Non-Monotonic Survival of Staphylococcus aureus with Respect to Ciprofloxacin Concentration Arises from Prophage-Dependent Killing of Persisters

Non-Monotonic Survival of Staphylococcus aureus with Respect to Ciprofloxacin Concentration Arises from Prophage-Dependent Killing of Persisters

Staphylococcus aureus is a notorious pathogen with a propensity to cause chronic, non-healing wounds. Bacterial persisters have been implicated in the recalcitrance of S. aureus infections, and this motivated us to examine the persistence of S. aureus to ciprofloxacin, a quinolone antibiotic. Upon t...

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Bibliographic Details
Main Authors: Elizabeth L. Sandvik, Christopher H. Fazen, Theresa C. Henry, Wendy W.K. Mok, Mark P. Brynildsen
Format: Article
Language:English
Published: MDPI AG 2015-11-01
Series:Pharmaceuticals
Subjects:
fluoroquinolone
persistence
prophage induction
S. aureus
Online Access:http://www.mdpi.com/1424-8247/8/4/778

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