Cochlea cell-specific marker expression upon in vitro Hes1 knockdown

Cochlea cell-specific marker expression upon in vitro Hes1 knockdown

NOTCH pathway proteins, including the transcriptional factor HES1, play crucial roles in the development of the inner ear by means of the lateral inhibition mechanism, in which supporting cells have their phenotype preserved while they are prevented from becoming hair cells. Genetic manipulation of...

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Bibliographic Details
Main Authors: A.C. Batissoco, K. Lezirovitz, D.B. Zanatta, C.R.M.L. Hemza, L.R. Vasques, B.E. Strauss, R.C. Mingroni-Netto, L.A. Haddad, R.F. Bento, J. Oiticica
Format: Article
Language:English
Published: Associação Brasileira de Divulgação Científica 2021-05-01
Series:Brazilian Journal of Medical and Biological Research
Subjects:
shRNA
Hearing loss
Inner hair cells
Organ of Corti
Hes1 knockdown
Lentivirus
Online Access:http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2021000700601&tlng=en

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