Adenovirus Vector-Derived VA-RNA-Mediated Innate Immune Responses

Adenovirus Vector-Derived VA-RNA-Mediated Innate Immune Responses

The major limitation of the clinical use of replication-incompetent adenovirus (Ad) vectors is the interference by innate immune responses, including induction of inflammatory cytokines and interferons (IFN), following in vivo application of Ad vectors. Ad vector-induced production of inflammatory c...

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Bibliographic Details
Main Authors: Hiroyuki Mizuguchi, Kenji Kawabata, Fuminori Sakurai, Kazufumi Katayama, Mitsuhiro Machitani, Kahori Shimizu, Tomoko Yamaguchi
Format: Article
Language:English
Published: MDPI AG 2011-07-01
Series:Pharmaceutics
Subjects:
adenovirus vector
VA-RNA
gene therapy
innate immunity
Online Access:http://www.mdpi.com/1999-4923/3/3/338/

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