Monitoring flux in signalling pathways through measurements of 4EBP1-mediated eIF4F complex assembly
Abstract Background The most commonly occurring cancer mutations, including oncogenes such as MYC, Ras and PIK3C, are found in signal transductions pathways feeding into the translational machinery. A broad range of translation initiation factors are also commonly found to be either amplified or mis...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
BMC
2019-05-01
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| Series: | BMC Biology |
| Online Access: | http://link.springer.com/article/10.1186/s12915-019-0658-0 |