Determination of isoniazid acetylation patterns in tuberculosis patients receiving DOT therapy under the Revised National tuberculosis Control Program (RNTCP) in India
Isoniazid is the most commonly used drug for treatment of tuberculosis, and is administered individually or in combination with other drugs as standard first line therapy. Offsetting its efficacy, severe adverse effects, especially peripheral neuropathy and hepatotoxicity, are associated with isonia...
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| Language: | English |
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Elsevier
2020-06-01
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| Series: | Saudi Pharmaceutical Journal |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S1319016420300815 |
| _version_ | 1818029703663976448 |
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| author | Faisal Imam Manju Sharma Khalid Umer Khayyam Mohammad Rashid Khan Mohammad Daud Ali Wajhul Qamar |
| author_facet | Faisal Imam Manju Sharma Khalid Umer Khayyam Mohammad Rashid Khan Mohammad Daud Ali Wajhul Qamar |
| author_sort | Faisal Imam |
| collection | DOAJ |
| description | Isoniazid is the most commonly used drug for treatment of tuberculosis, and is administered individually or in combination with other drugs as standard first line therapy. Offsetting its efficacy, severe adverse effects, especially peripheral neuropathy and hepatotoxicity, are associated with isoniazid therapy, limiting its use in tuberculosis. Isoniazid is acetylated in vivo producing hydrazine and acetyl hydrazine, which are responsible for hepatotoxicity. Marked pharmacogenetic differences in acetylation have been reported among different population across the globe. This study evaluates isoniazid acetylation patterns in tuberculosis patients receiving DOT therapy under the Revised National Tuberculosis Control Program (RNTCP) in a specialized tuberculosis hospital in north India. Of 351 patients from whom samples were taken for biochemical analysis of adverse events, 36 were assessed for acetylation patterns. Blood samples were taken 1 h after administration of a 600 mg dose of isoniazid, and plasma concentrations of isoniazid were determined using a validated HPLC method. Of these 36 patients, 20 (55.56%) were slow acetylators and 16 (44.44%) were fast acetylators. Our results are consistent with those of an earlier study conducted in a different region of India. Most biochemical changes produced during long-term isoniazid therapy resolve after therapy is terminated. |
| first_indexed | 2024-12-10T05:23:54Z |
| format | Article |
| id | doaj.art-02b741256b134c1c8e2a7f0ff48f0124 |
| institution | Directory Open Access Journal |
| issn | 1319-0164 |
| language | English |
| last_indexed | 2024-12-10T05:23:54Z |
| publishDate | 2020-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Saudi Pharmaceutical Journal |
| spelling | doaj.art-02b741256b134c1c8e2a7f0ff48f01242022-12-22T02:00:44ZengElsevierSaudi Pharmaceutical Journal1319-01642020-06-01286641647Determination of isoniazid acetylation patterns in tuberculosis patients receiving DOT therapy under the Revised National tuberculosis Control Program (RNTCP) in IndiaFaisal Imam0Manju Sharma1Khalid Umer Khayyam2Mohammad Rashid Khan3Mohammad Daud Ali4Wajhul Qamar5Department of Pharmacology and Toxicology, College of Pharmacy, King Saud University, P.O. Box: 2457, Riyadh 11451, Saudi Arabia; Corresponding author.Department of Pharmacology, School of Pharmaceutical Education and Research, Hamdard University, New Delhi 110062, IndiaDepartment of Epidemiology & Public Health, National Institute of Tuberculosis & Respiratory Diseases, New Delhi 110030, IndiaDepartment of Pharmacology and Toxicology, College of Pharmacy, King Saud University, P.O. Box: 2457, Riyadh 11451, Saudi ArabiaMohammed Al-Mana College for Medical Sciences, Abdulrazaq Bin Hammam Street, As Safa, Dammam 34222, Saudi ArabiaDepartment of Pharmacology and Toxicology, College of Pharmacy, King Saud University, Central Laboratory Research Center, P.O. Box 2457, Riyadh 11451, Saudi ArabiaIsoniazid is the most commonly used drug for treatment of tuberculosis, and is administered individually or in combination with other drugs as standard first line therapy. Offsetting its efficacy, severe adverse effects, especially peripheral neuropathy and hepatotoxicity, are associated with isoniazid therapy, limiting its use in tuberculosis. Isoniazid is acetylated in vivo producing hydrazine and acetyl hydrazine, which are responsible for hepatotoxicity. Marked pharmacogenetic differences in acetylation have been reported among different population across the globe. This study evaluates isoniazid acetylation patterns in tuberculosis patients receiving DOT therapy under the Revised National Tuberculosis Control Program (RNTCP) in a specialized tuberculosis hospital in north India. Of 351 patients from whom samples were taken for biochemical analysis of adverse events, 36 were assessed for acetylation patterns. Blood samples were taken 1 h after administration of a 600 mg dose of isoniazid, and plasma concentrations of isoniazid were determined using a validated HPLC method. Of these 36 patients, 20 (55.56%) were slow acetylators and 16 (44.44%) were fast acetylators. Our results are consistent with those of an earlier study conducted in a different region of India. Most biochemical changes produced during long-term isoniazid therapy resolve after therapy is terminated.http://www.sciencedirect.com/science/article/pii/S1319016420300815TuberculosisRNTCPDOTSIsoniazidAcetylation pattern |
| spellingShingle | Faisal Imam Manju Sharma Khalid Umer Khayyam Mohammad Rashid Khan Mohammad Daud Ali Wajhul Qamar Determination of isoniazid acetylation patterns in tuberculosis patients receiving DOT therapy under the Revised National tuberculosis Control Program (RNTCP) in India Saudi Pharmaceutical Journal Tuberculosis RNTCP DOTS Isoniazid Acetylation pattern |
| title | Determination of isoniazid acetylation patterns in tuberculosis patients receiving DOT therapy under the Revised National tuberculosis Control Program (RNTCP) in India |
| title_full | Determination of isoniazid acetylation patterns in tuberculosis patients receiving DOT therapy under the Revised National tuberculosis Control Program (RNTCP) in India |
| title_fullStr | Determination of isoniazid acetylation patterns in tuberculosis patients receiving DOT therapy under the Revised National tuberculosis Control Program (RNTCP) in India |
| title_full_unstemmed | Determination of isoniazid acetylation patterns in tuberculosis patients receiving DOT therapy under the Revised National tuberculosis Control Program (RNTCP) in India |
| title_short | Determination of isoniazid acetylation patterns in tuberculosis patients receiving DOT therapy under the Revised National tuberculosis Control Program (RNTCP) in India |
| title_sort | determination of isoniazid acetylation patterns in tuberculosis patients receiving dot therapy under the revised national tuberculosis control program rntcp in india |
| topic | Tuberculosis RNTCP DOTS Isoniazid Acetylation pattern |
| url | http://www.sciencedirect.com/science/article/pii/S1319016420300815 |
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