Oral Immunotherapy in Food Allergy: A Critical Pediatric Perspective
There is evidence that in children with persistent IgE-mediated food allergy (FA) to cow's milk, hen's egg, and peanut, oral allergen-specific immunotherapy (OIT) may increase the reaction threshold to the culprit food allergen(s). OIT may protect patients from the occurrence of severe rea...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-02-01
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| Series: | Frontiers in Pediatrics |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fped.2022.842196/full |
| _version_ | 1818324442789445632 |
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| author | Aysegul Akarsu Giulia Brindisi Alessandro Fiocchi Anna Maria Zicari Stefania Arasi |
| author_facet | Aysegul Akarsu Giulia Brindisi Alessandro Fiocchi Anna Maria Zicari Stefania Arasi |
| author_sort | Aysegul Akarsu |
| collection | DOAJ |
| description | There is evidence that in children with persistent IgE-mediated food allergy (FA) to cow's milk, hen's egg, and peanut, oral allergen-specific immunotherapy (OIT) may increase the reaction threshold to the culprit food allergen(s). OIT may protect patients from the occurrence of severe reactions in case of accidental ingestion of the culprit food during treatment. Notwithstanding, many gaps are still unsolved, including safety issues, identification of predictive biomarkers, and post-desensitization efficacy. In this perspective, the use of omalizumab (Anti-IgE monoclonal antibody) has been proposed as an adjunctive treatment to OIT in order to reduce the risk of allergic reactions related to OIT. This review aims to summarize the current evidence and unmet needs on OIT in children with FA to enhance the development of longitudinal, prospective, and well-designed studies able to fill the current gaps soon. |
| first_indexed | 2024-12-13T11:28:39Z |
| format | Article |
| id | doaj.art-02aef3f73eaf43498210b1ac54b52a45 |
| institution | Directory Open Access Journal |
| issn | 2296-2360 |
| language | English |
| last_indexed | 2024-12-13T11:28:39Z |
| publishDate | 2022-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pediatrics |
| spelling | doaj.art-02aef3f73eaf43498210b1ac54b52a452022-12-21T23:48:03ZengFrontiers Media S.A.Frontiers in Pediatrics2296-23602022-02-011010.3389/fped.2022.842196842196Oral Immunotherapy in Food Allergy: A Critical Pediatric PerspectiveAysegul Akarsu0Giulia Brindisi1Alessandro Fiocchi2Anna Maria Zicari3Stefania Arasi4Division of Allergy and Asthma, Department of Pediatrics, Hacettepe University Faculty of Medicine, Ankara, TurkeyDepartment of Maternal and Child Health and Urological Sciences, Sapienza University of Rome, Rome, ItalyTranslational Research in Pediatric Specialities Area, Division of Allergy, Bambino Gesù Children's Hospital (IRCCS), Rome, ItalyDepartment of Maternal and Child Health and Urological Sciences, Sapienza University of Rome, Rome, ItalyTranslational Research in Pediatric Specialities Area, Division of Allergy, Bambino Gesù Children's Hospital (IRCCS), Rome, ItalyThere is evidence that in children with persistent IgE-mediated food allergy (FA) to cow's milk, hen's egg, and peanut, oral allergen-specific immunotherapy (OIT) may increase the reaction threshold to the culprit food allergen(s). OIT may protect patients from the occurrence of severe reactions in case of accidental ingestion of the culprit food during treatment. Notwithstanding, many gaps are still unsolved, including safety issues, identification of predictive biomarkers, and post-desensitization efficacy. In this perspective, the use of omalizumab (Anti-IgE monoclonal antibody) has been proposed as an adjunctive treatment to OIT in order to reduce the risk of allergic reactions related to OIT. This review aims to summarize the current evidence and unmet needs on OIT in children with FA to enhance the development of longitudinal, prospective, and well-designed studies able to fill the current gaps soon.https://www.frontiersin.org/articles/10.3389/fped.2022.842196/fullchildrencow's milk allergydesensitizationfood allergyegg allergyoral immunotherapy |
| spellingShingle | Aysegul Akarsu Giulia Brindisi Alessandro Fiocchi Anna Maria Zicari Stefania Arasi Oral Immunotherapy in Food Allergy: A Critical Pediatric Perspective Frontiers in Pediatrics children cow's milk allergy desensitization food allergy egg allergy oral immunotherapy |
| title | Oral Immunotherapy in Food Allergy: A Critical Pediatric Perspective |
| title_full | Oral Immunotherapy in Food Allergy: A Critical Pediatric Perspective |
| title_fullStr | Oral Immunotherapy in Food Allergy: A Critical Pediatric Perspective |
| title_full_unstemmed | Oral Immunotherapy in Food Allergy: A Critical Pediatric Perspective |
| title_short | Oral Immunotherapy in Food Allergy: A Critical Pediatric Perspective |
| title_sort | oral immunotherapy in food allergy a critical pediatric perspective |
| topic | children cow's milk allergy desensitization food allergy egg allergy oral immunotherapy |
| url | https://www.frontiersin.org/articles/10.3389/fped.2022.842196/full |
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