Spontaneous mutational patterns and novel mutations for bedaquiline and clofazimine resistance in Mycobacterium tuberculosis

Spontaneous mutational patterns and novel mutations for bedaquiline and clofazimine resistance in Mycobacterium tuberculosis

ABSTRACT The 2022 World Health Organization guidelines recommend use of two core anti-tuberculosis (TB) drugs, bedaquiline (BDQ) and clofazimine (CFZ), for treatment of drug-resistant (DR)-TB. However, several mutated Mycobacterium tuberculosis (MTB) genes, conferring BDQ and CFZ resistance, have be...

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Bibliographic Details
Main Authors: Jin Shi, Yuanyuan Liu, Tuoya Wu, Lu Li, Shujing Han, Xiao Peng, Yuanyuan Shang, Yongli Guo, Yu Pang, Mengqiu Gao, Jie Lu
Format: Article
Language:English
Published: American Society for Microbiology 2023-10-01
Series:Microbiology Spectrum
Subjects:
Mycobacterium tuberculosis
bedaquiline
clofazimine
resistance
Online Access:https://journals.asm.org/doi/10.1128/spectrum.00090-23

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