Altered regional homogeneity in pediatric bipolar disorder during manic state: a resting-state fMRI study.

UNLABELLED: Pediatric bipolar disorder (PBD) is a severely debilitating illness, which is characterized by episodes of mania and depression separated by periods of remission. Previous fMRI studies investigating PBD were mainly task-related. However, little is known about the abnormalities in PBD, es...

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Main Authors: Qian Xiao, Yuan Zhong, Dali Lu, Weijia Gao, Qing Jiao, Guangming Lu, Linyan Su
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3590243?pdf=render
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author Qian Xiao
Yuan Zhong
Dali Lu
Weijia Gao
Qing Jiao
Guangming Lu
Linyan Su
author_facet Qian Xiao
Yuan Zhong
Dali Lu
Weijia Gao
Qing Jiao
Guangming Lu
Linyan Su
author_sort Qian Xiao
collection DOAJ
description UNLABELLED: Pediatric bipolar disorder (PBD) is a severely debilitating illness, which is characterized by episodes of mania and depression separated by periods of remission. Previous fMRI studies investigating PBD were mainly task-related. However, little is known about the abnormalities in PBD, especially during resting state. Resting state brain activity measured by fMRI might help to explore neurobiological biomarkers of the disorder. METHODS: Regional homogeneity (ReHo) was examined with resting-state fMRI (RS-fMRI) on 15 patients with PBD in manic state, with 15 age-and sex-matched healthy youth subjects as controls. RESULTS: Compared with the healthy controls, the patients with PBD showed altered ReHo in the cortical and subcortical structures. The ReHo measurement of the PBD group was negatively correlated with the score of Young Mania Rating Scale (YMRS) in the superior frontal gyrus. Positive correlations between the ReHo measurement and the score of YMRS were found in the hippocampus and the anterior cingulate cortex in the PBD group. CONCLUSIONS: Altered regional brain activity is present in patients with PBD during manic state. This study presents new evidence for abnormal ventral-affective and dorsal-cognitive circuits in PBD during resting state and may add fresh insights into the pathophysiological mechanisms underlying PBD.
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spelling doaj.art-02abc5ae6069451fa3fd26c87a45a45e2022-12-21T17:24:51ZengPublic Library of Science (PLoS)PLoS ONE1932-62032013-01-0183e5797810.1371/journal.pone.0057978Altered regional homogeneity in pediatric bipolar disorder during manic state: a resting-state fMRI study.Qian XiaoYuan ZhongDali LuWeijia GaoQing JiaoGuangming LuLinyan SuUNLABELLED: Pediatric bipolar disorder (PBD) is a severely debilitating illness, which is characterized by episodes of mania and depression separated by periods of remission. Previous fMRI studies investigating PBD were mainly task-related. However, little is known about the abnormalities in PBD, especially during resting state. Resting state brain activity measured by fMRI might help to explore neurobiological biomarkers of the disorder. METHODS: Regional homogeneity (ReHo) was examined with resting-state fMRI (RS-fMRI) on 15 patients with PBD in manic state, with 15 age-and sex-matched healthy youth subjects as controls. RESULTS: Compared with the healthy controls, the patients with PBD showed altered ReHo in the cortical and subcortical structures. The ReHo measurement of the PBD group was negatively correlated with the score of Young Mania Rating Scale (YMRS) in the superior frontal gyrus. Positive correlations between the ReHo measurement and the score of YMRS were found in the hippocampus and the anterior cingulate cortex in the PBD group. CONCLUSIONS: Altered regional brain activity is present in patients with PBD during manic state. This study presents new evidence for abnormal ventral-affective and dorsal-cognitive circuits in PBD during resting state and may add fresh insights into the pathophysiological mechanisms underlying PBD.http://europepmc.org/articles/PMC3590243?pdf=render
spellingShingle Qian Xiao
Yuan Zhong
Dali Lu
Weijia Gao
Qing Jiao
Guangming Lu
Linyan Su
Altered regional homogeneity in pediatric bipolar disorder during manic state: a resting-state fMRI study.
PLoS ONE
title Altered regional homogeneity in pediatric bipolar disorder during manic state: a resting-state fMRI study.
title_full Altered regional homogeneity in pediatric bipolar disorder during manic state: a resting-state fMRI study.
title_fullStr Altered regional homogeneity in pediatric bipolar disorder during manic state: a resting-state fMRI study.
title_full_unstemmed Altered regional homogeneity in pediatric bipolar disorder during manic state: a resting-state fMRI study.
title_short Altered regional homogeneity in pediatric bipolar disorder during manic state: a resting-state fMRI study.
title_sort altered regional homogeneity in pediatric bipolar disorder during manic state a resting state fmri study
url http://europepmc.org/articles/PMC3590243?pdf=render
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