CoV-2 or Middle East respiratory syndrome (MERS-CoV) to compare their susceptibility to and the pathogenicity of these viruses. The dogs in this study exhibited weight loss and increased body temperatures and shed the viruses in their nasal secretions, feces, and urine. Pathologic changes were observed in the lungs of the dogs inoculated with SARS-CoV-2 or MERS-CoV. Additionally, clinical characteristics of SARS-CoV-2, such as increased lactate dehydrogenase levels, were identified in the current study. |
| first_indexed | 2024-03-11T09:15:35Z |
| format | Article |
| id | doaj.art-02ab00a55fba4915bc88529d81986f27 |
| institution | Directory Open Access Journal |
| issn | 2076-2615 |
| language | English |
| last_indexed | 2024-03-11T09:15:35Z |
| publishDate | 2023-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Animals |
| spelling | doaj.art-02ab00a55fba4915bc88529d81986f272023-11-16T18:39:13ZengMDPI AGAnimals2076-26152023-02-0113462410.3390/ani13040624Susceptibility to SARS-CoV-2 and MERS-CoV in Beagle DogsKwang-Soo Lyoo0Yoon-Hwan Yeo1Sung-Geun Lee2Minjoo Yeom3Joo-Yeon Lee4Kyung-Chang Kim5Daesub Song6Korea Zoonosis Research Institute, Jeonbuk National University, Iksan 54531, Republic of KoreaKorea Zoonosis Research Institute, Jeonbuk National University, Iksan 54531, Republic of KoreaKorea Zoonosis Research Institute, Jeonbuk National University, Iksan 54531, Republic of KoreaDepartment of Veterinary Medicine Virology Laboratory, College of Veterinary Medicine and Research Institute for Veterinary Science, Seoul National University, Seoul 08826, Republic of KoreaDivision of Emerging Infectious Disease and Vector Research, Center for Infectious Diseases Research, National Institute of Health, Korea Disease Control and Prevention Agency, Cheongju 28159, Republic of KoreaDivision of Emerging Infectious Disease and Vector Research, Center for Infectious Diseases Research, National Institute of Health, Korea Disease Control and Prevention Agency, Cheongju 28159, Republic of KoreaDepartment of Veterinary Medicine Virology Laboratory, College of Veterinary Medicine and Research Institute for Veterinary Science, Seoul National University, Seoul 08826, Republic of KoreaThe coronavirus disease 19 (COVID-19) pandemic, caused by the severe acute respiratory syndrome, coronavirus 2 (SARS-CoV-2), has resulted in unprecedented challenges to healthcare worldwide. In particular, the anthroponotic transmission of human coronaviruses has become a common concern among pet owners. Here, we experimentally inoculated beagle dogs with SARS-CoV-2 or Middle East respiratory syndrome (MERS-CoV) to compare their susceptibility to and the pathogenicity of these viruses. The dogs in this study exhibited weight loss and increased body temperatures and shed the viruses in their nasal secretions, feces, and urine. Pathologic changes were observed in the lungs of the dogs inoculated with SARS-CoV-2 or MERS-CoV. Additionally, clinical characteristics of SARS-CoV-2, such as increased lactate dehydrogenase levels, were identified in the current study.https://www.mdpi.com/2076-2615/13/4/624SARS-CoV-2MERS-CoVdogsusceptibility |
| spellingShingle | Kwang-Soo Lyoo Yoon-Hwan Yeo Sung-Geun Lee Minjoo Yeom Joo-Yeon Lee Kyung-Chang Kim Daesub Song Susceptibility to SARS-CoV-2 and MERS-CoV in Beagle Dogs Animals SARS-CoV-2 MERS-CoV dog susceptibility |
| title | Susceptibility to SARS-CoV-2 and MERS-CoV in Beagle Dogs |
| title_full | Susceptibility to SARS-CoV-2 and MERS-CoV in Beagle Dogs |
| title_fullStr | Susceptibility to SARS-CoV-2 and MERS-CoV in Beagle Dogs |
| title_full_unstemmed | Susceptibility to SARS-CoV-2 and MERS-CoV in Beagle Dogs |
| title_short | Susceptibility to SARS-CoV-2 and MERS-CoV in Beagle Dogs |
| title_sort | susceptibility to sars cov 2 and mers cov in beagle dogs |
| topic | SARS-CoV-2 MERS-CoV dog susceptibility |
| url | https://www.mdpi.com/2076-2615/13/4/624 |
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