Combination Therapy with Etilefrine and Pleurodesis for Refractory Congenital Chylothorax
Etilefrine, a sympathomimetic agent, is reportedly effective against postoperative chylothorax. However, its effectiveness in treating congenital chylothorax was unknown. We report herein a case of refractory congenital chylothorax treated with etilefrine in a late preterm neonate with massive fetal...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Karger Publishers
2020-09-01
|
| Series: | Biomedicine Hub |
| Subjects: | |
| Online Access: | https://www.karger.com/Article/FullText/509903 |
| _version_ | 1818505690456522752 |
|---|---|
| author | Yutaro Tomobe Uiko Mizuguchi Akihiro Shimotakahara Naoki Shimojima Kaoru Okazaki |
| author_facet | Yutaro Tomobe Uiko Mizuguchi Akihiro Shimotakahara Naoki Shimojima Kaoru Okazaki |
| author_sort | Yutaro Tomobe |
| collection | DOAJ |
| description | Etilefrine, a sympathomimetic agent, is reportedly effective against postoperative chylothorax. However, its effectiveness in treating congenital chylothorax was unknown. We report herein a case of refractory congenital chylothorax treated with etilefrine in a late preterm neonate with massive fetal chylous pleural effusion. The chylothorax was unresponsive to previous treatments, including dietary and pharmacological treatment and thoracic duct ligation. The pleural effusion decreased after intravenous etilefrine was begun on day of life (DOL) 84 and resolved after the addition of chemical pleurodesis with OK-432 on DOL 90. This combination therapy may be a viable treatment option for cases of congenital chylothorax that are unresponsive to other treatments. |
| first_indexed | 2024-12-10T21:54:18Z |
| format | Article |
| id | doaj.art-02b1d1ac319d4c44a245d89881aa3aea |
| institution | Directory Open Access Journal |
| issn | 2296-6870 |
| language | English |
| last_indexed | 2024-12-10T21:54:18Z |
| publishDate | 2020-09-01 |
| publisher | Karger Publishers |
| record_format | Article |
| series | Biomedicine Hub |
| spelling | doaj.art-02b1d1ac319d4c44a245d89881aa3aea2022-12-22T01:32:05ZengKarger PublishersBiomedicine Hub2296-68702020-09-0153667010.1159/000509903509903Combination Therapy with Etilefrine and Pleurodesis for Refractory Congenital ChylothoraxYutaro TomobeUiko MizuguchiAkihiro ShimotakaharaNaoki ShimojimaKaoru OkazakiEtilefrine, a sympathomimetic agent, is reportedly effective against postoperative chylothorax. However, its effectiveness in treating congenital chylothorax was unknown. We report herein a case of refractory congenital chylothorax treated with etilefrine in a late preterm neonate with massive fetal chylous pleural effusion. The chylothorax was unresponsive to previous treatments, including dietary and pharmacological treatment and thoracic duct ligation. The pleural effusion decreased after intravenous etilefrine was begun on day of life (DOL) 84 and resolved after the addition of chemical pleurodesis with OK-432 on DOL 90. This combination therapy may be a viable treatment option for cases of congenital chylothorax that are unresponsive to other treatments.https://www.karger.com/Article/FullText/509903congenital chylothoraxetilefrinepleurodesis |
| spellingShingle | Yutaro Tomobe Uiko Mizuguchi Akihiro Shimotakahara Naoki Shimojima Kaoru Okazaki Combination Therapy with Etilefrine and Pleurodesis for Refractory Congenital Chylothorax Biomedicine Hub congenital chylothorax etilefrine pleurodesis |
| title | Combination Therapy with Etilefrine and Pleurodesis for Refractory Congenital Chylothorax |
| title_full | Combination Therapy with Etilefrine and Pleurodesis for Refractory Congenital Chylothorax |
| title_fullStr | Combination Therapy with Etilefrine and Pleurodesis for Refractory Congenital Chylothorax |
| title_full_unstemmed | Combination Therapy with Etilefrine and Pleurodesis for Refractory Congenital Chylothorax |
| title_short | Combination Therapy with Etilefrine and Pleurodesis for Refractory Congenital Chylothorax |
| title_sort | combination therapy with etilefrine and pleurodesis for refractory congenital chylothorax |
| topic | congenital chylothorax etilefrine pleurodesis |
| url | https://www.karger.com/Article/FullText/509903 |
| work_keys_str_mv | AT yutarotomobe combinationtherapywithetilefrineandpleurodesisforrefractorycongenitalchylothorax AT uikomizuguchi combinationtherapywithetilefrineandpleurodesisforrefractorycongenitalchylothorax AT akihiroshimotakahara combinationtherapywithetilefrineandpleurodesisforrefractorycongenitalchylothorax AT naokishimojima combinationtherapywithetilefrineandpleurodesisforrefractorycongenitalchylothorax AT kaoruokazaki combinationtherapywithetilefrineandpleurodesisforrefractorycongenitalchylothorax |