Altered regional homogeneity in pediatric bipolar disorder during manic state: a resting-state fMRI study.
UNLABELLED: Pediatric bipolar disorder (PBD) is a severely debilitating illness, which is characterized by episodes of mania and depression separated by periods of remission. Previous fMRI studies investigating PBD were mainly task-related. However, little is known about the abnormalities in PBD, es...
Main Authors: | , , , , , , |
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Format: | Article |
Language: | English |
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Public Library of Science (PLoS)
2013-01-01
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Series: | PLoS ONE |
Online Access: | http://europepmc.org/articles/PMC3590243?pdf=render |
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author | Qian Xiao Yuan Zhong Dali Lu Weijia Gao Qing Jiao Guangming Lu Linyan Su |
author_facet | Qian Xiao Yuan Zhong Dali Lu Weijia Gao Qing Jiao Guangming Lu Linyan Su |
author_sort | Qian Xiao |
collection | DOAJ |
description | UNLABELLED: Pediatric bipolar disorder (PBD) is a severely debilitating illness, which is characterized by episodes of mania and depression separated by periods of remission. Previous fMRI studies investigating PBD were mainly task-related. However, little is known about the abnormalities in PBD, especially during resting state. Resting state brain activity measured by fMRI might help to explore neurobiological biomarkers of the disorder. METHODS: Regional homogeneity (ReHo) was examined with resting-state fMRI (RS-fMRI) on 15 patients with PBD in manic state, with 15 age-and sex-matched healthy youth subjects as controls. RESULTS: Compared with the healthy controls, the patients with PBD showed altered ReHo in the cortical and subcortical structures. The ReHo measurement of the PBD group was negatively correlated with the score of Young Mania Rating Scale (YMRS) in the superior frontal gyrus. Positive correlations between the ReHo measurement and the score of YMRS were found in the hippocampus and the anterior cingulate cortex in the PBD group. CONCLUSIONS: Altered regional brain activity is present in patients with PBD during manic state. This study presents new evidence for abnormal ventral-affective and dorsal-cognitive circuits in PBD during resting state and may add fresh insights into the pathophysiological mechanisms underlying PBD. |
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institution | Directory Open Access Journal |
issn | 1932-6203 |
language | English |
last_indexed | 2024-12-24T00:12:05Z |
publishDate | 2013-01-01 |
publisher | Public Library of Science (PLoS) |
record_format | Article |
series | PLoS ONE |
spelling | doaj.art-02abc5ae6069451fa3fd26c87a45a45e2022-12-21T17:24:51ZengPublic Library of Science (PLoS)PLoS ONE1932-62032013-01-0183e5797810.1371/journal.pone.0057978Altered regional homogeneity in pediatric bipolar disorder during manic state: a resting-state fMRI study.Qian XiaoYuan ZhongDali LuWeijia GaoQing JiaoGuangming LuLinyan SuUNLABELLED: Pediatric bipolar disorder (PBD) is a severely debilitating illness, which is characterized by episodes of mania and depression separated by periods of remission. Previous fMRI studies investigating PBD were mainly task-related. However, little is known about the abnormalities in PBD, especially during resting state. Resting state brain activity measured by fMRI might help to explore neurobiological biomarkers of the disorder. METHODS: Regional homogeneity (ReHo) was examined with resting-state fMRI (RS-fMRI) on 15 patients with PBD in manic state, with 15 age-and sex-matched healthy youth subjects as controls. RESULTS: Compared with the healthy controls, the patients with PBD showed altered ReHo in the cortical and subcortical structures. The ReHo measurement of the PBD group was negatively correlated with the score of Young Mania Rating Scale (YMRS) in the superior frontal gyrus. Positive correlations between the ReHo measurement and the score of YMRS were found in the hippocampus and the anterior cingulate cortex in the PBD group. CONCLUSIONS: Altered regional brain activity is present in patients with PBD during manic state. This study presents new evidence for abnormal ventral-affective and dorsal-cognitive circuits in PBD during resting state and may add fresh insights into the pathophysiological mechanisms underlying PBD.http://europepmc.org/articles/PMC3590243?pdf=render |
spellingShingle | Qian Xiao Yuan Zhong Dali Lu Weijia Gao Qing Jiao Guangming Lu Linyan Su Altered regional homogeneity in pediatric bipolar disorder during manic state: a resting-state fMRI study. PLoS ONE |
title | Altered regional homogeneity in pediatric bipolar disorder during manic state: a resting-state fMRI study. |
title_full | Altered regional homogeneity in pediatric bipolar disorder during manic state: a resting-state fMRI study. |
title_fullStr | Altered regional homogeneity in pediatric bipolar disorder during manic state: a resting-state fMRI study. |
title_full_unstemmed | Altered regional homogeneity in pediatric bipolar disorder during manic state: a resting-state fMRI study. |
title_short | Altered regional homogeneity in pediatric bipolar disorder during manic state: a resting-state fMRI study. |
title_sort | altered regional homogeneity in pediatric bipolar disorder during manic state a resting state fmri study |
url | http://europepmc.org/articles/PMC3590243?pdf=render |
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