CARBOHYDRATE MALABSORPTION SYNDROME IN CHILDREN WITH VIRAL GASTROENTERITIS
Background: Enteric viruses (mainly rotaviruses) are the most common cause of infectious diarrhea in infants. One of the pathophysiologic mechanisms in rotaviral gastroenteritis is the reduction of the surface activity of enterocyte disaccharidases and osmotic diarrhea. Aim: To determine the...
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| Format: | Article |
| Language: | Russian |
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MONIKI
2016-02-01
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| Series: | Alʹmanah Kliničeskoj Mediciny |
| Subjects: | |
| Online Access: | https://www.almclinmed.ru/jour/article/view/39 |
| _version_ | 1831753998683602944 |
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| author | E. R. Meskina |
| author_facet | E. R. Meskina |
| author_sort | E. R. Meskina |
| collection | DOAJ |
| description | Background: Enteric viruses (mainly rotaviruses) are the most common cause of infectious diarrhea in infants. One of the pathophysiologic mechanisms in rotaviral gastroenteritis is the reduction of the surface activity of enterocyte disaccharidases and osmotic diarrhea. Aim: To determine the clinical significance of metabolic activity of intestinal microbiota in the formation of the osmotic component of viral diarrhea in children of various ages. Materials and methods: The study involved 139 children aged from 1 month to 14 years admitted to the hospital in the first 24 to 72 hours of moderate-degree viral gastroenteritis. Rotaviral infection was the most prevalent (90%). Viral etiology was confirmed by the reaction of indirect hemagglutination and multiplex real-time PCR (in feces). Total carbohydrate content in the feces was measured and fecal microflora was investigated by two methods: bacteriological and gas liquid chromatography with the determination of short-chain fatty acids. Results: The mean carbohydrate content in the feces of children below 1.5 years of age was higher than that in older children (p = 0.014). There was an inverse correlation between the concentration of rotaviral antigens and carbohydrate contents (r = -0,43, p < 0.05) and the production of acetic and propionic acids (R = -0,35, p < 0.01). The carbohydrate content in acute stage of the disease was linearly associated with time to normalization of the stool (r = +0,47, p < 0.01). Previous acute respiratory or intestinal infections within 2 months (odds ratio [OR], 14.10; 95% confidence interval [CI] 3.86–51.53), previous hospitalizations (OR = 14.17; 95% CI 2.74–74.32) and past history of intestinal dysfunction (OR 5.68; 95% CI 1.67–19.76) were predictive of severe carbohydrate malabsorption in children below 1.5 years of age. Conclusion: The lack of microbiota functional activity (assessed by production of short-chain fatty acids) determines the development of osmotic phenotype of diarrhea, that marks the total carbohydrate contents in the feces. Its predisposing factors should be taken into account when making a decision to hospitalize. |
| first_indexed | 2024-12-21T23:30:25Z |
| format | Article |
| id | doaj.art-02b7f2b3dff6479983dd55cb41d83141 |
| institution | Directory Open Access Journal |
| issn | 2072-0505 2587-9294 |
| language | Russian |
| last_indexed | 2024-12-21T23:30:25Z |
| publishDate | 2016-02-01 |
| publisher | MONIKI |
| record_format | Article |
| series | Alʹmanah Kliničeskoj Mediciny |
| spelling | doaj.art-02b7f2b3dff6479983dd55cb41d831412022-12-21T18:46:30ZrusMONIKIAlʹmanah Kliničeskoj Mediciny2072-05052587-92942016-02-01042798610.18786/2072-0505-2015-42-79-8639CARBOHYDRATE MALABSORPTION SYNDROME IN CHILDREN WITH VIRAL GASTROENTERITISE. R. Meskina0Moscow Regional Research and Clinical InstituteBackground: Enteric viruses (mainly rotaviruses) are the most common cause of infectious diarrhea in infants. One of the pathophysiologic mechanisms in rotaviral gastroenteritis is the reduction of the surface activity of enterocyte disaccharidases and osmotic diarrhea. Aim: To determine the clinical significance of metabolic activity of intestinal microbiota in the formation of the osmotic component of viral diarrhea in children of various ages. Materials and methods: The study involved 139 children aged from 1 month to 14 years admitted to the hospital in the first 24 to 72 hours of moderate-degree viral gastroenteritis. Rotaviral infection was the most prevalent (90%). Viral etiology was confirmed by the reaction of indirect hemagglutination and multiplex real-time PCR (in feces). Total carbohydrate content in the feces was measured and fecal microflora was investigated by two methods: bacteriological and gas liquid chromatography with the determination of short-chain fatty acids. Results: The mean carbohydrate content in the feces of children below 1.5 years of age was higher than that in older children (p = 0.014). There was an inverse correlation between the concentration of rotaviral antigens and carbohydrate contents (r = -0,43, p < 0.05) and the production of acetic and propionic acids (R = -0,35, p < 0.01). The carbohydrate content in acute stage of the disease was linearly associated with time to normalization of the stool (r = +0,47, p < 0.01). Previous acute respiratory or intestinal infections within 2 months (odds ratio [OR], 14.10; 95% confidence interval [CI] 3.86–51.53), previous hospitalizations (OR = 14.17; 95% CI 2.74–74.32) and past history of intestinal dysfunction (OR 5.68; 95% CI 1.67–19.76) were predictive of severe carbohydrate malabsorption in children below 1.5 years of age. Conclusion: The lack of microbiota functional activity (assessed by production of short-chain fatty acids) determines the development of osmotic phenotype of diarrhea, that marks the total carbohydrate contents in the feces. Its predisposing factors should be taken into account when making a decision to hospitalize.https://www.almclinmed.ru/jour/article/view/39childrenviral gastroenteritisсarbohydrate malabsorptionmicrobiotashort chain fatty acids |
| spellingShingle | E. R. Meskina CARBOHYDRATE MALABSORPTION SYNDROME IN CHILDREN WITH VIRAL GASTROENTERITIS Alʹmanah Kliničeskoj Mediciny children viral gastroenteritis сarbohydrate malabsorption microbiota short chain fatty acids |
| title | CARBOHYDRATE MALABSORPTION SYNDROME IN CHILDREN WITH VIRAL GASTROENTERITIS |
| title_full | CARBOHYDRATE MALABSORPTION SYNDROME IN CHILDREN WITH VIRAL GASTROENTERITIS |
| title_fullStr | CARBOHYDRATE MALABSORPTION SYNDROME IN CHILDREN WITH VIRAL GASTROENTERITIS |
| title_full_unstemmed | CARBOHYDRATE MALABSORPTION SYNDROME IN CHILDREN WITH VIRAL GASTROENTERITIS |
| title_short | CARBOHYDRATE MALABSORPTION SYNDROME IN CHILDREN WITH VIRAL GASTROENTERITIS |
| title_sort | carbohydrate malabsorption syndrome in children with viral gastroenteritis |
| topic | children viral gastroenteritis сarbohydrate malabsorption microbiota short chain fatty acids |
| url | https://www.almclinmed.ru/jour/article/view/39 |
| work_keys_str_mv | AT ermeskina carbohydratemalabsorptionsyndromeinchildrenwithviralgastroenteritis |