Engineering Botulinum Toxins to Improve and Expand Targeting and SNARE Cleavage Activity

Engineering Botulinum Toxins to Improve and Expand Targeting and SNARE Cleavage Activity

Botulinum neurotoxins (BoNTs) are highly successful protein therapeutics. Over 40 naturally occurring BoNTs have been described thus far and, of those, only 2 are commercially available for clinical use. Different members of the BoNT family present different biological properties but share a similar...

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Bibliographic Details
Main Authors: Elena Fonfria, Mark Elliott, Matthew Beard, John A. Chaddock, Johannes Krupp
Format: Article
Language:English
Published: MDPI AG 2018-07-01
Series:Toxins
Subjects:
recombinant
target secretion inhibitors
rational design
receptors
enzyme
Online Access:http://www.mdpi.com/2072-6651/10/7/278

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